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    Brevetti Angela to present latest Prefilled Syringe solution to BFS IOA American meeting

    news-releasesBrevetti Angela Srl
    October 4th 2022

    Vicenza, Italy: – Leading manufacturer of high technology pharma packaging machinery, Brevetti Angela Srl, will showcase its most recent developments in the field of injection devices at October’s BFS International Operators Association American Meeting in Columbia, South Carolina.

    This year it will outline the stages of the world-leading experience in production of injection devices, that led to the innovative O-Flow prefilled syringe produced by sister company 3CK,. O-Flow represents the 5th Generation of Brevetti Angela-developed prefilled syringe.

    A long history of R&D

    As a leading member of the BFS IOA, Brevetti Angela has co-sponsored all the association’s events for the past decade and more. As usual, it will contribute to the science and technology conference agenda with Sales & Marketing Director Rajeev Kabbur presenting ‘Update on new generation of prefilled syringes ‘ on the first day of the conference (October 12, afternoon session).

    Brevetti Angela has been manufacturing Blow Fill Seal machines for 45 years. While the first SYFPAC machines were mainly produced for bottles, vials and ampoules, in the late 1990s Brevetti Angela started researching on Prefilled Syringes and produced the first BFS machine for injection devices. Research on this new field never stopped since that first machine, and saw the birth of several generations of prefilled syringes. The first device was a squeezable, single-use container; it was followed by a two-component syringe with embedded needle, and by a more standard-looking device with plunger, with volumes ranging from 0.5ml to 20ml.

    Silicone -free advantages  

    Mr. Kabbur will explain how one of the main issues with prefilled syringes is the presence of silicone oil, which is necessary to smooth  plunger movement, but also poses problems such as formation of submicron- and micron-size silicone oil droplets when syringe is agitated, potentially leading to early- and late-stage immune responses.

    The solution proposed by Brevetti Angela in collaboration with 3CK overcomes such problems by eliminating the presence of silicone oil. A syringe with no silicone oil will be able to minimize subvisible particles in the administered drug while also completely eliminating break loose force, making plunger movement much easier and more controlled. The new syringes also use materials with lower protein adsorption properties to suppress protein aggregation.

    Enhanced compliance

    When designing an injection device, it is important to keep an eye to compliance: aspects like a compact form, improved dosing accuracy, and independence from expensive sterile secondary packaging can be particularly important. The latest generation of syringes that Brevetti Angela have developed with 3CK have been designed to have large printable surface available to print product related information by laser with very high contrast. Their design also allows to be formable from several different materials, including PP, COC, COP, Multilayer, TPE, TPV, and Bromobutyle that can both reduce oxygen and moisture transmission and also help reduce extractables and leachables.

    “As the specific association for Blow Fill Seal manufacturing, the BFS IOA American meeting is also a key date on our calendar,” commented Mr. Kabbur.

    “As one of the world’s leading BFS players, we always look forward to these meetings as a great platform to present our latest innovations and hear about current trends and demands in the market,” he added.

    About Brevetti Angela

    Brevetti Angela Srl is one of the world’s leading manufacturers of pharma primary packaging machinery, specializing in production of Blow Fill Seal (BFS) machinery for the aseptic packing of liquids in purpose formed plastic bottles, vials and parenteral forms. Brevetti Angela platforms are ideally suited to aseptic filling of pharmaceutical solutions and can also be applied to food & beverages, cosmetics or cyanoacrylates filling.

    Founded by Francesco Consolaro in 1977, the company remains based in Arzignano, in the province of Vicenza in northeastern Italy. Over more than four decades, Brevetti Angela has been guided by a vision of following a path of continuous innovation based on ensuring customer satisfaction and quality of finished product, with a mission to provide primary packaging solutions that are flexible, versatile and also reliable and easy to maintain.

    The company is particularly known for its range of advanced and patented SYFPAC® BFS machines designed and engineered to achieve the highest quality aseptic packaging of sterile pharmaceutical fluids for small volume vials, bottles, and pre-filled syringes.

    One of the key enablers for very high quality at Brevetti Angela is its emphasis on keeping all vital processes ‘in house’ at Arzignano where all facilities meet CE standards and since 2008 have been certificated to ISO 9001:2008 quality standards.

    About BFS IOA American Meeting 2022

    The Pharmaceutical Blow-Fill-Seal International Operators Association (BFS IOA) is an international industry association for pharmaceutical and associated companies with direct or indirect involvement with Blow-Fill-Seal (BFS) manufacturing. BFS IOA is a non-profit organization financed by subscription of more than 60 member companies worldwide and by sponsorships from the industry.

    The association’s American meeting for 2022 is a two-day event opening October 12 at the Dominion Energy South Carolina conference center in Columbia SC.

    The event will include presentations from Brevetti Angela and other leading manufacturers of BFA technology, along with a report from the 2022 AGM held in Lyon, France, and BFS IOA Board report on plans for 2022/2023. There will also be three workshops, including focus on Defect Classification and Annex 1 Compliance.

    The event is organised by the BFS International Operators Association with further information at:–Columbia-SC-USA


    Click on O-Flow: The next generation of prefilled and prefillable syringes for further information.
    Click on 3CK Medical Devices to view video.


    Learn all about Blow Fill Seal (BFS) technology for your aseptic packaging needs

    Brevetti Angela to present latest Prefilled Syringe solution to BFS IOA American meeting

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