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SIRION LentiBOOST™ non-cytotoxic transduction enhancer for lentiviral vectors

products-servicesSIRION Biotech GmbH
April 8th 2020

SIRION Biotech has developed LentiBOOST as a highly effective, non-cytotoxic transduction enhancer for lentiviral vectors in preclinical and clinical applications.

As a universally acting and receptor independent adjuvant, LentiBOOST can be applied to a wide range of clinically relevant cell types, making it a promising candidate to improve clinical transduction protocols for ex vivo gene therapies and CAR-T cell therapies.

With up to five-fold increases in transduction, LentiBOOST offers powerful benefits for biotech and pharma companies, drug developers, academic researchers seeking improved results in CAR-T clinical trials, cell therapy research and development studies.

LentiBOOST features

LentiBOOST is a highly effective, non-cytotoxic transduction enhancer for preclinical and clinical application of lentiviral vectors. As universally acting (receptor independent) adjuvant it can be applied to a wide range of clinically relevant cell types including CD34+ hematopoietic stem cells (HSCs), primary T cells and NK cells.

These unique features make it a promising candidate to improve clinical transduction protocols for ex vivo gene therapies and CAR-T cell therapies.

LentiBOOST features include:

  • Shows up to 90% improvements in lentiviral transduction efficiency.
  • Positive impact on cell proliferation for CD34+ and T cells.
  • Non-cytotoxic.
  • Increased vector copy numbers per cell.
  • Successful track record of integration into clinical trials (III and I/II) in the US and Europe.
  • GMP batch grades available.

LentiBOOST benefits

LentiBOOST’s powerful features and advantages deliver a series of user benefits:

  • Increased expression levels of therapeutic protein have favorable effects on success rates of clinical trials.
  • Better-optimized and more stable transgenic cell manufacturing allows reduced cost of final product.
  • LentiBOOST exhibits strong and durable therapeutic protein expression, in line with FDA/EMA criteria for ATMPs production.
  • Proven lack of cell toxicity and prior clinical applications expedite IND filings.
  • Availability of cGMP batch grades allow direct integration into clinical programs.

LentiBOOST variants

LentiBOOST is available in two versions:

  • LentiBOOST Pharma grade: intended for use in preclinical research and process development only.
  • LentiBOOST GMP grade: for use in clinical stage protocols, currently included in multiple Phase III and I/II clinical trials in Europe and North America.

Contacts

For quotes and detailed information on LentiBOOST™ technology, contact: lentiboost@sirion-biotech.com.
For licensing options for Clinical/Commercial Use and Development, contact: licensing@sirion-biotech.com.

Resources

Click on LentiBOOST Transduction Enhancer for detailed information.

SIRION LentiBOOST™ non-cytotoxic transduction enhancer for lentiviral vectors

Comparative demonstration showing LentiBOOST™ increases
transduction by a factor of 5

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