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    Waters Corporation latest video blog (VLOG) features MOLNÁR-INSTITUTE DryLab® 3D modeling in method lifecycle management

    news-releasesMolnár-Institute for applied chromatography
    November 30th 2021

    Berlin: – The latest video blog (VLOG) from the US-based Waters Corporation features Molnár-Institute for Applied Chromatography’s DryLab®4 method development software, used in combination with Waters Empower CDS platform to determine Method Operable Design Regions (MODRs).

    The video is the latest in Waters’ Get Empowered video series featuring Empower CDS as an important tool to implement method lifecycle management (MLCM).

    Determining MODRs

    The new episode (Episode #14 /Tip #239) focuses on the topic Determine Your Method’s Operable Design Regions (MODRS) with Empower CDS and DryLab®4 (Molnár-Institute). It is presented by Neil Lander, Principal Product Manager in Waters’ Informatics group, who provides internal support for Empower CDS Software and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives.

    Lander, a highly experience analytical chemist, shows how Empower CDS and DryLab®4 can be seamlessly combined in an automated solution for generating and comparing multi-dimensional Design Spaces derived from individual column chemistries.

    Enhanced method transfer

    Having the ability to determine and achieve robust method performance, especially with different stationary phases, provides maximum flexibility and increase success, when it comes to method transfer.

    Orthogonal peak tracking with UV and MS data

    These chromatographic-based Design Spaces allow users to visualize sets of conditions, that lead to baseline separation and perform orthogonal peak tracking with UV data and MS data, generated by the ACQUITY QDa and SQD2 modules.

    Use of 3D design spaces also allow determination of working conditions based on critical method attributes (CMAs) and robust critical method parameter (CMP) ranges for maximum flexibility and ease of method transfer.

    Designing purposeful experiments to observe multivariable effects is essential to developing robust methods.  With the seamless automation between Empower and DryLab®4’s ability to incorporate chromatographic principles in its experimental design models, researchers can quickly and easily determine how separation method changes as variables are changed.


    Founded in 1981, Molnár-Institute develops DryLab®4, a software for UHPLC modeling for a world-wide market. Its powerful modules allow for the most sophisticated method development as required across pharma industries. Analytical scientists use DryLab® to understand chromatographic interactions, reduce runtimes, increase robustness, and conform to Analytical Quality by Design (AQbD) standards.

    The Molnár-Institute is a registered vendor to the US FDA, CDC and many other regulatory bodies. DryLab® has pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.

    Further information at: http://www.molná

    About Waters Corporation

    Waters Corporation is a publicly traded Analytical Laboratory instrument and software company headquartered in Milford, Massachusetts, that has become the world’s leading specialty measurement company focused on improving human health and well-being through the application of high-value analytical technologies and industry leading scientific expertise.

    Waters markets to laboratory-dependent organizations in the market areas of liquid chromatography, mass spectrometry, supercritical fluid chromatography, laboratory informatics, rheometry and microcalorimetry.

    Over more than six decades, Waters has continually pioneered chromatography, mass spectrometry and thermal analysis innovations in pharmaceutical discovery, assuring food and water safety and ensuring the integrity of chemical entities.

    With a global workforce of more than 7,400 employees, Waters operates in 35 countries, including 14 manufacturing facilities and with products available in more than 100 countries

    Visit to find out more.


    Click on DryLab software for chromatographic retention modeling for further information.
    Click on Waters Tips 246: Method Operable Design to watch the video.
    Click on Waters Empower Chromatography Data System for further information.
    Click on Molnár-Institute for Applied Chromatography’s DryLab®4 for further information.


    Analytical Method Development: Workflow, Advantages and Future developments

    Waters Corporation latest video blog (VLOG) features MOLNÁR-INSTITUTE DryLab® 3D modeling in method lifecycle management

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