MOLNÁR-INSTITUTE exhibiting at EAS 2021 and DDRS 2021 on-site events in November

Berlin: – Molnár-Institute for Applied Chromatography (Molnár) will present advanced insights on chromatographic characterization of therapeutic proteins at the upcoming Eastern Analytical Symposium (EAS), returning as a physical conference to Plainsboro, New Jersey, USA.

At the same time, Molnár-Institute  will attend the prestigious science focused International Conference on Advances in Pharmaceutical Drug Development, Quality Control and Regulatory Sciences (DDRS 2021) in Budapest, Hungary, which will examining key aspects of drug development, quality control, regulatory challenges, and the practical use and handling of complex drug products for a broad range of dosage forms.

EAS exhibitor and presenter

Molnár-Institute will also be an exhibitor at EAS, showcasing its DryLab® 4 software modelling and analytical platform from Booth L3 at the Crowne Plaza Princeton Conference Center. The Molnár team in New Jersey will include Marketing and Account Manager Magdalena Marinski, Business Strategy director Markus Molnár and DryLab® Product Manager Dr. Hans-Jürgen Rieger.

Dr. Szabolcs Fekete from Waters corporation will contribute a 30-minute online lecture on ‘Software-assisted chromatographic method development for characterization of therapeutic proteins’ to the session on Biopharmaceuticals & Essential Oils on the afternoon of Tuesday November 16, Day Two of the conference (1330-1550 hrs.).

In his presentation, Dr. Fekete will discuss how large molecule biopharmaceuticals such as monoclonal antibodies (mAbs), antibody-drug-conjugates (ADCs) and other related products that have hitherto been characterized using traditional liquid chromatography techniques – reversed phase, ion-exchange and hydrophilic interaction chromatography – can now be analyzed using low-dispersion, bio-inert UPLC systems with newest generation of stationary phases. These methods, combined with advanced 3D modeling software enabled in DryLab®4, can deliver reduced sample use, increased sample throughput and superior overall method performance.

State of the art columns

Dr. Fekete will demonstrate the merits of using both modeling software (DryLab®) and modern instrumentation and novel columns to achieve streamlined method development for therapeutic proteins, based on several intact antibody, sub-unit and released glycan analysis case studies. He will also highlight several practical advantages, including automation of experiments, systematic comparison of different chromatographic columns and possibilities to serially couple columns for improved separation of large solutes.

He will conclude by discussing latest state-of-the-art column formats, allowing for sub-minute protein separations in both RP-, IEX-modes; and novel elution approaches – multi-isocratic and negative gradient segment – allowing almost infinite selectivity.

Creating design spaces

In partnership with the Massachusetts-based Waters Corporation, Molnár-Institute’s booth at the EAS symposium will present the state-of-the art connectivity offered by the DryLab®4 and Empower® software packages.

The Molnár-Institute team at EAS will also present details of their own software development, the Design Space Comparison Module that provides a systematic approach to find alternative (replacement) columns, allowing instant comparisons between Design Spaces obtained on different stationary phases to identify the Common Space where all sample components are separated with sufficient selectivity and resolution.

International Conference on Advances in Pharmaceutical Drug Development, QualityControl and Regulatory Sciences (DDRS) presence

Molnár-Institute will also be an exhibitor at DDRS Budapest, with a booth in the Exhibition Zone at the conference venue, the Ensana Thermal Hotel, again showcasing DryLab® 4 and its many modules.

Founder and President Dr. Imre Molnár and senior scientist and DryLab® specialist Mr. Arnold Zöldhegyi will represent the Institute in Budapest.

“We have been committed to attending both these events in person,” commented Magdalena Marinski.

“We are pleased that we have managed to deploy our small team to both Europe and the USA to be at both events simultaneously,” said Ms. Marinski.

About MOLNÁR-INSTITUTE

Founded in 1981, Molnár-Institute develops DryLab®4, a software for UHPLC modeling for a world-wide market. Its powerful modules allow for the most sophisticated method development as required across pharma industries. Analytical scientists use DryLab® to understand chromatographic interactions, reduce runtimes, increase robustness, and conform to Analytical Quality by Design (AQbD) standards.

The Molnár-Institute is a registered vendor to the US FDA, CDC and other regulatory bodies. DryLab® has pioneered AQbD long before regulatory agencies across the world encouraged such submissions. Widely implemented by thought leaders, the software contributes substantially to the paradigm shift towards a science and risk driven perspective on HPLC Quality Control and Assurance.

Further information at: http://www.molnár-institute.com/

About EAS 2021

The Eastern Analytical Symposium and Exposition (EAS) is held each year to provide professional scientists and students working in the Eastern USA with continuing education in the analytical and allied sciences through the presentation of symposia of papers, workshops, and short courses.

For more than 50 years, the EAS Technical Program has provided cutting-edge information for the analyst with research presentations on practical and novel technologies. The symposium now typically contains over 450 papers on a wide variety of subjects, from pharmaceutical analysis to art conservation, emphasizing practical applications of a wide range technologies including Liquid chromatography, Raman spectroscopy, microscopy, and sensors in solving real-life problems,

While the 2020 Symposium was a four-day virtual online event, due to the coronavirus emergency, EAS 2021 will be a three-day physical event, opening November 16 2021 at the Crowne Plaza Princeton Conference Center in Plainsboro, NJ. The 2021 conference will be themed “Curiosity, Chemistry & Perseverance” with co-located exhibition of analytical science apparatus and supplies.

The event is organised by EAS with further information available at: https://s7.goeshow.com/eas/annual/2021/index

About DDRS 2021

The International Conference on Advances in Pharmaceutical Drug Development, Quality Control and Regulatory Sciences (DDRS) is one of Europe’s most prestigious drug research conferences, examining a complete scale of scenarios from drug development, quality control, the regulatory challenges, and the practical use and handling of complex drug products for a broad range of dosage forms.

DDRS 2021, an integral part of Budapest’s Semmelweis University 250-year jubilee event series, is a . three-day event opening November 15 at the Ensana Thermal Hotel on Margaret Island, in the green heart of Budapest, close to the city’s  iconic UNESCO-protected Music Fountain and Water Tower.

The conference, expected to attract participants from 48 countries on five continents, will form a follow-up to the successful series of International Regulatory Workshops on Bioequivalence, Bioanalysis, Dissolution and Biosimilarity (BEW Series) and the International Symposium on Scientific and Regulatory Advances in Biological and Non-Biological Complex Drugs: A to Z in Bioequivalence (SRACD Series). DDRS 21 will address new trends in pharmaceutical, regulatory science of biological and non-biological complex drugs (NBCDs) and the challenges for their correct use. Experts will also highlight COVID-19 vaccine developments and challenges.

The event is primarily organized by Budapest Semmelweis University, Department of Pharmaceutics, in co-operation with the Committee on Pharmaceutical Sciences, the Working Committee on Separation Sciences of the Hungarian Academy of Sciences (MTA) and Non-Biological Complex Drugs Working Group (NBCD) and Hungarian Societies for Pharmaceutical Sciences (HSPS), Experimental and Clinical Pharmacology (HUPHAR), and Separation Sciences (HSSS).  Further information at: https://ddrs2021.hu/.

Resources

Click on Molnár-Institute Method Development Services for further information.