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Polypharma antimycotic drug dossiers
Polypharma Technologies & Sciences GmbH (Polypharma) can provide support for development of antimycotic medicines used to treat fungal skin, scalp and other conditions infections in human medicine.
These antimycotic drug dossiers can be used to empower potential producers across the Middle East and North Africa (MENA) region who are seeking fast track market-ready anti-fungal cream, ointment, liquid and other solutions to meet local and regional needs.
Antimycotic is the term used to describe a substance that inhibits or reverses the growth of fungi and that therefore is important as an antifungal medication.
Antimycotic medications are used to treat fungal infections in humans, most commonly affecting skin, scalp, feet and nails, typically available without prescription as OTC products.
Fungal Infections that anti-mycotics can treat include ringworm, athlete’s foot, toe and nail infections, thrush and some types of severe scalp itching and flaking.
Polypharma antimycotic dossiers
Polypharma’s extensive portfolio of generic human medicines available as pre-prepared dossiers includes a number of significant antimycotic drugs widely used in dermatology. These include:
- Terbinafin: Medicine administered in antifungal cream, gel or spray forms under brands forms such as Lamisil but also available in generic form to treat skin infections caused by a fungal yeasts, including athlete’s foot, fungal nail infections, ringworm, ‘jock itch’ infections in the groin area, or pityriasis versicolor scaly and discolored skin (often on torso or upper arms). and tummy). Terbinafine can also be prescribed in tablet form for more problematic infections.
- Nystatin: This antifungal medicine (brand name Nystan) is a powerful antimycotic substance usually only available on prescription to treat or prevent infections caused by a fungus (or yeast) that include oral thrush, and skin infections. Nystatin is usually orally administered as a liquid suspension but can also be mixed with steroids, antiseptics or antibacterials to form creams or ointments for topical administration.
- Neomycin: Neomycin is similar to other aminoglycosides in showing excellent activity against gram-negative bacteria and is partially effective against gram-positive bacteria. It is administered topically by cream or ointment to treat fungal skin infections and also orally to treat intestinal bacteria and in combination with dietary restrictions as treatment for hepatic encephalopathy, a brain condition caused by excess ammonia.
- Triamcinolone: From the corticosteroids class, triamcinolone is applied topically in ointment, cream, lotion, and spray formats to treat itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis and eczema. It can also be used in dental paste from to relieve mouth sores.
- Ketoconazole: An antimycotic substance that forms the basic active pharmaceutical ingredient for branded antifungal cream or shampoo products such as Dandrazol or Nizoral used to treat different types of fungal infections including athlete’s foot, jock itch groin infections, intertrigo sweat rash, or seborrheic dermatitis on the scalp. In prescription tablet or other forms, ketoconazole can also be used to treat pityriasis versicolor or the rare condition Cushing’s syndrome.
- Fluconazole: an antimycotic medicine used to treat infections caused by different kinds of fungus, particularly related to candida yeast, including various forms of thrush. Normally administered in oral capsule or liquid form, fluconazole (branded name Diflucan) can also be used to alleviate cryptococcal meningitis.
- Miconazole: First patented in 1968 and medically approved in 1971, miconazole features on the World Health Organization (WHO) List of Essential Medicines as an antimycotic cream or ointment to treat ring worm, pityriasis versicolor, and yeast infections of the skin. It has been marketed under a wide range of brand names including Monistat, Desenex, Daktarin and Fungimin. In orally administered forms, miconazole can also be used to treat oral or vaginal thrush , or the lip disorder angular cheilitis.
- Amphotericin B: Also on the WHO Essential Medicines list, amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis that can also be used to treat a wide range of systemic fungal infections, such as mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. It is typically administered by intravenous injection.
The above list refers only to those antimycotics already subject of fully-developed drug dossiers. Polypharma is also able to develop other antimycotic dossiers on request and after having carried out a specific feasibility study on the substance.