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Peptide Specialty Laboratories GmbH
Peptide Specialty Laboratories GmbH (PSL) specializes in the synthesis of custom peptides, modified peptides as peptidomimetics and tailor made peptide-specific antibodies.
PSL develops and produces a range of customized synthetic peptides, bio conjugates and peptide-specific antibodies for research institutes, universities and pharma companies. The Heidelberg-based laboratory synthesizes peptides as substrates for enzymes or perform modifications of peptides with specific properties that cannot be created naturally, mainly for use in drug research and also to produce complete immunization services.
Products & Services
PSL provides a wide range of ‘Premium Peptides for Excellent Results’, including:
- Custom synthesized peptides in 1 mg to 1 g quantities
- Peptide conjugates
- Peptide specific antisera (Rabbit, guinea pig, mouse, etc.)
- Cyclic peptides
- Acetylated, myristoylated, palmitoylated, phosphorylated peptides
- Peptide-protein bioconjugates (KLH, BSA, OVA, Biotin, etc.
- Fluorescent dyes
PSL also offers a range of services, including complete immunization services, affinity purification of antibodies and all-in-one packages.
Because selection of optimal starting materials is critical to the success of a research project, PSL also supports its clients with a professional advice service to put projects on solid foundations.
PSL can develop customized peptides that are individualized to customer requirements. These peptides can vary in length up to 30 amino acids and, in special cases up to 100 amino acids.
These peptides can be further modified with modified amino acids (methylated, phosphorylated, sugar-modified, D-amino acids, stable isotopes etc.) through acetylation, placing amide at C-terminus and using peptide-protein conjugates (KLH, OVA, BSA, Diphtheria toxoid).
PSL can also incorporate Biotinylation, fluorescence marking, peptide-fatty acid conjugates peptide-chelator conjugates such as DTPA, DOTA or NOTA, peptide-PEG conjugates, cyclic peptides (disulphide, “Head to Tail”) or branched peptides.
Structure and history:
Peptide Specialty Laboratories was originally founded in September 2000 as a spin-off of the German Cancer Research Center (DKFZ), where co-founder Dr. Hans-Richard Rackwitz developed a world-leading body of knowledge and experience in peptide synthesis and antibody production, building on previous work at the renowned Scripps Research Institute in La Jolla, California. Since 2003, the company has been headquartered in the Technology Park outside the ancient university city of Heidelberg.
In 2016, PSL became a subsidiary of Bioassay GmbH, also located at Heidelberg Technology Park. In the beginning of 2017, Dr. Adrian Glas joined PSL as Head of Laboratory contributing with his knowledge in peptide synthesis and the stabilization of peptide secondary structures.
Quality and Regulatory
Peptide Specialty Laboratory’s quality standards are underpinned by many years of successful project experience in all kind of peptide related topics.
All PSL peptides are purified to 90 to 95% purity using high-performance liquid chromatography (HPLC) and precisely analyzed using the Matrix-Assisted Laser Desorption-Ionization mass spectrometric (MALDI-MS).
The absolute quality of PSL synthesized peptides is further underpinned by the experience of its staff and the use of leading-edge technical equipment, such as CEM Liberty Blue peptide synthesizer or the continuous flow peptide synthesizers developed by EMBL (European Molecular Biology Laboratory) in Heidelberg.
The company is committed to meeting ISO standards and is progressing towards full ISO 9001:2015 accreditation.