The MOLNÁR-INSTITUTE to present Leveraged Modeling Insights to Separation Science Symposium

Berlin: Advanced computer modelling specialist the MOLNÁR-INSTITUTE for Applied Chromatography will present new insights into multidimensional chromatographic separation analysis at the upcoming Separation Science Virtual Symposium.

The free to register two-day online event, ‘Separation Science – The State of the Art in Life Science Analysis,’ is jointly organized by the Chromatographic Society’s CHROMAcademy and LCGC International.

Targeted at separation scientists specializing in pharmaceutical and biopharmaceutical analysis, the December 2025 symposium will feature a panel of leading practitioners discussing the latest advances and technologies for both small-molecule and large-molecule analysis.

3-D approach to HPLC challenges

The MOLNÁR-INSTITUTE is a leading sponsor of the event. Its scientific contribution will be presented by Senior Researcher & Application Specialist Arnold Zöldhegyi, in a talk titled Employing Multidimensional Design Space Modeling Across Frequent Chromatographic Challenges—Use Cases from Recently Published Results.

His presentation will open the Day Two Afternoon Session (Wednesday, December 3, 11:45–12:05 hrs EST).

The presentation will add further depth and personal observation to a recently published and similarly titled LCGC International study that demonstrates the benefits and applications of advanced computer-assisted modeling in modern chromatography (see Resources).

Robust and transferable methods

Arnold Zöldhegyi will show how the development of robust and transferable methods in HPLC can be hampered by poor initial design or insufficient control of critical method attributes.

Modeling tools such as the MOLNÁR-INSTITUTE’s DryLab®4, built on chromatographic first principles, enable creation of multidimensional design spaces from a minimal set of input experiments. These digital models—serving as system-specific chromatographic fingerprints—allow in silico evaluation of parameters, assessment of system transferability, and early identification of potential performance risks.

The presentation will include several case-study examples addressing challenges such as column replacement, buffer compatibility, and batch-to-batch variability, offering practical strategies for maintaining consistent analytical performance.

‌About Molnár-Institute

Founded in 1981, The MOLNÁR-INSTITUTE develops DryLab®4, a software for UHPLC modelling for a world-wide market. Its powerful modules gradient editor, peak tracking, automation, robustness and Design Space Comparison allow for the most sophisticated method development as required across modern pharma industries. Analytical scientists use DryLab®4 to understand chromatographic interactions, to reduce analysis time, to increase robustness, and to conform to Analytical Quality by Design (AQbD) principles, according to the recently published ICH Q14 regulatory framework.

The MOLNÁR-INSTITUTE is a registered partner of the US-FDA, CDC and many other regulatory bodies. DryLab®4 pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.

Further information at: http://www.molnar-institute.com/

About Separation Science Virtual Symposium

Founded in 1983, LCGC International covers all key developments in separation science through its monthly journal, website, newsletters, webcasts, and educational content. It has partnered with the Chromatographic Society (ChromSoc) to organize the virtual symposium “Separation Science — The State of the Art in Life Science Analysis.”

The two-day event hosted online December 3–4, 2025, will feature ten expert presentations and live Q&A sessions, moderated by LCGC Executive Editor Alasdair Matheson. Sessions open daily at 09:15 hrs EST, offering insights into the latest innovations in small- and large-molecule separation for pharmaceutical and biopharmaceutical applications.

Resources

Click on Leveraging Multidimensional Modeling to Resolve Frequent Separation Challenges in HPLC to access the original published study.
Click on The State of The Art in Life Science Analysis for further information on LCGC/ChromSoc Virtual Symposium and registration.