Tumor Development and Animal Welfare in a Murine Xenograft Model

White Paper – Pipeline Biotech A/S
The Utility of Fecal Corticosterone Metabolites and
Animal Welfare Assessment Protocols as Predictive Parameters of Tumor Development and Animal Welfare in a Murine Xenograft Model

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Supplier White Paper: Tumor Development and Animal Welfare in a Murine Xenograft Model
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The Utility of Fecal Corticosterone Metabolites and
Animal Welfare Assessment Protocols as Predictive Parameters of Tumor Development and Animal Welfare in a Murine Xenograft Model

KIRSTEN ROSENMAJ JACOBSEN1, PERNILLE JØRGENSEN2, CHRISTIAN BRESSEN PIPPER3,
ASTRID MARGRETHE STEFFENSEN2, JANN HAU1 and KLAS S.P. ABELSON1
1Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark; 2Pipeline Biotech A/S, Trige, Denmark;
3Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark


ABSTRACT

The aim of the present study was to evaluate the utility of various non-invasive parameters for the prediction of tumor development and animal welfare in a murine xenograft model in male C.B-17 SCID (C.B-Igh-1b/IcrTac-Prkdcscid) mice. The study showed that body weight, food and water consumption, and an animal welfare assessment(AWA) protocol revealed marked differences between control and cancer lines as the size of the tumor increased. However, only the AWA protocol was effective in predicting the tumor size and the level of fecal corticosterone metabolites (FCM). FCM levels were, however, negatively-correlated to the AWA score, and the tumor size, both when evaluated on a given day and when accumulated over the entire period. In conclusion, the present study demonstrated that body weight and food and water consumption were negatively-affected as tumor developed but only the animal welfare protocol could be used to predict tumor size.

To read the full article, please click on the link below:
Tumor Development and Animal Welfare in a Murine Xenograft Model


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