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VALIDOGEN presenting UNLOCK PICHIA tools at RAFT® 13 in Florida

news-releasesVALIDOGEN GmbH
October 9th 2019

Raaba – Grambach, Austria: Protein expression specialist VALIDOGEN will be a prominent contributor to the RAFT fermentation technology conference in Florida, USA, this month.

VALIDOGEN will use the highly regarded bi-annual conference to communicate the advantages of its yield-enhancing ‘UNLOCK PICHIA’ protein production toolbox to enable fine-tuning of protein expression by its diversity of molecular tools and expression strategies for Pichia pastoris.

Harness Pichia for your application

VALIDOGEN’s Head of Operations, Dr. Roland Weis, will contribute to the ‘Cell Factory Design & Engineering’ session on Day One of the conference (Sunday, October 27, 2019 2:00 PM – 4:30 PM) with his presentation: ‘UNLOCK PICHIA – a toolbox to maximize productivity through diversity’.

Dr. Weis will show how ‘UNLOCK PICHIA’ provides an ideal response to an industrial protein production environment in which novel product classes and current trends in protein production demand more versatile and yet robust expression systems.

Dr. Weis will tell the conference that continuous expansion and improvement of the UNLOCK PICHIA technology platform facilitates targeted debottlenecking of protein expression all the way from transcription and translation to translocation, protein folding and secretion thereby enabling the expression of more complex proteins without compromising product quality. The broad diversity of molecular tools available in VALIDOGEN’s toolbox provides solutions for different requirements in order to best meet the aims of each specific application.

Maximising yield

“Selection of best-performing clones from strain engineering approaches in microscale, i.e. 96-deep-well plates, is directly followed by cultivation in benchtop bioreactors to reconfirm screening results and at the same time gather information on growth and production behavior,” Dr. Weis says.

“Subsequent bioreactor cultivation process optimization elucidating the interplay of important process parameters such as pH-value, temperature, feeding profile as well as biomass level results in maximization of yield & quality of the target protein,” he adds.


VALIDOGEN GmbH (previously VTU Technology GmbH) is a leading contract research and development company, offering the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein expression and production.

Based on its technology platform known as UNLOCK PICHIA, VALIDOGEN develops high performance expression strains and economically viable protein production processes for the manufacture of biopharmaceuticals, enzymes and various other recombinant proteins and provides tailor – made solutions for customers from different industry sectors – such as pharma, diagnostics, food & feed, chemical, agro and other industries.

Headquartered in Grambach, near Graz, Austria, VALIDOGEN is a private company and independent subsidiary of the KonValue Group.

More Information: and

About RAFT 2019

The biannual Recent Advances in Fermentation Technology (RAFT®) conference provides a forum for industrial and academic scientists to discuss the latest developments in fermentation as applied in research and industry.

The conference is one of a series of specialist meetings sponsored by America’s Society for Industrial Microbiology and Biotechnology. The first RAFT conference was held in San Diego in 1995 and held every two years since.

The 2019 RAFT conference (RAFT® 13) is a four day event opening October 27 at the Hyatt Regency Coconut Point hotel at Ft. Myers, Florida.

The conference will feature an exhibition, exhibitor showcases and a full program of presentations including keynote presentations on Cell Factory Design & Engineering, Big Data AI & Machine Learning, Scale-up & Tech Transfer and Continuous Manufacturing.

The event is organized by the US-based Society for Industrial Microbiology and Biotechnology (SIMB) with more information at:


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