Molnár-Institute to exhibit latest DryLab® capabilities at PittCon USA

Berlin: – The Molnár-Institute for Applied Chromatography will exhibit at the upcoming PittCon USA conference in Philadelphia, showing its latest DryLab^® capabilities in modelling liquid chromatographic separations.

The Molnár-Institute stand at booth 3201 at the Pennsylvania Convention Center will display applications of the DryLab^® software running processes in high performance and ultra-high performance liquid chromatography (HPLC and UHPLC).

Molnár-Institute will also present details of its method development services, HPLC and software training courses, and HPLC consulting services.

DryLab^®4 separation modeling

DryLab®, first developed in the mid-1980s by founder and president Imre Molnár with Lloyd Snyder, John Dolan and Tom Jupille at California-based LC Resources Inc. is now widely used in both the pharmaceutical industry and the life science community.

Based on just 12 chromatographic input runs, the software models the complex interactions in liquid chromatographic separations, integrating theoretical solvophobic interactions and linear solvent strength (LSS) to predict the movement of peaks, selectivity changes and retention times within a multidimensional design space. This allows one-click optimization for any separation, considering myriad possible set points of the design space and computing all tG-pH/tC/aC and other variations.

New systematic design capabilities

The software’s automation module can create method sets in the most efficient order, execute runs and acquire results from the respective Chromatographic Data System (CDS). Mass and other integrated data is retrieved to minimize ambiguity in peak tracking. Automated zoom algorithm presents clear-cut chromatograms while a peak alignment option allows peak movement to be identified across varying method conditions.

Recent advances in the modeling engine now allows for systematic designs with extra calculable parameters such as flow rate, gradient start- and gradient end-%B, providing extra dimensions to Critical Resolution Maps (CRMs). Based on these and other innovations, the software’s visual method modeling provides deeper insights and scientific understanding of the chromatography behind the chosen method.

Enhanced Risk Management

Further instrument parameters have been added to DryLab’s Robustness module , allowing for an even better assessment of a methods pitfalls in routine use. Understanding these at the earliest possible stage both enhances risk management and allows redemption of methods that would turn out to be less-than-optimal at later stages in the analytical life cycle.

The Knowledge Management Documentation reporting tool now features a set of project information windows allowing operator to define and lay down statements as templates for all areas of Analytical Quality by Design (AQbD) and derived workflow, allowing for knowledge-transfer to related projects.

About Molnar-Institute

Molnár-Institute for applied chromatography focuses on new strategies for improving the efficiency and success of modern high-performance liquid chromatography (HPLC) through its method development software DryLab^®4, HPLC, software training courses, and HPLC consulting.

Since its foundation in 1981, by Dr. Imre Molnár in Berlin, Molnár-Institute has followed a consistent mission, to form a center of excellence to save, reduce and optimize method development and run time in HPLC.

The institute supports ongoing research and development at universities and corporations worldwide with a team of chromatography specialists devoted to improving global health care and to ensuring the development of safe and effective products in the pharmaceutical, life-science, chemical and food industries.

By applying its proprietary method development software DryLab^®4 in conjunction with rigorous methodologies, the institute is able to optimize method development and reduce method run time in HPLC and UHPLC. Using real data from a small number of experimental runs, DryLab^® builds multi-dimensional selectivity maps depicting the interaction of the most important parameters influencing an HPLC separation. This systematic, guided method development process can halve development time, help users optimize parameters based on their specific method goals, and enable easier compliance with regulatory standards (QbD).

Dr. Imre Molnár remains president of the Molnar-Institute, which is a privately-owned organisation, headquartered in central Berlin.

About Pittcon 2019

Pittcon has become one of North America’s largest annual conferences and expositions on laboratory science. Since its origins as The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Pittcon has evolved into an event that now encompasses life sciences, pharmaceutical discovery and QA, food safety, environmental, bioterrorism and other emerging markets.

Pittcon 2019 is a five-day event opening March 17 at the Pennsylvania Convention Center in Philadelphia, PA. It is expected to attract more than 16,000 attendees from industry, academia and government from over 90 countries worldwide.

More information at: http://pittcon.org