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    MOLNÁR-INSTITUTE to share Covid-19 related research at HPLC 2022 San Diego

    news-releasesMolnár-Institute for applied chromatography
    May 19th 2022

    Berlin: – The Molnár-Institute for Applied Chromatography will again be a high-profile presenter at the 2022 International Symposium on High Performance Liquid Phase Separations (HPLC 22), held in San Diego, California.

    The Molnár-Institute stand in booth 320 at the Town & Country Hotel and Conference Center, in San Diego, will present the organization’s leading-edge training courses and revolutionary DryLab®4 separation modelling software that improves the efficiency and success of modern high-performance liquid chromatography (HPLC) through method development.

    Characterizing COVID-19 therapies

    Attending as invited speakers, Molnár-Institute will also contribute to the scientific agenda presenting a highlighted topic on ‘Expediting the characterization of COVID-19 therapeutic mAbs using innovative ultra-short column formats and automated chromatography-based method modeling’.

    Senior scientist Arnold Zöldhegyi will demonstrate results of continuous scientific collaboration between Molnar-Institute, University of Geneva, along with the Waters Corporation – showing new development milestones in various modes of ultrahigh-performance liquid chromatography ((U)HPLC) that has been extensively used in modern biopharmaceutical analysis, including monoclonal antibody purity and identity control.

    Rapid drug development

    These play a particularly valuable role in rapid development of unorthodox life-saving drugs to counter the Covid-19 pandemic, such as IgG-type monoclonal antibody (mAb) immunoglobulins like tocilizumab, casirivimab and imdevimab, that can be used to manage hospitalized patients’ successful recovery. The challenge with these drugs has been to overcome the high heterogenicity and poor stability that can drastically affect their efficacy and safety.

    The presentation will highlight the benefits of using innovative, state-of-the-art, ultra-short (1-2 cm) RP-, HILIC- and IEX column formats along with a model-facilitated and automated method development approach, applied on intact and the subunit level analysis of mAb cocktails. This synergetic combination of instrument hardware and modeling software can deliver practical advantages in speeding-up method turnaround at significantly enhanced performance by automating experiments, modeling and model-comparing complete separation systems (e.g., different elution modes in IEX) and effortlessly performing virtual method transfer (scale-up/down) for any column formats and chromatographic systems.

    The end result has been to reduce time required for development and verification of three or four complementary analytical methods to only 1-2 days of experimental work, with each chromatographic analysis requiring just one or two minutes and whole characterization of a mAb cocktail product analyzed by three or four chromatographic methods feasible within one hour, instead of several days.

    About Molnár-Institute

    Founded in 1981, Molnár-Institute develops DryLab®4, a software for UHPLC modelling for a world-wide market. Its powerful modules allow for the most sophisticated method development as required across pharma industries. Analytical scientists use DryLab®4 to understand chromatographic interactions, reduce analysis times, increase method robustness, and conform to Analytical Quality by Design (AQbD) principles.

    The Molnár-Institute is a registered partner to the US-FDA, CDC and many other regulatory bodies. DryLab®4 has pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.

    Further information at:

    About HPLC 2022

    The International Symposium on High Performance Liquid Phase Separations (HPLC) is an international scientific forum focusing on high-performance liquid chromatography in its various forms, along with complementary separation techniques such as electrophoresis, electrochromatography, field-flow fractionation, supercritical fluid chromatography and hyphenated techniques, such as LC/MS, CE/MS and SFC/MS. The conference also considers microfluidic, nanofluidic and chip separations, diagnostic systems, and other leading technologies.

    Founded in 1973, the annual symposium alternates between venues in Europe and the USA, with the 2022 conference to be held in San Diego, CA, as a six-day event opening June 18 at the Town and Country Hotel and Conference Center. The event is returning for the first time since 2019, having suffered three ‘lost years’ due to the COVID pandemic.

    The event is organized by Barr Enterprises , with more information at:


    Click on Molnár-Institute Method Development Services for other information.


    Analytical Method Development: Workflow, Advantages and Future developments

    MOLNÁR-INSTITUTE to share Covid-19 related research at HPLC 2022 San Diego

    Molnár-Institute at HPLC 2022 San Diego.

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