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    Biosynth e-book: Nucleosides, Nucleotides & Nucleic Acids Toolbox Pt. 1

    November 8th 2023

    Biosynth has released the first of its new series of eBook digital handbooks that provide a thorough guide to small molecule nucleosides and nucleotides, their analogs, and oligo- and polymers.

    The two-part Nucleosides, Nucleotides & Nucleic Acids Toolbox series is designed to serve as a primer and summary for those interested in this class of molecules that are playing an ever more important part in the next generation of therapies and drug development.

    The Part 1 eBook ‘Nucleosides and Nucleotides, Chemistry, Structures, Modifications & Analysis provides a guide on their basic characteristics, chemical structures, development history, as well as some of the important  applications in the life and medical sciences.

    The guide is authored by Dr. Hansjoerg Streicher, who is a specialist consultant in organic synthesis, glycoscience, and carbohydrate chemistry. He is also a Senior Scientific Advisor to Biosynth, working with its project teams to provide expert advice on synthetic approaches and intellectual property consideration.

    Rather than being a comprehensive science discussion,  these books aim to bring together the most important concepts, stories, developments and applications to provide greater understanding of the commercial and drug development potential of nucleotides.

    This first handbook focuses on the structure, analysis, and synthesis aspects while Part 2 will  focus on the story of their oligomers including DNA and RNA, our molecules of inheritance. This creates a pair of complementary handbooks telling the complete story across the building blocks to complex oligomers.

    The first guide is structured in five sections:

    • Section 1 defines the basic chemical structures and nomenclature terms of nucleosides and nucleotides.
    • Section 2 explains more about their chemistry and analytics with particular reference to notable research milestones, the N–Glycosylation of Ribose, and the applications of spectroscopy and chromatography in characterizing oligomer.
    • Section 3 examines how nucleosides become modified; both by natural processes and in the laboratory in drug development; to produce antivirals, anti-cancer drugs, antibiotics, and antifungal treatments.
    • Section 4 expands on the generation of nucleotides and ylic acids as ester modification of nucleosides using phosphoric acids, and the various classed formed such as Nucleoside 5’-Mono-, Di- and Triphosphates. It also discusses the technologies, challenges and latest approaches to producing nucleotides as (Pro-) Drugs.

    Extensive References provide a guide to in-depth further reading.

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