L.B. Bohle White Paper – Dry Granulation

The latest White Paper from L.B. Bohle provides a technical overview of roller compaction (dry granulation) as a continuous process to refine the granule particle size of powders for tableting and other pharmaceutical products.

The paper explains the dry granulation process of crushing and sieving to obtain desired particle size distribution (PSD).

It then reviews the advantages of dry granulation over wet granulation, which can only be done as a batch process.

The paper reviews the various characteristics of different roller compaction systems, including roller arrangement (horizontal, vertical, or inclined), as well as fixed or variable gap, roller sizes and surface finishes. The implications of roller speed and drive systems are also discussed.

The paper covers The various engineering and design features of the L.B. Bohle BRC Series Roller Compactors, including their electromechanical drives, force-measuring adjustment with internal sensors, and ingenious machine design that facilitates handling, shortens assembly procedure and speeds changeovers are discussed in the paper.

Finally, the paper reviews the need for high containment options in dry granulation to facilitate handling of highly potent active pharma ingredients (HPAPI), such as integrated isolator unit, vacuum monitoring, glove box operation, containment port for flake sample collection, and residue-free removal of product with integrated wash-in-place (WIP) capabilities.

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