MEGGLE Captopril Case Study: How excipient choice can combat tablet deformation

Pharmaceutical lactose specialist MEGGLE has released a technical Case Study on masking the effects of API-related elastic deformation in tableting.

The article documents findings from a technical study using the antihypertensive Captopril as a research sample for a drug with fundamentally high elastic deformation properties that can affect compression and consequent tablet robustness.

This study highlights the tableting obstacles encountered in conventional Captopril formulations and shows how the correct choice of lactose-based technological excipients can promote compression improvement, making scale-up more effective and robust. The study also identifies potential enhancements to drug effectiveness.

Click below to download full study.