Pharmatrans SSG SANAQ® for Rapid Tablet Disintegration

When it comes to developing high-quality pharmaceutical tablets, excipients pay a crucial role in ensuring optimal performance, consistency and bioavailability. Among the variety of excipients used, superdisintegrants are key to achieving fast and efficient tablet disintegration, ensuring that the active pharmaceutical ingredient (API) is released at the right time and in the right place within the body.

Pharmatrans offers tablet manufacturers SSG SANAQ® Sodium Starch Glycolate as an added value ‘superdisintegrant’ pharmaceutical excipient to achieve superior tablet dissolution in oral dosage forms.

SSG SANAQ® superdisintegrant is particularly useful for tablet formulations that incorporate hydrophobic lubricants that often hamper rapid disintegration due to hydrophobic film covering the ingredient particles. Here, SSG SANAQ® guarantees rapid water absorption, with its excellent swelling properties ensuring complete disintegration of the tablet.

Renowned for their precision, consistency, and dedication to quality, Pharmatrans SANAQ®’s products have become essential to pharmaceutical companies worldwide striving to meet the highest standards in drug development.

Sodium Starch Glycolate as an Excipient

Disintegrants are substances or mixture of substances added to the drug formulations, which facilitate dispersion or breakup of tablets and contents of capsules into smaller particles for quick tablet dissolution. Superdisintegrants are substances that facilitate even more rapid disintegration, using smaller quantities of excipient.

Sodium starch glycolate (SSG) is a widely used pharmaceutical excipient in OSD formulations that demands rapid dissolution and water absorption of the API.

Starch glycolates can be derived from rice, wheat, corn, or, in the case of the Pharmatrans SSG SANAQ product, from potato starch. Chemically speaking, SSG is the sodium salt of a carboxymethylether of starch. This means that substitution and cross-linking chemical modification processes are carried out to the basic amylose and amylopectin polymers by carboxymethylation to increase hydrophilicity and reduce gel formation and solubility upon contact with water.

In this modified form, SSG can be used as an excipient in tablets and capsule fillings that absorbs water very quickly, bringing about swelling that prompts faster breaking down of the tablet matrix.

Various SSGs are available from different sources but not all SSGs are created equal as they differ in their manufacturing methods, physicochemical properties and quality attributes. The compaction and rapid disintegration properties of starches are known to depend on source materials and on the chemical process used to transform the basic potato, rice, or corn starch.

SSG SANAQ® Features

Superdisintegrant Properties: SSG SANAQ® is engineered for fast and efficient tablet disintegration, which is crucial for drugs that require rapid onset of action. As a superdisintegrant, it swells significantly upon contact with water, breaking apart the tablet and releasing the API quickly for absorption. This property is especially beneficial for immediate-release formulations, where rapid drug release is desired.

Enhanced Bioavailability: By promoting faster disintegration, SSG SANAQ® helps improve the dissolution rate of poorly soluble drugs, thus enhancing bioavailability. This makes it an ideal excipient for formulations that include APIs with low water solubility or drugs where faster therapeutic action is required.

Versatile Applications: SSG SANAQ® can be used across various dosage forms, including tablets, capsules, and granules. It is compatible with both wet and dry granulation processes as well as direct compression, allowing flexibility in manufacturing methods.

Uniform Particle Size and Consistency: Pharmatrans SANAQ ensures that SSG SANAQ® is manufactured with consistent particle size and quality. This uniformity helps maintain product stability, improves flow properties in the manufacturing process, and ensures that the tablets disintegrate reliably within specified timeframes.

Regulatory Compliance and Quality Standards: SSG SANAQ® meets stringent regulatory requirements. SSG SANAQ® is listed as starch derivative whose chemical and physical identities meet the latest standards of international pharmacopoeias such as Ph. Eur., USP-NF, and BP. Pharmatrans SANAQ AG’s commitment to quality and compliance ensures that SSG SANAQ® is manufactured under Good Manufacturing Practice (GMP) guidelines, making it suitable for use in pharmaceutical formulations globally.

These advantages combine to offer pharma manufacturers faster and easier product development in tablet formulation, enhanced production yields with new high-speed direct compression, as well as continuous manufacturing possibilities.

Ready to Accelerate Your Tablet Formulations?

As the demand for high-performance excipients grows, products like SSG SANAQ® provide essential functionality that directly impacts the efficacy and reliability of pharmaceutical products.

SSG SANAQ® is your solution for cutting-edge superdisintegrants and excipients that transform the way medications are experienced.

Discover how Pharmatrans SANAQ® can elevate your formulations. Get in touch with our team today to learn more about our products and start creating the next generation of high-performance, rapidly disintegrating tablets.

Resources

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