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    VALIDOGEN to present new technology benefits at Pichia 2021

    news-releasesVALIDOGEN GmbH
    March 22nd 2021

    Raaba-Grambach, Austria: Senior research scientists from protein expression specialist VALIDOGEN will present new insights at the upcoming online conference: PICHIA 2021 opening Wednesday, March 24.

    VALIDOGEN will be showing the powerful advantages of its UNLOCK PICHIA integrated recombinant protein expression toolbox that provides numerous expression tools and strategies for enhanced protein production yields and quality, with options for methanol-free protein production as well as applying glycoengineering tools for the efficient production of tailor-made glycoproteins.

    Pichia 2021 virtual conference

    VALIDOGEN is a sponsor of the Pichia 2021 conference that will be hosted online over seven days from March 24, 2021, focusing on recombinant protein expression with the yeast Pichia pastoris (Komagataella phaffii) and will make direct contributions to the agenda.

    On Day 4 of the conference, (March 29, 6.20 p.m. CEST, 09.20 a.m. PDT), Dr. Aid Atlic, VALIDOGEN Senior Scientist for Process Development, will deliver a presentation on ‘High cell density cultivations of Pichia pastoris in microbioreactor system’, showing how incorporating a microfermentation system into VALIDOGEN’s strain development program can combine the advantages of microscale cultivations (large number of clones in one batch) with those of bioreactor cultivations (continuous feeding, high cell density and tightly controlled conditions).

    Dr. Atlic will show how multi-gram-per-litre protein titers can be obtained with productivities that are predictive for bioreactor cultivations, thereby further leveraging the benefits of the UNLOCK PICHIA toolbox, using examples and case studies to illustrate applications of Pichia high cell density microscale cultivations in strain development and process optimization projects.

    End-to-end development project

    On Day 6, (March 31, 6.40 p.m. CEST, 09.40 a.m. PDT), VALIDOGEN’s Principal Scientist for Process Development and Analytics, Dr. Iskandar Dib, will present methods for ‘Fast track development with Pichia pastoris – meeting the challenges of protein production using UNLOCK PICHIA’. This presentation will follow an end-to-end project for an albumin fusion NBE candidate that illustrates the scope of VALIDOGEN’s services, technologies and capabilities within a typical development program.

    Starting with initial clone screening and subsequent strain improvement using the UNLOCK PICHIA toolbox, the project team then performed upstream and downstream process set-up to generate a first purified sample for functionality testing. In a second phase, an improved and fully scalable production process was developed and characterized.

    BIO Europe Spring online – March 22-25

    VALIDOGEN has a long-standing relationship with the BIO – Europe series of networking events and will use its return to the BIO Europe Spring to identify new partnering opportunities and offer innovative development pathways with UNLOCK PICHIA for research and manufacturing companies.

    It will use BIO Europe’s proven partneringONE® networking platform to conduct multiple virtual face to face meetings over the four days of the event.

    About VALIDOGEN GmbH

    VALIDOGEN GmbH (formerly VTU Technology), a leading contract research and development company, offers UNLOCK PICHIA – the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein expression and production.

    VALIDOGEN develops high performance expression strains and economically viable protein production processes for the manufacture of biopharmaceuticals, enzymes and various other recombinant proteins and provides tailor-made solutions for customers from different industry sectors – such as pharma, diagnostics, food & feed, chemical, agro and other industries.

    Headquartered in Raaba-Grambach, near Graz, Austria, VALIDOGEN is a private company and independent subsidiary of the KonValue Holding GmbH.

    More information: www.validogen.com and www.unlockpichia.com

    About PICHIA 2021

    Research Corporation Technologies (RCT) has been sponsoring and hosting Pichia conferences to support the Pichia pastoris yeast recombinant protein expression community since 2006. Recent conferences have been staged alternately in Europe and the USA but the 2021 event, organized in partnership with BioGrammatics, will be hosted online as a virtual conference, with presentations and discussions live streamed and available to watch on demand.

    The conference is a seven day event opening March 24. Sessions will be live streamed from 4 p.m. to 8 p.m. CEST, 7 a.m. to 11 a.m. PDT each day.

    Further information at: https://www.eventinterface.com/pichia-2021/

    Resources

    Click on UNLOCK PICHIA for further information on Pichia pastoris production toolbox.

    VALIDOGEN to present new technology benefits at Pichia 2021

    VALIDOGEN’s UNLOCK PICHIA toolbox provides a wide range of protein expression technologies that can be used in different combinations to provide very precisely tailored and optimised processes.

    VALIDOGEN to present new technology benefits at Pichia 2021

    Dr. Aid Atlic, VALIDOGEN Senior Scientist for Process Development, will talk on ‘High cell density cultivations of Pichia pastoris in microbioreactor system’.

    VALIDOGEN to present new technology benefits at Pichia 2021

    Dr. Iskandar Dib, VALIDOGEN Principal Scientist for Process Development and Analytics, will present methods for fast-track protein production strain and process development using UNLOCK PICHIA tools.

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