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    Brevetti Angela to present latest prefilled syringe developments at BFS IOA Asia/Pacific

    news-releasesBrevetti Angela Srl
    November 18th 2022

    Vicenza, Italy: – Leading manufacturer of high technology pharma packaging machinery, Brevetti Angela Srl, will round out its 2022 series of Blow-Fill-Seal International Operators Association appearances at December’s BFS IOA Asia/Pacific meeting in Singapore.

    Once again, Brevetti Angela will share latest developments in its journey to develop the innovative O-Flow prefilled syringe produced by sister company 3CK.

    Drawing on experience

    As a leading member of the BFS IOA, Brevetti Angela has co-sponsored all the association’s events for more than a decade. As usual, it will contribute to the science and technology conference agenda with Sales & Marketing Director Eng. Rajeev Kabbur presenting ‘Update on new generation of prefilled syringes‘ on the morning of the first day of the conference (December 1, 1055 hrs).

    Mr. Kabbur’s presentation will trace the story of Brevetti Angela’s development of prefilled syringes manufactured on BFS machines. He will go through five product generations, starting with a squeezable, single-use container; this was followed by a two-component syringe with embedded needle, and then by a more standard-looking plunger device with volumes ranging from 0.5ml to 20ml. Such long research in developing the prefilled syringes on BFS started at the end of the Nineties, and gradually showed and solved the faults in the previous devices, until today Brevetti Angela was able to partner with 3CK to present the 5th generation O-Flow.

    Fifth generation advantages

    Mr. Kabbur will explain how the 5th Gen 3CK O-Flow solution overcomes the key issue that has plagued prefilled syringes; the use of silicone oil to ease plunger movement that can also form submicron- and micron-size oil droplets when syringe is agitated, potentially leading to early- and late-stage immune responses.

    The O-Flow is silicone-free and yet completely eliminates break loose force, making plunger movement much easier and more controlled. The new syringes also use materials with lower protein adsorption properties to suppress protein aggregation.

    They are also compliance-friendly with large printable surfaces available for laser-printed markings and product related information and being formable from a wide range of materials including PP, COC, COP, Multilayer, TPE, TPV, and Bromobutyle that can both reduce oxygen and moisture transmission and also help reduce extractables and leachables.

    Towards 6th Gen prefilled syringe

    “BFS IOA is one of the most important associations in our world, as the specific association for Blow Fill Seal manufacturing. We are one of the top players in the world on BFS so it is crucial for us to be involved. We always look forward to attending BFS IOA meetings to present our latest innovations and share knowledge about current market trends and demands,” said Mr. Kabbur.

    “This year we are discussing the latest developments in our production of prefilled syringes using BFS technology, including our current research on a 6th generation device that will incorporate all our learnings to date”, Mr. Kabbur added.

    About Brevetti Angela

    Brevetti Angela Srl is one of the world’s leading manufacturers of pharma primary packaging machinery, specializing in production of Blow Fill Seal (BFS) machinery for the aseptic packing of liquids in purpose formed plastic bottles, vials and parenteral forms. Brevetti Angela platforms are ideally suited to aseptic filling of pharmaceutical solutions and can also be applied to food & beverages, cosmetics or cyanoacrylates filling.

    Founded by Francesco Consolaro in 1977, the company remains based in Arzignano, in the province of Vicenza in northeastern Italy. Over more than four decades, Brevetti Angela has been guided by a vision of following a path of continuous innovation based on ensuring customer satisfaction and quality of finished product, with a mission to provide primary packaging solutions that are flexible, versatile and also reliable and easy to maintain.

    The company is particularly known for its range of advanced and patented SYFPAC® BFS machines designed and engineered to achieve the highest quality aseptic packaging of sterile pharmaceutical fluids for small volume vials, bottles, and pre-filled syringes.

    One of the key enablers for very high quality at Brevetti Angela is its emphasis on keeping all vital processes ‘in house’ at Arzignano where all facilities meet CE standards and since 2008 have been certificated to ISO 9001:2008 quality standards.

    About BFS IOA Asia/Pacific Meeting 2022

    The Pharmaceutical Blow-Fill-Seal International Operators Association (BFS IOA) is an international industry association for pharmaceutical and associated companies with direct or indirect involvement with Blow-Fill-Seal (BFS) manufacturing. BFS IOA is a non-profit organization financed by subscription of more than 60 member companies worldwide and by sponsorships from the industry.

    The association’s Asia/Pacific meeting for 2022 is a two-day event opening December 1 at the Paradox Merchant Court at Singapore’s Clarke Quay.

    The event will include presentations from Brevetti Angela and other leading manufacturers of BFS technology, including prefillable syringes, cool BFS,  sustainable BFS Bormed solutions,  disposables, container closure integrity testing (CCIT) solutions for BFS containers, and  automatic visual inspection of BFS container blocks. The meeting will also feature workshops on EU Annex 1 regulations and compliance and Defect Classification.

    The event is organised by the BFS International Operators Association with further information at:–Singapore


    Click on O-Flow: The next generation of prefilled and prefillable syringes for further information.
    Click on 3CK Medical Devices to view video.


    Learn all about Blow Fill Seal (BFS) technology for your aseptic packaging needs

    Brevetti Angela to present latest prefilled syringe developments at BFS IOA Asia/Pacific
    Brevetti Angela to present latest prefilled syringe developments at BFS IOA Asia/Pacific

    The 3CK O-Flow plastic prefilled syringe concept offers multiple innovations and benefits.

    Brevetti Angela to present latest prefilled syringe developments at BFS IOA Asia/Pacific

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