CBDepot Cannabis sativa extracts for cosmetics

CBDepot now offers a complete range of cannabidiol (CBD) and cannabigerol (CBG) Cannabis sativa Leaf Extracts for use in cosmetics.

CBDepot also offers Isolated and Synthesized trans-Cannabidiol preparations for cosmetic applications.

Cannabis leaf extract portfolio

There are four cannabis leaf extract products in the CBDepot portfolio, all highly suitable for cosmetics use.

• Hemp leaf-derived Cannabidiol: Presented in powder form, this HACCP-certified isolated trans-Cannabidiol, isolated extract is suitable for professional use in e-liquids and foods, as well as cosmetics. It is derived from Cannabis sativa L. leaves of any cultivar listed in the EU Plant variety database, with purity of ≧98%. The powder can be dissolved in alcohols, alkanes, aromatic hydrocarbon, chlorinated solvents, or polar aprotic solvents. In the EU Cosmetics Ingredient Database, this isolated CBD extract is indicated as an antioxidant or antiseborrhoeic, for skin conditioning and skin protection.
• Synthesized Cannabidiol: This HACCP-certified powder preparation has similar specification and applications to isolated trans-CBD but is derived from chemical synthesis, rather than cannabis leaves.
• Cannabis sativa Leaf Extract – CBD type: This amber and viscous cannabidiol intensive oil is derived from Cannabis sativa L. leaves of cultivars listed in the EU Plant variety database with earthy smell and taste with notes of pine and pepper. It solidifies below 50°C and liquifies above that temperature. This preparation contains naturally present decarboxylated phytocannabinoids (50% w/w), terpenes (0.5% w/w) and waxes (2% w/w), all within hemp seed oil for standardization of content. It dissolves in a similar range of solvents to the powdered products. In the EU Cosmetics Ingredients Database, Cannabis leaf extract CBT oil is indicated as useful as an emollient and for skin conditioning.
• Cannabis Sativa Leaf Extract – CBG type: : With a similar appearance, flavors and specifications to the CBD oil, this leaf extract oil is rich in cannabigerol (CBG), which is also indicated for cosmetics use an emollient and as a skin conditioner.

All products are included in the EU CosIng guidance database, which has been recently updated to accommodate extracts derived from hemp leaves without restriction 306 as per Annex II to Regulation (EC) No 1223/2009.

All CBDepot cosmetic ingredients are regulatory complaint as tested in an accredited 3rd party lab under Standard Operating Procedure applied for cosmetics, with THC values below detectable levels at under 5 mg/kg (<0.0005%). Even lower THC versions with <1mg/kg (<0.0001%) THC areavailable on request.

Cannabinoid cosmetics applications

Use of cannabinoid extracts in cosmetics has been increasing rapidly over the past two years, with a wealth of recently published scientific studies on potential therapeutic and other benefits. These include:

• Cannabidiol exerting sebostatic and anti-inflammatory effects on human sebocytes: Due to combined lipostatic, antiproliferative, and anti-inflammatory effects. CBD is thus indicated as having potential as a therapeutic agent for the treatment of acne vulgaris. (Oláh et al. 2017)
• Cannabinoids for novel control of human keratin expression: Cannabinoid receptor 1-mediated signaling appears to down-regulate the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ, suggesting that cannabinoids and their receptors constitute a novel, clinically relevant control element of human K6 and K16 expression. (Ramot et al., 2016)
• Epigenetic control of skin differentiation genes by phytocannabinoids: Study findings show that the phytocannabinoids cannabidiol and cannabigerol are transcriptional repressors that can control cell proliferation and differentiation with potential to become lead compounds for the development of novel therapeutics for skin diseases. (Pucci et al., 2016)
• This indicates that they (especially cannabidiol) have the potential to be lead compounds for the development of novel therapeutics for skin diseases.
• The endocannabinoid system of the skin in health and disease: Endocannabinoids are linked with a delicate balance within human physiology whose disruption might facilitate the development of multiple pathological conditions and skin diseases, such as acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer. (Oláh et. al., 2016)
• Cannabinoids inhibit human keratinocyte proliferation: Study indicates that through a non-CB1/CB2 mechanism, cannabinoids inhibit keratinocyte proliferation and have a potential therapeutic value in the treatment of psoriasis. (Wilkinson and Williamson, 2016)
• Topical cannabinoid agonists for treating chronic pruritus: Topical cannabinoid agonists represent a new effective and well-tolerated therapy for refractory itching of various origins. Creams with a higher concentration may be even more effective with broader indications. (Ständer et al. 2016)

Resources

Click on Skin Conditions for research study abstracts.