Enabling Sustainable Large-Scale SPPS Through Process Innovations

Delivery of polypeptides in multi-kilogram quantities within tight timescales is extremely challenging, especially when coupled with a desire to minimize environmental and economic impact. This case study explores how CPC Scientific’s advanced process improvements during synthesis, cleavage, and final purification of solid-phase peptide synthesis (SPPS) have enabled multi-kilogram delivery of a pharmaceutically-relevant decapeptide within a short timescale. These innovative modifications reduced environmental footprint and delivered substantial cost savings for the client, ultimately enhancing market competitiveness of the product.