By L.B. Bohle
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L.B. Bohle VMA Single Pot Granulator
Single-pot granulation combines mixing, high-shear wet granulation and drying by carrier gas, vacuum, or microwave, into a single-station process, all carried out within one process bowl. This granulation technology has various advantages, including efficiency, convenience, compact footprint, containment, and safety, that have for decades made it a favored solution for the pharmaceutical industry.
L.B. Bohle’s VMA range of Single Pot Granulators includes R&D systems for small production volumes as well as production-scale systems that can work alongside its other top-of-the-line granulation solutions such as BFS fluid bed systems, and BRC roller compactors. These technologies offer efficient, safe, and environmentally friendly production processes, perfect for manufacturing solid dosage forms in the pharmaceutical industry.
VMA Single Pot Granulator design and features
The VMA product range includes classic single-pot granulators with agitator and chopper units and a top drive. Twin stirrers produce the shearing action and loosen the product. This helps to prevent clumping and ensures that the resulting granules are of optimum quality. The double shell process bowl at the core of the VMA design offers very high containment levels and full GMP compliance.
The main aggregates are filled into the granulator through the port integrated into the upper lid of the top drive granulation pot. Processed granules are then emptied through a cone-shaped BTS 200 sieve via the floor outlet into an intermediate bulk container.
Recipe-controlled machine cleaning is carried out automatically after each batch, which can range from 20 to 960 litres in size, depending on VMA Single Pot Granulation model.
The high containment and vacuum process of the VMA design make it suitable for use in ATEX inflammable or explosive environments.
L.B. Bohle VMA Single Pot Granulation Benefits
The VMA Series of L.B. Bohle Single Pot Granulators offer pharmaceutical manufacturers a set of clear and tangible benefits that include:
- Safe production inside a closed bowl in a vacuum
- High mixing and granulation efficiency (even for low doses of active agents at below 1%)
- Low energy consumption: Drying at low temperatures
- Easy operation and cleaning, as well as quick product changes
- Efficient solvent recovery through cooling water
- Compact footprint with potential for through-wall mounting.
VMA Single Pot Granulator Range
The following list provides an initial overview of the various production scale VMA single pot granulation systems, ranging from the laboratory scale VMA 70 to the high capacity industrial scale VMA 1200.
Full range details are contained in the VMA product brochure, available online for download (see Resources).
Resources
Click on L.B. Bohle VMA Single Pot Granulators for further details.
Click on L.B. Bohle Products & Processes Portfolio to learn more.
Click on White Papers and Product Brochures to access free downloads (registration required).
Visit Bohle Technology Center and Service Center virtually in a 360° tour.
VMA 600 Single Pot Granulator from L.B. Bohle, showing compact design, double shell process bowl, top loading port and lower emptying mechanism including BTS conical sieve.
VMA 600 Single Pot Granulator with process bowl lowered to reveal mixing paddle (center) with high shear granulator blades (right).
VMA 600 Single Pot Granulator in through wall installation showing lower sieving outlet hinged away for emptying and cleaning, with cooling water inlets and outlets for trolley-mounted pump (left), and remote control station (right) for operator convenience and safety.
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