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MOLNÁR-INSTITUTE to show impact of computer separation modelling on HPLC at Euroanalysis Geneva
Berlin: – The Molnár-Institute for Applied Chromatography will be contributing to the scientific program at the forthcoming Euroanalysis conference in Geneva, scheduled for late August 2023.
The Institute’s President, Dr. Imre Molnár, will demonstrate how Analytical Design Space modeling solutions, such as the Institute’s DryLab Modeling Platform, have been instrumental in enhancing the speed, precision, and adaptability necessary for efficient and robust pharmaceutical analysis.
Rationalizing HPLC method development
The Molnár-Institute will also showcase its range of Design Space modeling software modules at Booth 3 at Geneva’s International Conference Center. By utilizing DryLab, the entire high-performance liquid chromatography (HPLC) method development process is streamlined. This allows for data contextualization and informed, science-based decision-making, improving analytical outcomes and creating error-proof methods that save time and resources.
Imre Molnár’s presentation, titled “Recent Developments in HPLC Modeling”, will offer a historical overview of the software’s evolution since the mid-80s. He will discuss the initial focus on isocratic separations, the subsequent extension to gradient methods in Reversed Phase Chromatography (RPC), and Ion-Exchange Chromatography (IEC), and recent advancements including HILIC, HIC, SFC, and the modeling and assessment of an analytical procedure’s robustness.
Setting up and managing the in-silico laboratory
Dr. Molnár wills show how ever more sophisticated techniques increasingly need in-silico experimental IT-support to measure peak positioning, depending on pH, temperature, gradient time, salt- or additive concentration, etc. From the measured data, a software application like DryLab®4 can reduce the time needed to model a separation across a wide range of variable conditions from many hours to a few seconds.
Dr. Molnár will also demonstrate how software applications like DryLab can significantly reduce the time needed to model a separation across various conditions. He will also illustrate the reliability and reproducibility of results achieved using 2D and 3D modeling of chromatographic separations, enabling quicker drug development and faster market-entry of new, more efficient drugs. His presentation will include several case studies from recent industry developments.
Founded in 1981, Molnár-Institute develops DryLab®4, a software for UHPLC modelling for a world-wide market. Its powerful modules gradient editor, peak tracking, automation, robustness and Design Space Comparison allow for the most sophisticated method development as required across modern pharma industries. Analytical scientists use DryLab®4 to understand chromatographic interactions, to reduce analysis time, to increase robustness, and to conform to Analytical Quality by Design (AQbD) principles, according to the recently published ICH Q14 regulatory framework.
The Molnár-Institute is a registered partner of the US-FDA, CDC and many other regulatory bodies. DryLab®4 pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.
Further information at: http://www.molnar-institute.com/
About Euroanalysis 2023
The Organizing Committee welcomes you to Geneva on August 27th to 31st, 2023 for Euroanalysis is a biannual international conference. This 21st edition is jointly organized by the Division of Analytical Sciences of the Swiss Chemical Society (DAS) and the University of Geneva.
The Euroanalysis series of international conferences organized by the Division of Analytical Chemistry of the European Chemical Society provides a biannual forum for discussion of the latest developments in analytical sciences.
The 2023 Euroanalysis Geneva conference, Euroanalysis XXI, will be a five-day event, opening August 27 at the Geneva International Conference Centre (CICG).
The theme of the 2023 meeting will be ‘Analytical Probing of Complex Systems’ to reflect the urgent need to observe chemical changes in complex systems, from materials surfaces, to living cells and ecosystems, in real time and with adequate spatial resolution.
Four parallel sessions for keynote and contributed oral presentations are planned, along with daily poster sessions.
The event is organized by the European Chemical society in partnership with Symporg SA, with further information at: https://www.euroanalysis2023.ch/index.html
Click on Molnár-Institute Method Development Services for other information.