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Molnár-Institute hosting unified chromatographic modelling webinar

news-releasesMolnár-Institute for applied chromatography
June 29th 2018

Berlin, Germany: – The Molnár-Institute for Applied Chromatography is staging a webcast on using a single chromatographic modelling tool to manage analytical methods across all stages of the development life cycle.

The hour-long webinar, which will take place at 9am EDT | 2pm BST | 3pm CEST on July 12, 2018, will be hosted by Laura Bush, Editorial Director of LCGC and will feature presentations from Dr. Imre Molnár, President of Molnar-Institute for Applied Chromatography and Dr. Hans-Jürgen Rieger, Vice President of Product Management at Molnar-Institute.

Registration for the webinar is free of charge and the event will be available afterwards as a download from LCGC.

HPLC retention modeling

“In this webcast, we will present how HPLC retention modelling for reversed-phase, normal-phase, HIC, HILIC, and ion-exchange separations, can save time and resources across all stages of the life cycle of an analytical method,” explained Dr. Imre Molnár.

“Based on examples from industry, we will demonstrate how method run time can easily be reduced 10-fold with improved selectivity when redesigning an old method, while the development time needed is reduced by factor of 12 at the same time,’ said Dr. Molnár.

“We will also show how an existing USP method that frequently fails in routine runs can be understood and improved in accordance with the allowed changes (USP 621) using our DryLab®4 modelling software,” he added.

Key Learning Objectives:

The webinar will aim to deliver six key learning objectives:

  • How to reduce method run time and speed up method development time across HPLC types (reversed-phase, normal-phase, HIC, HILIC, and ion-exchange)
  • How to optimize performance of an existing method in three simple steps
  • How to use chromatographic parameters to maximize resolution
  • How to evaluate method robustness
  • How to perform an early-stage (stage 1) robustness evaluation for robust method design
  • How to use chromatographic modelling to safeguard method transfers from later out-of-specification (OoS) results

The event is aimed at scientifically oriented method developers working in qualitative and quantitative analyses using reversed-phase, normal-phase, HIC, HILIC, and ion-exchange across industries, as well as at professionals in preclinical research, clinical trials & studies, regulatory affairs, quality assurance, and impurity testing.

Live demonstrations of software-based retention modelling will include illustrations of redesigning an old method to shorten run time and improve selectivity, as well as improving an existing USP method in accordance with allowed changes (USP 621).

About Molnar-Institute

Molnár-Institute for applied chromatography focuses on new strategies for improving the efficiency and success of modern high-performance liquid chromatography (HPLC) through its method development software DryLab®4, HPLC and software training courses, and HPLC consulting.

Since its foundation in 1981, by Dr. Imre Molnár in Berlin, Molnár-Institute has followed a consistent mission, to form a center of excellence to save, reduce and optimize method development and run time in HPLC.

The institute supports ongoing research and development at universities and corporations worldwide with a team of chromatography specialists devoted to improving global health care and to ensuring the development of safe and effective products in the pharmaceutical, life-science, and food industries.

By applying its proprietary method development software DryLab®4 in conjunction with rigorous methodologies, the institute is able to optimize method development and reduce method run time in HPLC and UHPLC. Using real data from a minimal number of experimental runs, DryLab®4 builds multi-dimensional selectivity maps depicting the interaction of the most important parameters influencing an HPLC separation. This systematic, guided method development process can halve development time; help users optimize parameters based on their specific method goals, and enable easier compliance with regulatory standards (QbD).

Dr. Imre Molnár is the president of the Molnar-Institute, which is a privately owned organisation, headquartered in central Berlin.

About Dr. Imre Molnár

Dr. Molnár is founder and president of Molnár-Institute for Applied Chromatography. Receiving a doctorate degree from German Saarland University in analytical chemistry, Dr. Molnár joined Csaba Horváth’s research team at Yale, resulting in numerous publications such as the ‘Theory of Solvophobic Interactions’ and on the fundamentals of reversed phase chromatography. After returning to Europe he founded the Institute for Applied Chromatography in Berlin in 1981. Since 1984, collaborating with Dr. Lloyd Snyder and John Dolan, he has focused on in-silico method development in HPLC, resulting in the software DryLab®4, which has become a world standard for (U)HPLC method development, demonstrated by more than 200 peer-reviewed published on its scientific and industrial application.

About Dr. Hans-Jürgen Rieger

Vice President for Product Management at Molnar-Institute for Applied Chromatography, Dr. Hans-Jürgen Rieger holds a doctorate degree in Physical Chemistry from Free University of Berlin and is specialized in HPLC modelling. Having spent two years as a post doc in Freiburg, he joined Molnár-Institute in 1999 and since has gained extensive theoretical and practical knowledge in the techniques of HPLC. As a vice president he oversees DryLab®4’s technical development. Together with Dr. Molnár, he has developed new software modules for improved peak matching, multiple parameter optimization (3D resolution maps), robustness testing, and GMP-compliant method reporting. Dr. Rieger teaches DryLab®4 courses on an international scale.

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