Applikon adds 3L customizable single-use bioreactor to AppliFlex ST family

news-releasesApplikon Biotechnology B.V.

January 28th 2020

Delft, The Netherlands: – Dutch-based upstream bioprocess equipment specialist Applikon Biotechnology B.V. (Applikon) has extended its innovative family of AppliFlex ST customizable single-use bioreactor systems with a three liter version for cell culture applications.The AppliFlex ST is a fully customizable and scalable stirred tank single-use bioreactor that uses 3D printing technology to provide bioreactor design that is uniquely configured to each individual process, including custom impeller design, inlets, outlets and various port connections.

On-demand disposable bioreactors

AppliFlex ST’s 3D printing production technology allows multiple options, like for example ‘Designed on Demand’ impellers in Helical, Hydrofoil, Marine or Rushton formats. Further, it guarantees complete reproducibility between the different customized bioreactors, providing exact identical conditions between runs. AppliFlex ST is designed to be easy to open at end of run to facilitate a simple transfer to downstream processing.

The AppliFlex ST allows for bioreactors designs that were previously not available in a single use format. Applications where highly customized bioreactors are used can now benefit from the advantages of single use solutions, meaning quicker turnaround time and reduced risk of contamination.

“The AppliFlex ST is fully configurable. You can choose the type and number of impellers, the number of liquid and gas additions, different sample port connections, and the type of sparger that are most optimal for your process,” said Erik Kakes, International Sales and Marketing Director at Applikon.

“AppliFlex ST users are freed from the need for blind plugs since each bioreactor is wholly built to their specific process”.

AppliFlex ST single-use product range

The AppliFlex ST (stirred tank) 3L bioreactor joins a growing range of Applikon single-use systems. AppliFlex bioreactors are delivered pre-sterilized and ‘ready to go’ to save time during culture setup.

The single-use bioreactors are 1:1 interchangeable with Applikon’s glass bioreactors of the same volume and are designed according to identical high Applikon quality standards. All measurement and control auxiliaries are completely interchangeable between the single-use and glass bioreactors, saving customers time, effort and cost in switching between single-use and multi-use systems

Integrated solutions

All systems can be supplied with measurement and control of key bioprocess parameters using customer’s choice of software solution. Applikon’s multi-reactor interface allows for simple parallel processing. Embedded control can be supplemented with Lucullus PIMS automation solution or Applikon’s own open architecture DeltaV™ based V-Control package.

The AppliFlex ST can be supplied with optical or classical sensor technologies. Optical sensors include pH and Dissolved Oxygen making start up and operating the systems very easy. Classical sensors cover an even wider range of calibrations that include Biomass (capacitance and optical), Red Ox and weight.

The AppliFlex ST works with auto samplers (like Flownamics and MAST) to easily connect analytical devices and automate the sample processing. Further, there are several perfusion options for continuous bioprocessing.

About Applikon Biotechnology

Netherlands-based Applikon Biotechnology B.V. (Applikon) is a manufacturer that specializes in upstream bioprocess equipment for the life sciences industries. Its mission is to provide reliable solutions for the bioprocess market to enable improved quality of life.

Applikon’s core business is in the development and supply of advanced bioreactor systems from laboratory scale, to pilot, to production scale, partnering with customers to implement scalable platforms from initial screening through development and full-scale production for a global client base that includes pharma and biotech companies, food industry, CROs, CMOs, governmental and academic organizations.

Applikon designs, develops and assembles bioreactor systems, with all design and manufacturing conducted in-house. The Applikon portfolio covers key product and service areas including bioreactor cultivation systems, BioBundle turnkey systems, the unique BioSep Acoustic Perfusion System cell retention device, process control systems to automate bioprocesses and a range of proprietary AppliSens sensors, and automation (monitoring and data management) solutions.

Apart from its standard cultivation and turnkey systems, Applikon also offers Special Projects: custom solutions aimed at helping clients fulfill strategic needs such as long-term development, capability expansion and upscaling.

Applikon is headquartered at Delft in The Netherlands with subsidiaries in the UK, New Jersey and California, USA and a distributor network covering more than 35 countries.