In Vitro Skin Irritation Test

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In Vitro Skin Irritation Test

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Example for a corrosive amine classified false-negative in an in vitro skin irritation test

Lehmeier, Dagmar, Dr. Hofman-Huether, Hana, Dr. Kreiling, Reinhard


ABSTRACT

Considering animal welfare concerns alternative in vitro test methods for skin corrosion/irritation testing have been validated and accepted as full replacement tests by applying a tiered testing strategy (see Annex to OECD 404, 2002). We examined one amine derivative to determine best suitable test methods for classification of several substances of the same chemical class using the following methods in consecutive steps:

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In Vitro Skin Irritation Test


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