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    Brevetti Angela and 3CK – Synergy for medical devices

    products-servicesBrevetti Angela Srl
    January 23rd 2025

    Brevetti Angela works closely with 3CK, also based in northern Italy, in combining capabilities, technology, and expertise to develop new generations of medical devices.

    The partnership is based on Brevetti Angela’s 50 years of accumulated experience in Blow-Fill-Seal (BFS) technology for the instant plastic forming, filling and sealing of pharmaceutical bottles and vials under aseptic conditions. Since 2021, this knowledge has been leveraged through 3CK into the development of novel parenteral and delivery devices.

    Prefilled syringe innovation

    In particular, 3CK has become a specialist in the design and development of innovative prefilled and prefillable syringe formats.

    Prefilled syringes are being embraced by global pharma as having decisive advantages over syringes that need to be charged from vials, including greater convenience, easier administration, simplified handling and storage, lower risks of cross-contamination and total avoidance of over- or underfilling.

    These advantages become even more pronounced when it becomes possible to form prefillable syringes in plastic as part of an integrated and contained manufacturing and filling process carried out on BFS machines.

    One previous disadvantage of prefilled plastic syringes was the break-loose force needed to start the movement of the plunger, making injections harder to administer. This required silicone oil as a lubricant coating on the plunger seal, raising multiple issues.

    This is a problem that 3CK tackled and overcame with its pioneering O-Flow syringe which uses advanced materials and design to eliminate the need for silicone lubrication. Additionally, the O-Flow concept is adaptable to a wide range of sizes and volumes and was designed from inception to be easily manufacturable and fillable.

    BFS at the core

    Brevetti Angela provided the other half of this equation by developing a dedicated filling machine, an aseptic filling system specifically designed to accommodate the O-Flow design.

    Aseptic filling is Brevetti Angela’s specialty, shaping the design and engineering of its pharma-oriented SYFPAC® Blow Fill Seal machines that have been progressively developed over almost half a century. Production of the first prefilled syringes on a SYFPAC® platform dates back to 1999 and this capability has seen several developments over the years and five distinct generations of prefilled injection devices.

    The latest of these is 3CK’s latest innovation, the C-PAD injection device. Developed in collaboration with PATH in the USA to meet the needs of developing regions, the C-PAD is a single-use disposable syringe that comes pre-filled with sterile needle already incorporated. This is an auto-disabling device, designed for single use to avoid any possibility of cross-contamination or under/overdosage. There is no plunger, the device only needs to be squeezed for easier self-injection, making it ideal for discreet ‘grass roots’ applications such as contraception or mass vaccination campaigns.

    The SYFPAC® DUO™ Revolution

    Today, SYFPAC® BFS machines have taken a giant step further forward with the development of the revolutionary SYFPAC® DUO™ platform that is highly adapted to the BFS production of prefilled syringes for the administration of vaccines and other temperature-sensitive drugs.

    With its innovative combination of closed parison aseptic isolation with ability to automatically add inserts inside the parison, plus the adaptability and fast changeovers of easily swapped inserts and molds, DUO™ also supports manufacture of a very wide range of syringe formats.

    SYFPAC® DUO™ also features a very small footprint, modular design, easy scaling up and advanced data integration. These make it ready for a future world of smart micro-factories in which pharma production happens at increasingly granular levels.

    New generations

    Together, Brevetti Angela and 3CK have been developing new generations of injection devices and the advanced platforms needed to produce them.

    This is a collaboration based on shared experience, heritage, and passion for the opportunities opened up by BFS technology. When people with the same background knowledge and expertise work on different aspects of a challenge, there is less room for misunderstandings and missteps.

    New generations are also evident on the human side with Brevetti Angela’s family ethos mirrored in the sons and nephews of the founder represented in the two companies’ leaderships. In this way, the younger generation provides fresh impetus and innovation based on inherited wisdom and experience.

    Collaboration also extends to customer partnerships, consulting closely on client needs to design solutions precisely adapted to specific needs and circumstances, continuously adapting the manufacturing process to avoid needless complications, simplify the design, and optimize user-friendliness.

    Resources

    Click on Brevetti Angela SYFPAC® BFS Technology for further information.
    Click on 3CK O-Flow to learn more.
    Click on Fastest Smallest Safest BFS Machine for more about SYFPAC® DUO™.

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    Brevetti Angela and 3CK – Synergy for medical devices
    Brevetti Angela and 3CK – Synergy for medical devices
    Brevetti Angela and 3CK – Synergy for medical devices

    Brevetti Angela Srl

    Contact Information
    Address: Via Industria 99, 36071 Arzignano, Vicenza, ITALY
    Telephone No: +39 0444 474200
    Email Address: [email protected]

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