High-Shear Granulator – Precision Granulation for Pharmaceutical Excellence

In pharmaceutical production, achieving consistent granule quality is essential for ensuring the efficacy and stability of solid dosage forms like tablets and capsules. L.B. Bohle, a global leader in pharmaceutical processing technology, has developed the GMA Series High-Shear Granulator, a state-of-the-art system designed to optimize granulation efficiency, improve product uniformity, and enhance overall manufacturing performance.

Understanding High-Shear Granulation

High-shear granulation is a key process in pharmaceutical manufacturing that converts fine powders into densely packed, flowable granules by mixing them with a binding liquid. This process enhances powder compressibility and uniformity, leading to improved tablet hardness, dissolution rates, and dosage consistency.

Unlike traditional granulation methods, high-shear granulation achieves rapid and controlled particle formation through an intensive mixing action generated by a high-speed impeller and chopper blades. This method is widely preferred for its speed, efficiency, and ability to produce high-quality granules suitable for large-scale pharmaceutical production.

The L.B. Bohle GMA Series: Cutting-Edge High-Shear Granulation Technology

L.B. Bohle’s GMA Series High-Shear Granulators are designed to meet the stringent demands of pharmaceutical manufacturing. These machines provide exceptional process control, ensuring consistent batch-to-batch granule properties while minimizing product loss and processing time.

Key Features & Design Innovations

The GMA High-Shear Granulator stands out due to its innovative engineering and user-friendly design, featuring:

• Cylindrical Process Bowl with Double-Dished Heads: Ensures even distribution of the granulation liquid, optimizing the granule formation process.
• Precision-Engineered Agitator & Chopper Blades: Facilitate thorough mixing and prevent excessive granule growth.
• Electrically Powered Lifting System: Allows seamless loading and unloading, improving operational efficiency.
• Closed-System Design: Enhances containment, reducing contamination risks and improving operator safety.
• Advanced Process Monitoring: An HMI-integrated camera system enables real-time observation, ensuring precise control over granulation parameters.
• Pressure-Surge Resistance: The system can withstand pressures up to 12 bars, with reinforced tank-sealing spindles ensuring safety during unexpected pressure surges.

Optimized Performance for Pharmaceutical Applications

The GMA High-shear Granulator Series is designed for through-the-wall installation, allowing for efficient space utilization and seamless integration with other pharmaceutical processing equipment. The rear-mounted switch cabinet enhances safety and streamlines batch operations, making it an ideal choice for both R&D and large-scale production environments.

Why Choose the L.B. Bohle GMA High-Shear Granulator?

Pharmaceutical manufacturers worldwide rely on L.B. Bohle’s GMA High-Shear Granulators for their efficiency, reliability, and superior performance. Here’s why:

• Uniform Granule Formation – Ensures precise particle size distribution for improved tablet consistency.
• Reduced Processing Time – High-speed mixing accelerates the granulation process.
• Minimal Fluid Consumption – Optimized design reduces the amount of granulation liquid needed.
• Easy Discharge & Cleaning – Impeller-assisted discharge and rapid fluid drainage simplify operations.
• Customizable Granulation Control – Operators can fine-tune parameters for batch-specific needs.
• Regulatory Compliance – Meets GMP (Good Manufacturing Practice) and industry standards.

A Solution for Every Scale

L.B. Bohle offers a versatile range of GMA High-Shear Granulators, to suit pharmaceutical companies of all sizes. From small-batch R&D applications to high-capacity industrial production, there is a model to match every requirement.

The GMA Series High-Shear Granulator by L.B. Bohle represents the pinnacle of pharmaceutical granulation technology. By combining precision engineering, innovative process control, and advanced safety features, it provides an unparalleled solution for manufacturers aiming to enhance product quality and streamline production.

With its reputation for efficiency, reliability, and compliance with industry standards, the L.B. Bohle High-Shear Granulator is a vital asset for pharmaceutical companies committed to achieving excellence in solid dosage manufacturing.

Resources

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