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    Molnár-Institute teams with Waters to showcase new Empower 3 and DryLab®4 Automation features at EAS 2020

    news-releasesMolnár-Institute for applied chromatography
    November 5th 2020

    Berlin: – Molnár-Institute for Applied Chromatography will be a prominent presence at the upcoming Eastern Analytical Symposium (EAS) virtual conference, contributing insights on Design Space Comparison and showcasing its multivariate DryLab® Modeling Tools that yield robust analytical method designs.

    Molnár-Institute will contribute a lecture and a poster to the scientific program. The poster is presenting an automated modeling workflow for Design Space Comparison. The on-demand oral lecture with the topic “Automated Development of a Design Space using Modeling Software for Complex Drug Products according to QbD-Expectations” will be available for watching during the four-day online event, opening November 16th 2020 until December 31st.

    Automated model verification

    In partnership with the Massachusetts-based Waters Corporation, Molnár-Institute’s virtual trade booth at the online symposium will present the state-of-the art connectivity offered by the DryLab®4 and Empower® software packages. This new module introduces an automation capability that works on three levels of the DryLab®4-AQbD-process.

    This new level of automation creates, performs and retrieves input runs, automates model verification and robustness verification. Generated method sets are run in the most economic and ecological order, taking into account subsequent equilibration steps.  DryLab®4 then accesses the Empower data-stream for additional peak-information on peak-shapes, such as tailing factors, different peak-widths and peak-names, which can directly be used for model-adjustment.

    Design Space Comparison

    The virtual booth will also contain details of Molnár’s own software development, the Design Space Comparison Module (DSCM), that provides a systematic approach to find alternative (replacement) columns. It allows instant comparisons between Design Spaces obtained on different stationary phases to identify the Common Space, where all sample components are separated with sufficient selectivity and resolution.

    The DSCM also maps retention behavior of actual compounds of interest, rather than common test solutes, in an entire 3D-Design Space, instead of few selected conditions (as suggested by earlier column tests).

    Method development and training 

    The Molnár-Institute booth at EAS 2020 will also present additional services such as renowned Method development services (see Resources) and DryLab®4 WebEx Training. The 3 seasons (each 2 hours) provide guidance for HPLC and UHPLC method development using DryLab®4 tools. It is suitable for DryLab users and the participants are guided through a comprehensive method development process, starting with basic one-dimensional model calculations and continuing through multi-dimensional (3D) model optimizations. Users learn to develop, adjust, and improve methods, focusing on decreasing run times while maintaining the desired selectivity.

    They also recognize the trend to embrace Analytical Quality by Design (AQbD) principles including modern method-lifecycle aspects such as long-term usability and performance characteristics of the methods.

    About Molnár-Institute

    Founded in 1981, Molnár-Institute develops DryLab®4, a software for UHPLC modeling for a world-wide market. Its powerful modules allow for the most sophisticated method development as required across pharma industries. Analytical scientists use DryLab® to understand chromatographic interactions, reduce runtimes, increase robustness, and conform to Analytical Quality by Design (AQbD) standards.

    The Molnár-Institute is a registered vendor to the US FDA, CDC and many other regulatory bodies. DryLab® has pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science- and risk driven perspective on HPLC Quality Control and -Assurance.

    Further information at:  DryLab®. Right First Time. Every Time.

    About EAS 2020

    The Eastern Analytical Symposium and Exposition (EAS) is held each year to provide professional scientists and students working in the Eastern USA with continuing education in the analytical and allied sciences through the presentation of symposia of papers, workshops, and short courses.

    For more than 50 years, the EAS Technical Program has provided cutting-edge information for the analyst with research presentations on practical and novel technologies. The symposium now typically contains over 450 papers on a wide variety of subjects, from pharmaceutical analysis to art conservation, emphasizing practical applications of a wide range technologies including High Performance Liquid Chromatography (HPLC), Raman spectroscopy, microscopy, and sensors in solving real-life problems.

    An exposition of apparatus and supplies allied to these sciences is held concurrently with the symposia.

    Because of the COVID-19 pandemic, EAS 2020 will be a four-day online event, opening November 16 2020.

    The event is organised by EAS in partnership with eShow with further information available at: EAS 2020


    Click on Molnár-Institute Method Development Services for further information.


    Analytical Method Development: Workflow, Advantages and Future developments


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