Contact Supplier

Contact Supplier

To get in touch with Bachem AG, simply fill out the form below.

    Subscribe to Supplier

    Subscribe to Supplier

    Bachem enters strategic collaboration with Lilly to manufacture oligonucleotide-based drug substances

    news-releasesBachem AG
    June 15th 2022

    Bubendorf, Switzerland: –Peptide technology specialist Bachem has announced a strategic collaboration with Lilly to develop innovative and efficient processing solutions for the manufacture of oligonucleotide-based drug substances.

    The annual order volume has the potential to achieve around CHF 100 million (USD 100.34 m), depending on Bachem reaching certain milestones and definite volumes specified by Lilly.

    The collaboration is an important step in further expanding both companies’ current technology platforms and abilities to innovate and grow oligonucleotide processes, adding significant new global manufacturing capacity for oligonucleotide-based medicines for patients.

    Engineering expertise

    Under the terms of the agreement, Bachem will provide the appropriate engineering infrastructure and expertise to implement Lilly’s novel oligonucleotide manufacturing technology. Furthermore, Bachem will provide R&D and production personnel at its facilities in Bubendorf, Switzerland, for the development and manufacture of GMP-grade material for Lilly’s oligonucleotide-based investigational medicines using Lilly’s technology.

    Lilly commits to placing manufacturing projects with Bachem over the next seven years with increasing material supply demands following successful implementation of Lilly’s oligonucleotide manufacturing technology. The annual order volume has the potential to achieve around CHF 100 million, depending on Bachem reaching certain milestones and definite volumes ordered by Lilly.

    Tailored solutions

    Bachem CEO Thomas Meier commented: “We are excited about the prospects that our strategic collaboration with Lilly has for innovating how oligonucleotides are manufactured. Investigational medicines based on synthetically accessible oligonucleotides hold great promise for patients suffering from a variety of diseases and we are proud to collaborate with Lilly in unlocking the potential of this new modality.

    “This collaboration between Bachem and Lilly is an example of how the biopharma and CDMO industries can work together on innovative medicines that are developed and manufactured at scale and of high quality for patients in need. Our aim with this collaboration is to jointly develop tailored engineering and equipment solutions for oligonucleotides, thus improving quality and reducing manufacturing cost and time to market.” Mr. Meier added.

    Reaching new patients

    Therapeutic oligonucleotide NCEs are based on short single or double-stranded fragments of DNA or RNA. Because of their unique properties, oligonucleotides as therapeutics open ​access to previously “undruggable” targets not ​accessible with small molecule drugs or biologics. Initially used within orphan diseases with small patient populations, scientific progress has led to a broad expansion of drug development projects on oligonucleotide-based therapeutics in the biopharma industry.

    This increasing demand and the promise of addressing larger patient groups require the production of oligonucleotide-based active pharmaceutical ingredients (APIs) at a larger scale and with new processing solutions.

    About Bachem

    Bachem is a leading, innovation-driven company specializing in the development and manufacture of peptides and oligonucleotides. With over 50 years of experience and expertise, Bachem provides products for research, clinical development and commercial application to pharmaceutical and biotechnology companies worldwide and offers a comprehensive range of services.

    Bachem operates internationally with headquarters in Switzerland and locations in Europe, the US and Asia. The company is listed on the SIX Swiss Exchange. For further information, see www.bachem.com.

    Resources

    Click on Bachem enters strategic collaboration with Lilly to manufacture oligonucleotide-based drug substances to see original release.
    Click on Expanding into oligonucleotides  to watch interview.
    Subscribe to Bachems Newsletter to receive the latest updates.

    Bachem enters strategic collaboration with Lilly to manufacture oligonucleotide-based drug substances

    Strategic collaboration with Lilly will further enhance Bachem’s sophisticated oligonucleotide production capabilities.

    Contact Bachem AG

    Simply fill out the form below to contact Bachem AG now.

    Send Bachem AG a Message