VALIDOGEN presenting industrial protein production tools at ESIB 2019

news-releasesVALIDOGEN GmbH
November 13th 2019

Raaba – Grambach, Austria: Protein expression specialist VALIDOGEN will be a high profile presence as sponsor at the fourth European Summit of Industrial Biotechnology (ESIB) in Graz, Austria next week (18 – 21 November).

VALIDOGEN will use the conference to communicate its advanced capabilities in industrial protein production strain & process development.


Centerpiece of VALIDOGEN’s technology is its UNLOCK PICHIA protein production toolbox comprising of a diverse set of molecular tools and expression strategies for efficient recombinant protein production in Pichia pastoris. The toolbox opens up multiple strategies for generating high-performance strains and production processes meeting industry requirements.

VALIDOGEN provides industrial protein production solutions ideally suited for efficient large scale manufacturing processes with low cost-of-goods. VALIDOGEN’s Pichia expression system not only enables cultivation with high volumetric productivities but also simplifies downstream processing due to efficient product secretion and low levels of endogenous proteins in the culture supernatant.

“All components of our Pichia toolbox are thoroughly characterized and full documentation is readily available to support regulatory filings for different applications of protein products including strains for the manufacture of GRAS products and strains free of antibiotic selection markers”, commented VALIDOGEN Head of Business Development, Dr. Thomas Purkarthofer. “In addition, all reagents used in the course of strain development are certified animal-origin-free and our unique 2nd generation promoter library enables safe and convenient methanol-free protein production processes without compromising process economy”, said Dr. Purkarthofer.

Enzyme Engineering

Supporting companies in product innovation, VALIDOGEN´s established high-throughput microscale strain cultivation and screening protocols can also facilitate screening and identification of improved enzyme variants. “The key advantage of using UNLOCK PICHIA for the generation of enzyme variants is that engineering is performed in the final production host without a change of the host system from primary screen to final enzyme production. In addition, application of UNLOCK PICHIA ensures production of high-value enzymes at lower manufacturing costs”, Dr. Purkarthofer noted.


VALIDOGEN GmbH (formerly VTU Technology), a leading contract research and development company, offers the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein expression and production.

VALIDOGEN´s yield-enhancing UNLOCK PICHIA expression platform is based on its proprietary AOX1 promoter libraries and set of expression enhancing helper factors, several platform strains with different genetic backgrounds, elaborated cloning and transformation protocols, a high-throughput screening and cultivation regime combined with excellent know-how in fermentation and downstream process development for maximization of product yield and overall process performance. The platform enables highest productivities delivering up to 25 g/L of secreted protein (record productivities of 35 g/L) within a few weeks development time.

VALIDOGEN develops high performance expression strains and economically viable protein production processes for the manufacture of biopharmaceuticals, enzymes and various other recombinant proteins and provides tailor- made solutions for customers from different industry sectors – such as pharma, diagnostics, food & feed, chemical, agro and other industries.

VALIDOGEN is a private company and independent subsidiary of the KonValue Group. and

About ESIB 2019

The European Summit of Industrial Biotechnology (ESIB) was founded in 2016 to provide a new European communication platform for industrial biotechnology, bringing together scientific topics with industrial needs and priorities, economic demands, funding resources and political aspirations in an event that combines knowledge-sharing, networking and recreation.

The fourth summit, ESIB 2019, is a three-day event opening November 18 at the Messecongress in the center of the ancient Austrian university city of Graz.

The event is organized by the Austrian Centre of Industrial Biotechnology (ACIB) with more information available at: