VTU Technology revealing protein expression advances at PepTalk San Diego

Grambach, Austria: Protein expression specialist VTU Technology will use the 2017 PepTalk Protein Science Week conference in San Diego, California to reveal significant advances in enhancing the expression of biotherapeutic proteins in microbial systems, using their Pichia pastoris platform.

VTU´s Principal R&D Manager for Process Development & Analytics, Dr. Iskandar Dib, will be presenting during the stream on Optimizing Protein Expression in Microbial Systems during the morning of Day Four of the conference.

VTU’s Chief Operating Officer, Roland Weis, will also attend the PepTalk event.

Pichia protein expression

Dr. Dib’s address, titled ‘Unleash the Yeast – Enhancing Expression of Biotherapeutics in Pichia’, shows how VTU has used a library of AOX promoter variants to express therapeutic protein candidates in Pichia pastoris at unprecedented yields often exceeding 10 g/L by finding the ideal promoter variant for each target protein.

He will demonstrate how the technology can further be used to enable cells to provide expression enhancing factors that are well-dosed and delivered just in time during expression of a target protein, thus maximizing both yield and quality.

Unprecedented yields

“This latest research underlines how our Pichia pastoris production system provides one of the most powerful and versatile recombinant protein expression and production technology platforms holding productivity records for Pichia-derived recombinant proteins,” commented VTU Technology Head of Business Development, Dr. Thomas Purkarthofer.

“Since its foundation 2008, VTU has been continuously optimizing and expanding its Pichia technology platform to generate an unparalleled spectrum of expression tools and ingenious expression strategies to meet highly specific expression needs and hence leading to more flexibility in protein production. With exclusive tools, VTU can now address multiple aspects of protein expression, providing myriad ways to reach customer goals,” added Dr. Purkarthofer.

About VTU Technology

VTU Technology, a leading contract research and development company, offers the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein expression / production enabling highest productivities delivering up to 25 g/L of secreted protein (record productivities of 35 g/L) within a few weeks development time.

VTU´s yield-enhancing Pichia pastoris expression platform is based on its proprietary AOX1 promoter libraries and set of expression enhancing helper factors, several platform strains with different genetic backgrounds, elaborated cloning and transformation protocols, a high-throughput screening and cultivation regime combined with excellent know-how in fermentation and downstream process development for maximization of product yield and overall process performance.

Headquartered in Grambach, near Graz, Austria, VTU Technology is a private company and a subsidiary of VTU Holding, an Austrian enterprise that combines several technology and engineering companies in chemistry, pharma and life science as well as in the energy industries.

More information at: www.vtu-technology.com and www.vtu.com

About PepTalk 2017

The annual Protein Science Week, PepTalk, is one of the world’s foremost forums for protein science researchers. Now In its 16th year, PepTalk attracts nearly 1,300 experts from academia, biotech and pharma organizations in more than 40 countries. A co-located exhibition features more than 100 companies.

PepTalk 2017 is a five-day event, opening January 9 at the Hilton Bayfront Hotel in San Diego, CA.

This event will cover a wide spectrum, from upstream protein R&D science to downstream biologics. The conference programs feature keynote presentations, case studies and new unpublished data from thought leaders in academia and industry. PepTalk also features three-hour short courses focusing on topics such as Production Challenges for ADCs and Fusion Proteins, Biologics Formulation Development and NextGen Sequencing of Antibody Libraries:

PepTalk 2016 will also feature extended Training Seminars and Student Fellowships providing young researchers an opportunity to present their latest work.

The event is organized by Cambridge Healthtech Institute with more information at: http://www.chi-peptalk.com