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ZELLX® Caffeic Acid compounds
ZELLX® has become a leading supplier of Caffeic Acid and related compounds that are experiencing significant increases in market demand for their anti-inflammatory, antioxidant, antibacterial and other properties.
Caffeic acid or 3, 4-dihydroxy-cinnamic acid is an organic compound, naturally found in plants. As its name suggest, it is found in coffee and also enters the human diet through fruits, vegetables, and various herbs, including oregano and thyme. Caffeic Acid shows strong antioxidant effects and can claim antiviral, anti-inflammatory, and anticarcinogenic benefits. such as. Athletes consume the product to boost their performance.
Caffeic Acid derivatives (CADs) such as Caffeic Acid Phenyl Ester (CAPE), or Phenylethyl caffeate are finding new markets as dietary supplements, with indicated anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory pharmacological benefits.
ZELLX® Caffeic Acid products
ZELLX® products include Caffeic acid (CA), Caffeic acid phenethyl ester, and Chlorogenic acid. All products are distinguished by very high quality and HPLC grade purity (≥98%), along with highly competitive pricing and long shelf lives, enhancing their usefulness in industry, pharmaceuticals and research.
Caffeic acid (CA) is an organic phenolic compound synthesized by all plant species found in substances such as coffee, wine, tea, propolis, etc. This organic compound and its derivatives show antioxidant, anti-inflammatory and anticarcinogenic activities. The anticarcinogenic activity of CA is mediated by suppressing the generation of reactive oxygen species (ROS), decreasing the angiogenesis in cancerous tissues, blocking STAT3 (Signal Transducer and Activator of Transcription 3) signalling and suppression of MMP2 and MMP-9 (collagen IV metalloproteases) activities in tumors.
Caffeic Acid Phenethyl Ester (CAPE)
CAPE is the ester of caffeic acid and phenethyl alcohol. It is a bioactive component of honeybee hive propolis extract, which has anti-inflammatory, antitumor, antiviral, antibacterial, antifungal and immunostimulatory activities. CAPE inhibits the activation of nuclear transcription factor NF-κB and suppresses p70S6K and Akt-driven signalling pathways. Moreover, through activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha, it inhibits PDGF-induced proliferation of vascular smooth muscle cells.
Chlorogenic acid (CGA)
CGA, the conjugate acid of chlorogenate, is the ester of trans-caffeic acid and (-)-quinic acid. CGA is produced by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is the predominant class of phenolic acids found in coffee and coffee beans, known as an intermediate metabolite in the biosynthesis of lignin. CGA exhibits many biological properties including antibacterial, antioxidant, and anticarcinogenic activities. Most importantly, CGA exerts an important role as an antidiabetic agent through regulation of the whole body and tissue-specific glucose metabolism.