Polypharma anti-helminthic drug dossiers

Polypharma Technologies & Sciences GmbH (Polypharma) can provide support for development of antihelminthic medicines used to treat worm and parasitic-related infections that are in particular demand in tropical climates such as across the Middle East and North Africa (MENA) region.

These antihelminthic drug dossiers can be used to empower potential producers seeking fast track ways to develop veterinary medicines and human in oral solid dose and other forms to meet local market needs and empower MENA drug producers.

Antihelminthic agents

Anthelmintic is the term used to describe a drug used to combat infections of parasitic worms. This includes both flat worms such as trematode flukes, cestode tapeworms and nematode round worms.

These anti-helminthic agents are particularly relevant in veterinary treatments in tropical climates where parasites are a particular problem in agriculture.

Polypharma antihelminthic dossiers

Polypharma’s extensive portfolio of generic veterinary and human medicines include a number of significant antihelminthic drugs.

Veterinary medicines include:

• Albendazole: used to treat infections caused by worms. It works by keeping the worm from absorbing sugar (glucose), so that the worm loses energy and dies. Albendazole is specifically used to treat neurocysticercosis, an infection of the nervous system caused by pork tapeworms, as well as cystic hydatid disease of the liver, lung, and peritoneum, an infection caused by dog tapeworms.
• Febantel: broad-spectrum antiparasitic active ingredient from the pro-benzimidazole chemical class used as an anthelmintic for veterinary use against roundworms and tapeworms in dogs, cats, horses, cattle, sheep, goats, pig and poultry.
• Fenbendazole: a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, Taenia genus tapeworms, and pinworms. Typically administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.
• Ivermectin: routinely used to control parasitic worms in the gastrointestinal tracts of cattle that can also be used as a prophylaxis against heartworm in dogs and sometimes as an acaricide in reptiles.
• Oxfendazole: broad spectrum benzimidazole anthelmintic mainly used to protect livestock against roundworm, strongyles and pinworms. Oxfendazole is the sulfoxide metabolite of fenbendazole.
• Piperazine Citrate: Low-toxicity anthelmintic that is highly effective against ascarids, such as dog worm, roundworm and hookworms, that acts to block neuromuscular transmission in the parasite by hyperpolarizing the nerve membrane, leading to flaccid paralysis and blocking succinate production, allowing the worm to be expelled by peristalsis.
• Triclabendazole: a further member of the benzimidazole family that is on the WHO List of Essential Medicines as proven effective as an oral anti-helminthic medication used to treat fascioliasis and paragonimiasis.

Human medicines include

• Albendazole
• Pyrantel pamoate
• Albenza
• Biltricide

The above list refers only to those antihelminthics already subject of fully-developed drug dossiers. Polypharma is also able to develop other antihelminthic dossiers on request and after having carried out a specific feasibility study on the substance.

Resources

Click on Polypharma generic veterinary medicine dossiers for further information.
Click on Generic drug dossier development  for further information.