Multidimensional design space modelling insights at Balaton Symposium

Berlin: – The MOLNÁR-INSTITUTE for Applied Chromatography will once again have a prominent presence at the upcoming Balaton Symposium on High-Performance Separation Methods in Hungary, participating as a sponsor, exhibitor and scientific contributor.

The Institute is a Bronze Sponsor of the meeting and will contribute an address from senior scientist Arnold Zöldhegyi sharing use cases on ‘Employing Multidimensional Design Space Modeling across Frequent Chromatographic Challenges’.

In his oral presentation, he will show how computer modelling tools, such as the MOLNÁR-INSTITUTE’s DryLab®4 analytical platform, aligned with Analytical Quality by Design (AQbD) principles, can prove highly effective in proactively eliminating potential issues and reactive troubleshooting in HPLC analysis.

Overcoming separation challenges

He will reference several peer-reviewed examples to present sound and systematic modeling strategies that address specific challenges in dynamic separations. These include identifying suitable replacement columns and workable operating conditions, comparing various column chemistries and competitive stationary phases; evaluating batch-to-batch inconsistencies, mitigating HPLC system-to-system differences; and managing transferability challenges arising from differences between volatile and non-volatile buffer systems within identical pH-settings.

These case studies clearly demonstrate that, alongside appropriate instrument and stationary phase selection, a detailed, multidimensional understanding of the interactions among method parameters—and their consistent fine-tuning—is essential for achieving and maintaining consistent analytical method performance.

About The MOLNAR-INSTITUTE

Founded in 1981, The MOLNÁR-INSTITUTE develops DryLab®4, a software for UHPLC modelling for a world-wide market. Its powerful modules gradient editor, peak tracking, automation, robustness and Design Space Comparison allow for the most sophisticated method development as required across modern pharma industries. Analytical scientists use DryLab®4 to understand chromatographic interactions, to reduce analysis time, to increase robustness, and to conform to Analytical Quality by Design (AQbD) principles, according to the recently published ICH Q14 regulatory framework.

The MOLNÁR-INSTITUTE is a registered partner of the US-FDA, CDC and many other regulatory bodies. DryLab®4 pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.

Further information at: http://www.molnar-institute.com/

About Balaton Symposium 2025

Founded in 1995, the Balaton Symposia on High-Performance Separation has become a leading event for separation sciences.

Organized by the Hungarian Society for Separation Sciences (HSSS), the conference is now staged biennially to bring together international separation scientists and associates to the latest and most important advances in different areas of separations sciences, including GC, UHPLC, HPLC, SFC, HPCE, MS and variations, with numerous applications to small molecule, pharmaceuticals, biopharmaceuticals, and other research fields.

The 14th Balaton Symposium is a three-day event opening September 7, returning to the Hotel Azúr in Siófok, Hungary.

The scientific program covers all aspects of separation sciences in liquid, gas, and supercritical fluid phases as well as hyphenation with advanced detection technologies, including fundamental chromatographic separations and detection principles, methodological and technological advances including separation materials, column technologies and instruments. The 2025 symposium will place special emphasis on new developments in pharmaceutical, environmental, biomedical, forensic, life sciences and industrial separation methods.

The event is organized by HSSS, with further information at: https://2025.balatonsymposium.hu

Resources

Click on Molnár-Institute Method Development Services for other information.