Presenting design space modelling at EAS as solution to robustness and method transfer challenges

Berlin: – The MOLNÁR-INSTITUTE for Applied Chromatography is heading back to the Eastern Analytical Symposium (EAS) in Plainsboro, New Jersey this November as both an exhibitor and scientific contributor.

Senior Scientist Arnold Zöldhegyi, alongside the Molnár-Institute team will return to the podium to present on DryLab® software, highlighting how 3D design space modeling resolves critical method transfer and robustness challenges in liquid chromatography.

Scientific Program: Using Modeling Fingerprints to Tackle Transferability Issues

Zöldhegyi’s presentation, “Addressing Method Transfer and Robustness Challenges Using Design Space Modeling,” is scheduled for the Symposium’s Technical Oral Program session, Quality by Design: Building Robust and Transferable LC Methods, chaired by Lasangi Dhanapala of Alexion Pharmaceuticals (Monday, November 16, 09:20 – 09:40).

The talk will examine why robustness and ruggedness failures in industrial practice – especially during intra- and inter-laboratory method transfers – frequently stem from incomplete method understanding and uncharacterized HPLC system-related effects. Crucial factors include dwell volume discrepancies, extra-column band broadening, and subtle variations in solvent delivery, mixing dynamics, and column thermal management.

Zöldhegyi will demonstrate how in silico modeling aligned with Analytical Quality by Design (AQbD) principles supports proactive method development and reactive troubleshooting. Using DryLab® software, researchers can generate digitized modeling “fingerprints” of diverse chromatographic instruments to conduct thorough in silico transferability studies and evaluate platform-dependent robustness parameters.

Exhibition Stand: Explore DryLab®4 at Booth L3

As in previous years, DryLab®4 will be showcased in depth at the Molnár Institute for Applied Chromatography booth (Booth L3) at the Crowne Plaza Princeton Conference Center. Attendees can explore the latest advancements in this leading-edge software for HPLC and UHPLC modeling.

Interactive demonstrations will highlight how DryLab’s integrated modules enable sophisticated method development – providing deeper insight into complex chromatographic interactions, shortening runtimes, and rigorously evaluating robustness in full alignment with Analytical Quality by Design (AQbD) principles.

About Molnár-Institute

Founded in 1981, Molnár-Institute develops DryLab®4, a software for UHPLC modelling for a world-wide market. Its powerful modules gradient editor, peak tracking, automation, robustness and Design Space Comparison allow for the most sophisticated method development as required across modern pharma industries.

Analytical scientists use DryLab®4 to understand chromatographic interactions, to reduce analysis time, to increase robustness, and to conform to AQbD-principles, according to the recently published ICH Q14 regulatory framework.

The Molnár-Institute is a registered partner to the US-FDA, CDC and many other regulatory bodies. DryLab®4 has pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.

Further information at: http://www.molnar-institute.com/

About EAS 2026

The Eastern Analytical Symposium and Exposition (EAS) provides an annual forum that provides professional scientists and students working in the Eastern USA with continuing education in the analytical and allied sciences through the presentation of symposia of papers, workshops, and short courses.

Over 65 years, EAS has provided cutting-edge information for the analyst with research presentations on practical and novel technologies. The symposium now typically contains more than 450 papers on a wide variety of subjects, from pharmaceutical analysis to art conservation, emphasizing practical applications of a wide range of technologies including Liquid chromatography, Raman spectroscopy, microscopy, and sensors in solving real-life problems,

Themed Navigate the Future of Analytical Chemistry: Intelligence and Integrity, the 65^th Anniversary EAS Symposium will again be a three-day event, opening November 16 at the Crowne Plaza Princeton Conference Center in Plainsboro, NJ. The 2026 Symposium will again include technical sessions, short courses, special lectures, workshops and student seminars, as well as a co-located exhibition of analytical science apparatus and supplies.

The event is organized by EAS with further information available at:  https://eas.org

Resources

Click on DryLab® – Software for Analytical Design Space Modeling for further information.