Multiple myeloma model

Multiple myeloma remains incurable, with only 40 percent of diagnosed patients still alive five years after diagnosis. There is also a recognized unmet need in the treatment of relapsed and refractory multiple myeloma.

Pharmatest offers a systemic mouse model of multiple myeloma that closely mimics the clinical conditions of myeloma bone disease in patients.

Description

The model responds to clinically relevant treatment (bortezomib) and is suitable for testing the efficacy of drug compounds against multiple myeloma, and especially active myeloma, which is always characterized by the presence of osteolytic lesions.

Pharmatest’s disseminated multiple myeloma model involves inoculation of mouse multiple myeloma cells into the tail vein of immunocompetent mice.

The animals are monitored by measuring lesion area by radiography and the amount of paraprotein IgG2b in serum, which will reveal the progression of the disease.

Tumor area, bone area and osteoclast number can be determined by histology to reveal detailed information about effects on bone metastases.

Resources

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Supplier Information
Supplier: Pharmatest Services Ltd
Address: Itäinen Pitkäkatu 4 C, 5th floor, 20520 Turku, Finland
Tel: +358 2 278 4700
Fax: +358 2 278 4710
Website: www.pharmatest.com