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Pierre Fabre Supercritical to present ibuprofen breakthrough at AAPS conference

news-releasesPierre Fabre Médicament: Supercritical Fluids Division
October 30th 2014

Gaillac, France: – Pierre Fabre Laboratories supercritical carbon dioxide specialists (“Supercritical Fluids Division”), will post details of a new process that leads to significant taste masking result on production of the western world’s most popular painkiller, ibuprofen.

Dr. Hubert Lochard, Project Manager in the Supercritical Fluids Unit, will present a poster at the upcoming American Association of Pharmaceutical Scientists (AAPS) annual meeting in California.

Dr. Lochard’s poster on “Production and characterization of Ibuprofen Coated by Supercritical CO2 Process” will show how the patented processes: Formulcoat® (coating process for taste masking) can lead to create a GMP compliant technology for pre-formulating ibuprofen API.

Supercritical benefits

“My poster will show how this new platform can deliver significant formulation benefits, not least the environmental savings in using pressurized CO2 as the extractive medium,” said Dr. Lochard.

SuperCritical Fluids Division will also be an exhibitor at the AAPS conference. Visitors to the Supercritical stand at Booth 3730 will be able to see details of the division’s four current technologies; Cyclodextrin complexation in supercritical fluid medium (Formulplex®), solid dispersion using supercritical fluids (Formuldisp®), coating using supercritical fluids (Formulcoat ®) and using Crystallization to enhance dissolution rate by increasing the surface specific area of an API.

The team will also be able to share latest developments on other innovations under development, including extraction, purification, and medical device cleaning.

About Supercritical Fluids

Supercritical Fluids Division (SFD) is a specialized subsidiary of Pierre Fabre Médicament, France’s second largest independent pharmaceutical laboratory, focusing on ethical drugs, health products and dermocosmetic products.

The division has developed specialized expertise in supercritical fluids technology for pharmaceutical applications, in particular in Drug Delivery Systems (DDS).

In particular, the division is responsible for the development and application of Pierre Fabre Medicament’s Formulplex® process that uses Supercritical CO2 as a reactive medium to increase the solubility of pharmaceutical active ingredients, along with proprietary technologies. These include Formulcoat® an innovative process that uses expansion of pressurized CO2 combined with lipidic agent to create a uniform and homogeneous layer without agglomeration; the Formuldisp® batch process that uses supercritical fluids to produce stable solid dispersion and Cristallisation, using supercritical CO2 to enhance dissolution rate by increasing the surface specific area of an API.

SFD offers services in the fields of pharmaceutical development, life cycle management and outsourcing in a cGMP environment that can be used by a range of life sciences companies, from start-ups to multinationals. These services include process development and optimization, production of clinical and commercial batches, technology transfer and analytical development.

SFD’s FDA-approved production plant in Gaillac, near Toulouse, in the Tarn Departement of France, operates two production workshops, each of 150m2; one dedicated to development and the other to production. These facilities can work with toxic molecules and at various scales, from grams to several tens of kilograms.

The Supercritical Fluids Division is ICHQ7A, GMP and BPF (Bonnes Pratiques de Fabrication) compliant. Since 2005, French health authorities have accepted it as a Recognized Pharmaceutical Establishment.

About AAPS

The 2014 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition will be held from November 2 to November 6 at the San Diego Convention Center in California.

The AAPS Annual Meeting provides a dynamic international forum for the exchange of knowledge among scientists to enhance their contributions to public health. The meeting provides a prominent annual opportunity for scientists from various disciplines to meet their peers; discuss the latest research topics presented at contributed paper poster sessions; discuss projects with current and new suppliers.

The 2014 scientific program will use workshops to focus on a very wide range of topics, with more than 15 workshops scheduled over the five-day event.

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