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Pharmatrans SSG and PVP-P disintegrants
Pharmatrans SANAQ® offers SSG sodium starch glycolate and PVP-P crospovidone as super disintegrants that can radically accelerate oral solid dose (OSD) dissolution and drug delivery.
These super disintegrants are particularly useful in tablet, capsule and granule formulations.
Sodium Starch Glycolate (SSG), the sodium starch glycolate of potato starch, is a chemically modified (sodium hydroxide and chloride acid) derivative of starch that can be used as a hydrophobic lubricant in tablet formulations to reduce disintegration time and accelerate delivery of API.
SSG SANAQ® is a Type A Sodium Starch Glycolate starch derivative, with chemical and physical identities meeting the latest standards defined by pharmacopeias Ph. Eur., USP-NF, and BP. It can be used as disintegrant for tablets direct tableting and wet granulation, as well as for, capsules and granules.
SSG SANAQ® is recommended in a concentration of 2-8% of the total weight.
The effects of SSG SANAQ® as a disintegrating agent are caused by the rapid absorption of water and the enormous swelling properties of the SSG SANAQ® particles. Non-dissolvable in water, the swollen SSG SANAQ® particles remain intact, avoiding formation of viscous film, to consequently cause the rapid disruption of the tablet into its original components. Hence, SSG SANAQ® improves the release and the absorption of the active ingredient.
SSG SANAQ® is highly stable with its disintegration enhancement effect remaining potent even after prolonged storage.
SSG SANAQ® can also be used as a hydrophobic film covering the tablet ingredient particles. In this case, SSG SANAQ® guarantees a rapid absorption of water and due to the excellent swelling property a fast and complete disintegration of the tablet.
SSG SANAQ® Type A Specifications:
PVP-P SANAQ® is a crospovidone-class super disintegrant, this is comprised of cross-linked Polyvinylpyrrolidone that can be used as a disintegrant in tablets and hard gelatin capsules.
PVP-P SANAQ® can also be applied as a stabilizer for oral and topical suspensions, as a way to improve dissolution and bioavailability, and as a filtration aid.