Address: Akzo Nobel Pulp and Performance Chemicals AB, Separation Products, SE-445 80 Bohus, Sweden
Tel: +46 31 58 70 00
Fax: +46 31 58 77 27

Kromasil by Akzonobel

The Kromasil® product line is developed and manufactured by the Sweden-based Separation Products group of AkzoNobel Pulp and Performance Chemicals, one of the world’s leading providers of specialty chemicals.

The Kromasil team’s mission is to develop outstanding solutions for high-performance liquid chromatography (HPLC), ultra high-performance liquid chromatography (UHPLC) and supercritical fluid chromatography (SFC), to improve efficiency and decrease separation costs.

The introduction of Kromasil perfectly spherical silica-based packing materials has greatly improved the effectiveness of liquid chromatography with its unique combination of high pore volume and surface area, together with a very high mechanical stability that remain unmatched by any other chromatography packing media on the market.

Applications

Kromasil packings and columns have been used over the years for demanding chromatographic separations all over the world ranging from small synthetic molecules, up to peptides and proteins. Popular industrial applications include:

  • Peptides for diabetes treatment:Insulin and its analogues
  • Organic compounds for obesity treatment: Orlistat
  • Immunodepressant macrolides: Tacrolimus
  • Proteins as large as 150 kDa, like Interferon α

In analytical HPLC, Kromasil can be used for the separation and analysis of a wide range of molecules, from the smallest aromatics, amino acids, pesticides, drugs like antibiotics and steroids, vitamins to larger molecules like peptides such as oxytocin or insulin and their analogues.

Products

Kromasil is a fully back-integrated manufacturer of totally spherical silica particles for high performance chromatography usage.

All Kromasil products are manufactured in-house. It stands for the silica matrix as well as the subsequent derivatization steps. Separation Products control the whole manufacturing process, including packing of columns, to ensure extremely high batch-to-batch or column-to-column reproducibility.

These products are available as bare silica as well as with various surface modifications for normal phase, reversed phase and chiral applications.

There are three main categoriesof Kromasil products:

Kromasil Classic

This is a range of premium silica-based chromatography packings developed for analytical up to process-scale applications. Kromasil Classic products are available in pore sizes from 60Å, to 300Å, and in particles sizes from 1.8 µm up to 25 µm. Kromasil Classic silica packings are designed to meet the highest demand in UHPLC, HPLC, SFC, and SMB, being optimized for high surface area, mechanical strength, chemical stability and purity, optimized surface properties and well-defined pore structure. Along with the bare silica, Kromasil Classic is available with various surface modifications like alkyls, amino, diol, cyano and phenyls.

Kromasil Eternity

Kromasil Eternity and its extension EternityXT are platforms based on Separation Products’ state-of–the art grafting technology, to be used for reversed-phase separations that could pose harsh conditions. Based on more than 25 years of stationary manufacturing and packing expertise, the Eternity products represent innovative media for achieving separation and purification of compounds under harsh reversed phase HPLC and UHPLC conditions. The silica/organosilane surface of Kromasil Eternity products enables a wider temperature and ph range. In fact, EternityXT C18 has an operating window up to pH 12, ensuring greater chemical stability, and consequently longer column lifetime, for regular silica-based HPLC phases. Eternity and EternityXT are available with alkyls and phenyl hexyl surface modifications.

Kromasil Chiral

Kromasil AmyCoat and CelluCoat packings are designed to stretch the limits for analytical and industrial chiral chromatography. These chiral products are based on an in-house developed Kromasil silica matrix with enhanced porosity that can be coated with functionalized amylose or cellulose selectors. Kromasil AmyCoat and Kromasil CelluCoat offer high resolution and excellent selectivity when switching between compatible mobile phases. Benefits include faster results with smaller particles and shorter equilibration times, stable performance and less restrictive pressure limits. With Kromasil AmyCoat RP and CelluCoat RP columns, reversed phase applications can be run with maximum efficiency. Kromasil Chiral phases are also adequate for separations under SFC conditions.

Support services

Separation Products can provide a wide array of technical support services. The Kromasil team of chemistry specialists and chemical engineers is configured to be customer facing and can provide direct answers to a huge variety of customer queries and problems.

Resources include:

  • Process optimization for the best separations at lowest cost
  • Assistance with DAC column packing with Kromasil
  • Help with troubleshooting
  • Workshops and seminars
  • Web based resources like FAQ, downloadable publications and tools

The handy KromaSwitch tool can identify the matching Kromasil product to replace a previous brand of packing material.

Background & structure

Separation Products is a department within AkzoNobel Pulp and Performance Chemicals, a global business unit with 2 400 employees in 35 countries, within AkzoNobel, one of the world's largest chemical groups, with about 50 000 employees in more than 80 countries.

Kromasil products are available direct from Separation Products or via one of the company’s partners in a worldwide distributor network that includes subsidiaries in China, India and the USA.

To learn more about Kromasil products and services and how they can assist your business, please contact the supplier directly.



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