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    Pharmatrans DICOM SANAQ SP204 proprietary excipient for Direct Compression containing alkaline agent

    products-servicesPharmatrans SANAQ AG
    April 9th 2020

    Pharmatrans Sanaq has extended its DICOM SANAQ® range of high functionality co-processed excipients with the introduction of DC® SP 204 as a co-processed excipient optimized for direct compression and containing an alkaline agent. This makes it especially suitable for acid sensitive APIs.

    DC® SP 204 incorporates a large surface area of Light Magnesium Oxide to provide enhanced protection and stability to acid labile active pharmaceutical ingredients from a 360o alkaline environment.

    DICOM-DC® SP204 Features

    DICOM-DC® SP204 is a proprietary co-processed excipient containing Microcrystalline Cellulose, Light Magnesium Oxide, Sodium Starch glycolate, pre-gelatinized starch and Maize starch.

    The presence of the alkaline microenvironment is essential in case of The large Magnesium Oxide surface area in DICOM-DC® SP204 creates a 360° alkaline microenvironment at pH 9.5-11.0. This is essential in formulations involving acid labile drugs (e.g. Pantoprazole) to provide enhanced protection to the active ingredient.

    DICOM-DC® SP204 also exhibits high bulk density making it suitable for formulation of high weight tablets.

    DC® SP204 Benefits

    As part of the Pharmatrans mission to produce ‘Pharmaceutical Excipients focused on your formulation needs’, DICOM-DC® SP204 is engineered to provide directly identifiable and quantifiable user benefits.

    In particular, the incorporation of Light Magnesium Oxide into the co-processed excipient overcomes a number of previous problems.

      • Light Magnesium Oxide is a very fluffy material that is difficult to incorporate directly into a tablet formulation
      • Segregation tendency leads to weight variations, unstable formulations, and a non-uniform alkaline microenvironment
      • The inconsistent granular mix can lead to improper die filling and tooling damage without special coatings.

    In contrast, use of DC® SP204 offers:

    • Uniform alkaline protection from all sides
    • Direct compression at high speed with uniform weight and quality attributes
    • Enhanced stability for acid labile APIs
    • Higher product quality in being able to form robust tablets with reduced friability
    • Reduced tooling wear and damage through indirect contact and protection from other excipients in the co-processed mix
    • No special coating requited for tooling
    • Hugh bulk density allows formulation for high tablet weight using smaller die or high fill weight in smaller capsules

    Resources

    Click on DICOM SANAQ portfolio for a summary of available blends.

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    Pharmatrans DICOM SANAQ SP204 proprietary excipient for Direct Compression containing alkaline agent
    Pharmatrans DICOM SANAQ SP204 proprietary excipient for Direct Compression containing alkaline agent

    Pharmatrans SANAQ AG

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    Address: Gewerbestrasse 18, CH-4123 Allschwil, Switzerland
    Telephone No: +41 61 225 9000
    Email Address: [email protected]

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