Sofrigam

Plasibox® – rigid, robust and reusable insulated packaging solution


Plasibox® – rigid, robust and reusable insulated packaging solution


Sofrigam 150x54

Products & Services | Sofrigam S.A

Overview

Plasibox® from Sofrigam is a range of rigid, robust and reusable iceboxes to transport chilled or frozen products. With excellent integral insulation, Plasibox® will maintain products at cold chain temperatures for two days.

Features

The Plasibox® is constructed of rigid high density polyurethane panels with special insulation coating, a rigid plastic case and “Rigid Snowgam” eutectic cooling plates.

The box can be cleaned with alcohol, chlorinated water or any other disinfectant.

With its excellent overall coefficient of heat transfer K and its ability to withstand mechanical impact, the Plasibox® safeguards medicines or other temperature sensitive products from mechanical shock and temperature excursions in transit.

Used with cooling gel packs, the Plasibox® can maintain pharmaceutical, biotechnological or food products at stable low cold chain temperatures as low as –5°C and to maintain goods at below 8°C for up to 48 hours.

Side handles make the Plasibox® easy to handle. The box lid can also be sealed with an optional tamper proofing system.

Applications

The Plasibox® insulated box solution is particularly useful forshort-term transportation (maximum of 48 hours) where robust protection, ease of handling and reusability are useful features.

Plasibox® was originally developed for an Eastern European warehouse/distributor that needed a reusable temperature-controlled solution in order to deliver temperature-controlled drugs between +2 and +8°C to client pharmacies, hospitals, and clinics, using non-refrigerated vehicles in delivery cycles lasting at least 24 hours and carried out in average ambient temperatures of +25°C.

In order to make distribution economically sustainable, the client needed to recover the cooling box after each delivery and store for the next cycle.

Testing and qualification

Following initial design and development, the Plasibox® system was tested and qualified by the Ater Metrologie temperature testing lab, an ISTA certified environmental testing laboratory. The packaging was tested by simulating the real climatic conditions to ensure that it could keep temperature-controlled products within approved temperature limits throughout the entire delivery cycle.

Test results showed Plasibox® was able to sustain internal temperatures below 8°C for 35 hours at an ambient temperature of 25°C.

Plasibox-30L Test 09-634

Plasibox-30L Test 09-634

Resources

Click on Plasibox® – rigid, robust and reusable insulated packaging solution for other information.
Click on Sofrigam SA to contact the company directly.


Supplier Information
Supplier: Sofrigam SA
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com


Sofrigam sustainable insulated packaging solutions


Sofrigam sustainable insulated packaging solutions


Sofrigam Logo

Products & Services | Sofrigam S.A

Overview

Sofrigam is placing the challenges of sustainable development at the core of its strategy. The focus is on polyurethane, a material that is ideal from both insulating and ecological aspects. Sofrigam uses polyurethane-based insulated packaging to deliver Cold Chain solutions that are more efficient, cost effective and sustainable.

Ecological advantages of polyurethane

Polyurethane is used everywhere: in construction, manufacturing, packaging and almost every other aspect of daily life. It is also the material of choice for insulated packaging in temperature-controlled logistics, making it the cornerstone of Sofrigam’s environmental policy.

Polyurethane has four key ecological advantages:

  • Energy efficiency: Polyurethane is the least energy-intensive of all the insulating materials, since its manufacture requires significantly less petroleum, with energy inputs between one third and one fifth of the specific energy consumption of thermoplastics. Combined with exceptional thermal insulation properties, this means polyurethane can produce energy economies up to 100 times greater than those consumed in manufacture. Furthermore, the service life of polyurethane is longer than that of other insulating materials.
  • Lightness and thermo-efficiency: Polyurethane is both thinner and more efficient than other types of insulating material. This reduces the volume of the insulating material required. As a result, the manufacture of insulated containers consumes less energy in transport and application, yielding significant CO2 and other energy savings.
  • Recyclability: Polyurethane can be recycled in a number of ways; in construction materials, in aggregates and as energy through incineration.
  • Sustainable sourcing: Conversion to cleaner blowing agents for polyurethane foam production has paved the way for development of bio-based renewable raw-material feedstocks. Soybean and castor oil can be used to produce natural-oil polyols.
  • (NOPs) that replace the petrochemical-derived polyol components of polyurethane. Industry sources estimate NOP-based manufacturing of polyester and polyether polyols produce 36% less global-warming emissions, 61% less non-renewable energy use, and 23% less total energy demand.

Sofrigam polyurethane-based insulation solutions

Sofrigam incorporates polyurethane-based insulation in almost all of its packaging solutions.

Bulk cold chain shipping packaging solutions use polyurethane panels and VIP liners in various formats to insulate vaccines, ophthalmic products, chemotherapy solutions and other heat sensitive products in storage and transport. These polyurethane-protected packages can maintain constant temperatures for up to 72 hours while being lighter, more compact and more thermally efficient than other materials, delivering significant savings in space, cooling energy and transport costs. Polyurethane liners are also used in Sofribag® iceboxes and Nomad delivery cool bags.

Sofrigam recycling

As part of its sustainability commitment, Sofrigam has also implemented a range of recycling solutions for polyurethane materials. These solutions include:

  • Recycling as construction insulating material: the polyurethane panels used in insulated pallet shippers are retrieved and sold on www.isolation-polyurethane-discount.fr
    Polyurethane foam 1.6 cm thick has the same thermal insulation effectiveness of a 1.34m thick concrete wall!
  • Crushing and recycling in cement works: Polyurethane panels from cooling boxes are crushed into particles that can be used as aggregate in building cement to make the resulting concrete and mortar lighter and more thermally efficient. High-polyurethane concrete is increasingly used in the construction of dams and dykes.
  • Energy recovery through incineration: waste polyurethane is incinerated in a clean manner, with pollutants being filtered out. The combustion process generates energy: the energy produced by incinerating polyurethane over a period of one year can be equivalent to the annual electricity consumption of a four person household.

Resources

Click on Sofrigam sustainable insulated packaging solutions for other information.
Click on Sofrigam SA to contact the company directly.


Supplier Information
Supplier: Sofrigam SA
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com


Revealed: razor-thin margins of protecting heat sensitive medicines


Revealed: razor-thin margins of protecting heat sensitive medicines


Sofrigam Logo

JULY 08, 2014

Press Release | Sofrigam S.A

Monchy-le-Preux , France: – Maintaining the cold chain for heat sensitive medication is a high stakes business. Any break in the temperature controlled chain, even for a minute or two, can have disastrous consequences for the patient and expose manufacturers and suppliers to major financial losses. A minor temperature excursion of a few degrees outside the limits permitted by marketing authorization can render a vaccine or medicine ineffective – even toxic.

Few organisations are more aware of these uncomfortable truths than France’s Ater Métrologie laboratory. From its base in the village of Monchy-le-Preux, south of Arras in Pas-de-Calais, the laboratory conducts thousands of tests a year to establish the margins between success and failure in temperature-controlled packaging and cooling systems.

Laboratory director David Stienne explains that these margins can be razor-thin, recounting results on a recent test to find out how long unprotected products can maintain permitted temperature if cooling fails during storage or transport.

“We carried out a test on a simulation vaccine. The active product was replaced by water, but the packaging was strictly identical to the vaccine on the market: an outer cardboard box and a heat moulded plastic blister enclosing the vaccine,” Stienne explained.

Shock results

After fitting temperature sensors on the outer box and close to the product itself, researchers placed the whole package in a professional cooling cabinet and chilled it to +3°C for five hours. Then the package was taken out of the cabinet and exposed to room temperature of around 21°C while technicians monitored readings from the sensors. The results were shocking.

“The packaging exceeded the required +8°C temperature after only three minutes of exposure,” said Stienne.

“It took only one minute more for the ‘vaccine’ inside to exceed permitted temperature, also,” he added.

“So we were able to show that the temperature rise was very fast even after a prolonged cooling period. The implications are clear: that heat-sensitive pharmaceutical products must have effective and highly portable insulation packaging. Otherwise, there is a window of only a few minutes from being removed from the cool chain during which the product can be safely administered,” said Stienne.

Widening the window

Working in partnership with Ater Métrologie, French-based cold chain logistics expert Sofrigam constantly seeks to widen that window by developing packaging and temperature stabilization technologies that can accompany heat sensitive products ever further along the chain and down the ‘last mile ‘ to the end-user.

Sofrigam’s objectives are to help pharmaceutical laboratories, producers, health professionals and patients in mitigating the risks and guaranteeing the safety, quality and effectiveness of heat products.

The range of technologies and packaging solutions that are now available can be seen in one of the most important heat-sensitive products of all, insulin.

The Insulin dilemma

The imperative to maintain insulin at between +2°C and +8°C is a life-or-death issue for more than 350 million diabetics worldwide. For decades, one of the most important questions in medicine was how to maintain this vital cold chain from insulin production laboratory all the way into the patient’s home.

“Since the mid-1980s, companies like ours have been working very hard to pioneer new insulated packaging solutions and adapt them to insulin transport, extending all the way to dispensing chemists and even end-users to avoid any breaks in the cold chain,” said Sofrigam Marketing Director, Laetitia Perche.

“The stakes are high, as it only needs two minutes at room temperature for a heat sensitive treatment to exceed safe temperature without it necessarily being detectable on the product. Insulated or refrigerated packaging solutions are essential to conserve the treatment properties of insulin. Health professionals must therefore take care to protect heat sensitive medication at all levels of the cold chain, especially when delivering the medication to the patient,” she added.

Innovative solutions

One of Sofrigam’s most recent innovations is the Nomad cooling packaging line, purpose-designed for the transport of heat sensitive pharmaceutical products such as insulin by healthcare workers and patients. The Nomad line includes a refrigerated soft pouch to transport vaccines from dispensary to the patients’ home, preserving insulin and other heat-sensitive products for up to two hours at below +8°C, even without any cooling media.

Sofrigam has also developed new types of case to transport small batches of heat-sensitive medicines over “last mile” links in the cold chain, including Plasibox®, a rigid plastic icebox that is practical, easy to use, and robust and Textibox®, a rigid textile icebox that combines the thermal performances of an icebox with the ease of handling of a flexible insulated bag.

These insulated packaging solutions can be used with or without added cold sources such as cooling gel packs.

“The Nomad packaging range allows patients to transport their insulin in a pouch or in a vaccine cooler bag, from the dispensing chemist to their home, or when they are travelling,” Perche explained.

“Insulin can be kept for up to two hours using the Slim pouch, and up to 16 hours using the Thermotrousse cooling bag. Adding gel packs inside the packaging may be required, especially if the insulin has already been prepared in an injector pen, or in very hot weather.”

“Freezing insulin should, however, be avoided,” Perche cautioned. “To achieve this, the patient can keep the gel pack in the refrigerator before use. Flat gel packs can be placed inside heat insulated pouches if they are not in direct contact with the product.”

About Sofrigam

French company, Sofrigam S.A. designs and manufactures cool chain shipping solutions and insulated boxes for the pharmaceutical and biotechnology industries as well as for distribution and logistics companies.

The company was founded in 1979 by an industrial pharmacist and initially developed eutectic painkillers before specializing in the design and manufacture of insulated and refrigerated packaging, including pre-qualified insulated shipping solutions. The company is headquartered in Ile-de-France with a production site at Arras.

Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customized services designed to achieve secure, cost effective and ecological cold chain logistics.

Sofrigam has become one of Europe’s leading cold chain specialists, sharing its expertise via seminars, publications and R&D collaborations. It also offers customized products and services designed to achieve cold logistics that are secure, cost-effective and comprehensively compliant.

Sofrigam partners with Ater Métrologie, a French-based ISTA and ISO 9001 certified laboratory that specializes in testing, validating and pre-qualifying temperature-controlled packaging and cooling systems. The laboratory carries out some 2,000 tests each year.

Media Contact

Laetitia Perche, Marketing Director, Sofrigam SA
Tel: +33 (0) 1 46 69 85 43
Email: marketing@sofrigam.com

Reliable and practical solutions

Reliable and practical solutions to guarantee protection of medicines

Nomad Refrigerating Packaging

Nomad Refrigerating Packaging is ideal for transporting sensitive pharmaceutical products

Resources

Click on Revealed: razor-thin margins of protecting heat sensitive medicines for other information.
Click on Sofrigam SA to contact the company directly.


Supplier Information
Supplier: Sofrigam SA
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com


Thermo-Sensitive Pharmaceuticals Form Hottest Growth Sector of Global Medicines Market

Press Release – Sofrigam S.A
Thermo-Sensitive Pharmaceuticals Form Hottest Growth Sector of Global Medicines Market

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Thermo-Sensitive Pharmaceuticals Form Hottest Growth Sector of Global Medicines Market
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

JANUARY 29, 2014

Thermo-Sensitive Pharmaceuticals Form Hottest Growth Sector of Global Medicines Market

Cedex, France: – The medicine market is enjoying strong growth, led by increased sales of a new generation of heat-sensitive products whose medicinal properties must be preserved with temperature control.

The trend is confirmed by figures just released by the French-based French cold chain shipping specialist Sofrigam S.A., which is a global leader in temperature-controlled logistics.

Sofrigam has collated figures that indicate the worldwide market of thermo-sensitive pharmaceuticals is now set to pass one billion dollars during 2014, a near 20 per cent increase since 2012, when it was valued at $880m and a 400 per cent increase over the past decade.

Sofrigam research also reveals:
• The main consumers of thermally sensitive medicines and biopharmaceuticals are North America and Europe, which together account for more than 60 per cent of the global market.
• The United States is the single greatest consumer of medicines with 38% of the global market.
• Germany and France dominate the European market, together accounting for 18% of global total for cool-chain products.

These figures can be set against the background of an overall pharmaceutical industry that has shown consistent six percent annual growth.

Sofrigam says this overall growth can be explained by the increase in the number of people suffering from diseases and health issues such as:
• Diabetes: there are 171 million diabetics in the world, and this figure should double by 2030.
• Obesity: 1.4 billion people are obese and this figure should reach 3.3 billion by 2030.
• Cancer: One woman in 20 has breast cancer, while one man in 12 has some form of cancer.
• Alzheimer’s: 18 million people suffer from Alzheimer’s, expected to reach 35 million by 2025.

Sofrigam says: “As treatments are developed for these growing illnesses, the market share of heat-sensitive medicines will also grow, for several reasons: pharmaceutical lab mergers and acquisitions, development of R&D departments, the proportion of existing patents (40 to 60 per cent) entering the public domain, strong growth of the global generic market, increasing availability for patients of targeted products developed by biotechnology.”

Cool Chain Growth
These overall trends are likely to increase the need for temperature-controlled packaging solutions for shipping heat-sensitive medicines, says Sofrigam.

“On the one hand, pharmaceutical companies must choose high-performance cold chain packaging that guarantees the medicinal properties of the products shipped, like our Frizbox® temperature-controlled pallet shipper that guarantees cold chain integrity for shipping large volumes all over the world,” according to Sofrigam Marketing Director, Laetitia Perche.

“On the other hand, it will impose new responsibilities on pharmaceutical companies to inform patients and equip them for safe transportation of their heat-sensitive medicines,” says Ms. Perche.

For these individual transport needs, Sofrigam has now developed its new Nomad® range of insulated pouches cooling bags and sachets.

About Sofrigam

French company, Sofrigam S.A. designs and manufactures cool chain shipping solutions and insulated boxes for the pharmaceutical and biotechnology industries as well as for distribution and logistics companies.

The company was founded in 1979 by an industrial pharmacist and initially developed eutectic painkillers before specializing in the design and manufacture of insulated and refrigerated packaging, including pre-qualified insulated shipping solutions. The company is headquartered in Ile-de-France with a production site at Arras.

Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customized services designed to achieve secure, cost effective and ecological cold chain logistics.

Sofrigam has become one of Europe’s leading cold chain specialists, sharing its expertise via seminars, publications and R&D collaborations. It also offers customized products and services designed to achieve cold logistics that are secure, cost-effective and comprehensively compliant.

Contact
Sofrigam S.A
Laetitia Perche, Marketing Director
Tel: +33 (0) 1 46 69 85 43
Email: marketing@sofrigam.com

For more information about temperature-controlled packaging solutions for shipping heat-sensitive medicines, please contact Sofrigam directly.

Sofrigam bringing New Thermal Science to Cool Chain Europe 2014

Press Release – Sofrigam S.A
Sofrigam bringing New Thermal Science to Cool Chain Europe 2014

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Sofrigam bringing New Thermal Science to Cool Chain Europe 2014
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

JANUARY 15, 2014

Sofrigam bringing New Thermal Science to Cool Chain Europe 2014

Luxembourg: – Gilles Labranque, Chief Executive of French cold chain shipping specialist Sofrigam S.A., will bring new insights on key scientific advances in thermal controlled logistics to this month’s Cool Chain Europe conference.

M. Labranque, who is also chairman of Sofrigam, will present a Day Two conference session on ‘Using Science to Improve Future Cold Chain Shipping Solutions’ that will explore a total engineering systems approach to temperature controlled shipments. This will include recent pioneering work on developing new computer modelling software to support a continuous improvement system, reduce time-to-market and increase container efficiency.

The session will also hear from Frédéric Kuznik, Researcher at the Lyon Thermal Sciences Centre (CETHIL), which is a Sofrigam Research Partner.

Sofrigam has become a regular exhibitor at Cool Chain Europe, it is a key event for the international logistics, pharma and biotech industries. Gilles Labranque said he had important messages to bring to the 2014 event, which will take place in Luxembourg on January 27-29.

“Each year, pharma and biotech companies ship millions of thermo-sensitive products that are very expensive and very sensitive to temperature fluctuations,” said M. Labranque.

Scientific Approach
“Not only do they need the best cold chain packaging to ensure that the products are shipped safely but they also need to be aware of the importance of finding solutions that are correctly adapted to their logistics constraints.

“The best value solution is not necessarily the one with the lowest price but the one that works best within the logistics system being used. The major costs in temperature controlled shipping are not the packaging so much as the handling time and complexity involved and the penalties of failure when temperature control fails,” M. Labranque noted.

“That is why a more scientific and engineered approach to cold chain logistics is long overdue,” the Sofrigam CEO added.

Sofrigam will exhibit the iBox, its new insulated cold chain shipping container, as well as a range of other pre-qualified insulated shipping solutions and cold chain packaging, including some previews of products scheduled for release during 2014.

It will be exhibiting at Cool Chain Europe in collaboration with its strategic partner Coolkeepers LLC, headquartered in Thomasville, Georgia, USA.

About Sofrigam
French company, Sofrigam S.A. designs and manufactures cool chain shipping solutions and insulated boxes for the pharmaceutical and biotechnology industries as well as for distribution and logistics companies.

The company was founded in 1979 by an industrial pharmacist and initially developed eutectic painkillers before specializing in the design and manufacture of insulated and refrigerated packaging, including pre-qualified insulated shipping solutions. The company is headquartered in Ile-de-France with a production site at Arras.

Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customized services designed to achieve a secure, cost effective and ecological cold chain logistics.

Sofrigam has become one of Europe’s leading cold chain specialists, sharing its expertise via seminars, publications and R&D collaborations. It also offers customised products and services designed to achieve cold logistics that are secure, cost-effective and comprehensively compliant.

About Cool Chain Europe
Cool Chain Europe is the continent’s most prestigious event targeted at providers and users of temperature-controlled logistics in general and pharmaceutical and biotech companies in particular.

The event was founded in 2001 by the Pharma IQ division of the global events company IQPC, attracting just 30 participants and three sponsors. Today, the annual event attracts more than 400 delegates, with some 50 exhibiting and sponsoring companies, making it Europe’s largest cold chain event.

Gilles Labranque will be one of more than 40 featured speakers at Cool Chain Europe 2014, which is being hosted in partnership with the Luxembourg Government at the Luxexpo Centre in the Kircher district of Luxembourg City.

A major focus of the conference will be the EU Guidelines on Good Distribution Practice (GDP) of Medicinal Products for Human Use (2013/C 68/01) that was introduced in March 2013 with full implementation over the final quarter of 2013.

Contact
Sofrigam S.A
Laetitia Perche, Marketing Director
Tel: +33 (0) 1 46 69 85 43
Email: marketing@sofrigam.com

For more information about Sofrigam bringing new thermal science to Cool Chain Europe 2014, please contact Sofrigam directly.

UN3373 Raises Stakes for Biological Substance Shipping

Press Release – Sofrigam S.A
UN3373 Raises Stakes for Biological Substance Shipping

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: UN3373 Raises Stakes for Biological Substance Shipping
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

DECEMBER 23, 2013

UN3373 Raises Stakes for Biological Substance Shipping

Rueil-Malmaison Cedex, France: – The development of UN3373 shipping regulations for Category B biological research materials has raised a new level of complexity for the many pharmaceutical laboratories, healthcare establishments, diagnostic laboratories and research centres that all transport thousands of human and animal samples each year.

French cold chain shipping specialist Sofrigam S.A. has developed an easy-to-use shipper’s guide to UN3373 and offers a series of solutions that make compliance easier than ever before for shipping by road, rail or air.

UN3373 Explained
Transport of biological samples by air must comply with International Air Transport Association (IATA) regulations while transport by road is covered by the European agreement on international road transport of hazardous goods (ADR). In either case, shipping of infectious samples must comply with the UNO-developed guidelines included in UN2814 and UN2900, while non-infections Category B materials are covered by UN3373.

To comply with UN3373, packaging must be composed of three layers:
• A preliminary sealed packaging (recipient) that contains the actual material being transported.
• A secondary packaging, strong and sealed, that makes it possible to protect one or more primary recipients surrounded by sufficient absorbent material to absorb all the liquid in the event of a leak.
• An outer packaging used to protect its contents and guarantee the cold chain where necessary.

Each primary consignment must not exceed 1 litre for liquids, or 1 kg for solids. The maximum quantity of category B biological matter transported in a parcel is four litres or four kg. The parcel must be correctly marked, labelled and accompanied by the transport documents.

A pre-qualified insulated shipping packaging is essential for heat sensitive samples. Heat sensitive samples must be transported strictly compliant with the cold chain, to preserve their effectiveness. Depending on their stability, they are transported at between +2 and +8°C (or even +2 and +4°C) or below -18°C.

Laboratories, depositories and CROs use heat insulated packaging. During home care, qualified heat insulated bags are used to transport the product. On the return, the samples (blood, skin, etc.) are transported in UN3373 heat insulated packaging, from the place the sample was taken (hospital or laboratory) to the analysis laboratories.

UN3373-Friendly Systems
Sofrigam has recently developed a line of UN3373 temperature-controlled packaging for the safe transport of clinical trials.

Chief among these, its Clinibox® packaging line guarantees the safe, temperature controlled transport of clinical trials (clinical samples, diagnosis samples or category B biological materials). It both guarantees compliance with applicable regulations covering the transport of hazardous goods (IATA and ADR) and compliance with the cold chain. The cold chain packaging is tested and qualified by Sofrigam’s partner, the Ater Métrologie laboratory – using the ISTA 7E profile for thermal performances, and a minimum height of 1.2 m for the drop impact test.

These UN3373 transport kits are composed of VIAL 650 pouches and a heat insulated box. The VIAL 650 pouch (secondary packaging) is certified 95 kPa by an IATA approved laboratory. It is divided into several separate compartments that contain a sufficient quantity of absorbent material and in which the tubes are placed directly. It thus complies with the tube separation requirement and the requirement for protection from leaks. As for the heat-insulated box (external packaging), it is manufactured using rigid polyurethane panels and cooled using cooling gel packs.

Clinibox® variants accommodate consignments varying from less than five tubes to as many as 25 vials at temperatures below -18°C for up to 72 hours with gel cooling and up to 96 hours, using dry ice.

Sofrigam says it can also produce UN3373-compliant temperature-controlled packaging to individual dimensions, depending on detailed customer requirements.

About Sofrigam
French company, Sofrigam S.A. designs and manufactures cool chain shipping solutions and insulated boxes for the pharmaceutical and biotechnology industries as well as for distribution and logistics companies.

The company was founded in 1979 by an industrial pharmacist and initially developed eutectic painkillers before specialising in the design and manufacture of insulated and refrigerated packaging.

Sofrigam offers solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customised services designed to achieve a secure, cost effective and ecological cold chain logistics.

Sofrigam has become one of Europe’s leading cold chain specialists. The company shares its expertise via seminars, publications and R&D collaborations. It also offers customised products and services designed to achieve cold logistics that are secure, cost-effective and comprehensively meet specific requirements.

Sofrigam is headquartered in Ile-de-Franc with a production site at Arras in Northern France.

For more information about UN3373 raises stakes for biological substance shipping, please contact Sofrigam directly.

Innovative Container Solves Pharma Challenge – Cool Chain Shipping by Air

Press Release – Sofrigam S.A
Innovative Container Solves Pharma Challenge – Cool Chain Shipping by Air

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Innovative Container Solves Pharma Challenge – Cool Chain Shipping by Air
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

NOVEMBER 20, 2013

Innovative Container Solves Pharma Challenge – Cool Chain Shipping by Air

Cedex, France: – French cold chain shipping specialist Sofrigam S.A. says it has managed to overcome one of the most difficult challenges confronting pharmaceutical and biotech companies – the transport of temperature sensitive products and supplies via air cargo.

Sofrigam has purpose-engineered a version of its innovative Frizbox® Pallet Shipper to optimise it for air transport.

The market for cool chain distribution has expanded markedly in recent years with the advent of more specialised biotech and genetic consignments that must obey strict temperature requirements and be shipped quickly and effectively all over the world.

Pharma and biotechnology companies have long wanted to use air cargo for the distribution of highly temperature-sensitive products, to take advantage of its greater speed, security and safety.

Challenges
However, this has been made problematic by a range of particular challenges.

• Compliance with cold chain safety standards set by regulatory bodies such as FDA, AFNOR, ISTA, etc.
• Difficulties and delay in packaging and handling
• Optimisation of volumes shipped by air to limit carbon footprint

Sofrigam cold chain specialist engineer Abbes Kacimi says air cargo presents a particularly challenging environment for heat sensitive consignments.

“The logistics circuit for this means of transport is characterised by specific open or closed, hot or cold, segments such as the runway, transit and passage through customs. This circuit requires a reliable, stand-alone resource without any external energy sources, that can maintain the products within the required temperature range,” M. Kacimi explained.

Purpose-Designed Solution
Now Sofrigam has designed a pre-qualified insulated shipping packaging that is much bigger than that usually used. The Frizbox® Pallet Shipper corresponds to one quarter of an aircraft pallet, and makes it possible to load a European or US standard pallet directly into the container.

With interior volume of up to 2,000 litres, this insulated container can keeps products at controlled temperature between +2°C and +8°C, or +15°C and +25°C. All cooling is provided by gel packs inside the packaging, guaranteeing autonomy and temperature control for as much as ten days.

“This air cargo optimised version of the Frizbox concept provides a flexible, simple and economic solution for cool shipping by aircraft. It makes it possible to ship small and large volumes safely and cost effectively while complying with all international standards,” says M. Kacimi.

About Sofrigam
French company, Sofrigam S.A. designs and manufactures cool chain shipping solutions and insulated boxes for the pharmaceutical and biotechnology industries as well as for distribution and logistics companies.

The company was founded in 1979 by an industrial pharmacist and initially developed eutectic painkillers before specialising in the design and manufacture of insulated and refrigerated packaging.

Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customised services designed to achieve a secure, cost effective and ecological cold chain logistics.

Sofrigam has become one of Europe’s leading cold chain specialists. The company shares its expertise via seminars, publications and R&D collaborations. It also offers customised products and services designed to achieve cold logistics that are secure, cost-effective and comprehensively meet specific requirements.

Sofrigam is headquartered in Ile-de-Franc with a production site at Arras in Northern France.

For more information about cool chain shipping solutions please contact Sofrigam directly.

Cold Chain Packaging

Product – Sofrigam S.A
Cold Chain Packaging

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: Cold Chain Packaging
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Cold Chain Packaging

Securing the cold chain shares the overall logistics trends of minimising cost, hazard and ecological impacts. Sofrigam has built its reputation on the bespoke design and manufacture of polyurethane cold chain packaging that fulfills all three aims. This page describes the bespoke design process.

Advances in bespoke design of insulated packaging
Before design, Sofrigam engineers specialising in the cold chain analyse customer logistics circuit needs. Their studies focus on:
• Risk analysis relative to temperature profiles
• The search for the ideal ratio between working volume and exterior volume
• Shipping preparation procedures that are both simple and rigorous

Cold Chain Packaging

Next comes the packaging design phase. Vincent Bailleul, packaging engineer in Sofrigam’s Research and Development department, describes this part of the process.

“We start by drawing the heat insulated container using 3D software. The manufacturing machines can then use the files. The design office makes a single drawing, with no duplicates or repetitions, and our production colleagues use it to program parameters for the machine. The entire circuit is computerised from initial design to the manufacture of the finished product.”

Polyurethane: an effective and modular insulation
“We design bespoke solutions depending on the pharmaceutical products to be transported, by assembling different formats of polyurethane sheeting. This material is particularly useful for limiting empty spaces in the boxes and adapt to aviation-friendly platforms for long haul export logistics,” notes Laetitia Perche, Sofrigam’s marketing and communications director.

High density polyurethane has low heat conductivity (0.023 W/mK). Thanks to their excellent thermal performance, polyurethane panels optimise the working volume / outer volume ratio of insulated containers. In heat insulated packaging, this makes it possible to limit the need for added chilling and therefore optimise payloads in the transport box.

Cold Chain Packaging

“The flexibility of the manufacturing process without need for tools makes it possible to make products that comply with the specific needs of the customers while guaranteeing quality and assurance of maintaining temperature between, +2°C and +8°C. We can work the raw material, insulating polyurethane foam, into precise shape required.” adds M. Bailleul.

Sofrigam cold chain expertise
Sofrigam specialises in transport of vaccines, ophthalmic products and chemotherapy solutions. Its main fields of expertise are export and long lasting protection over 72 hours (using chilling at 2 – 8°C or freezing temperatures down to -18°C). While EPS (expanded polystyrene) is adequate for domestic transport up to 24/48h, polyurethane is required for international shipping.

Sofrigam’s R&D department is expert in optimising products and researching new, ever more effective, simple to use, ecological and economical concepts. Sofigram develops more than 60 new product concepts every year.

Sofrigam has embedded all three key aspects of economy, safety and ecology in its overall design criteria. The result is that bespoke products offer high standards of performance and adaptability to customer’s own priorities.

For more information or to discuss the the bespoke design of economical, ecological and effective cold chain packaging please contact Sofrigam directly.

Locking System for Insulated Packaging

Video – Sofrigam S.A
Locking System for Insulated Packaging

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Video: Locking System for Insulated Packaging
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Locking System for Insulated Packaging

Locking System for Insulated Packaging – Quick, Secure, Traceable

Product – Sofrigam S.A
Locking System for Insulated Packaging – Quick, Secure, Traceable

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: Locking System for Insulated Packaging – Quick, Secure, Traceable
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Locking System for Insulated Packaging – Quick, Secure, Traceable

Sofrigam’s new concept, a patented locking system for insulated packaging, helps to maintain temperature inside the insulated packaging box with a tighter and more secure seal. At the same time it speeds packaging by up to 50 per cent, compared with traditional closure using straps.

Pharmaceutical labs are faced with a number of problems when shipping heat-sensitive medications and other products in passive packages at controlled temperatures. The overriding concerns are:

• Maintaining temperature-control over sensitive contents
• Ensuring physical security for valuable or hazardous consignments
• Maintaining logistics productivity
• Minimizing preparation/handling times

Now Sofrigam is able to meet all these concerns with a single innovation, the patented Sofigram Locking System for refrigerant packaging.

How it works
The Sofigram Lock is the result of two years of research and development by our engineers; an ingenious system of rotating cam locks and covers incorporated into the doors of the insulated package.

To seal the package, the operator simply inserts Sofigram Locks into the apertures at the edges of the carton lid, rotates each lock 90 degrees to clamp into place and finally presses on the latching covers.

Four locks can be fitted in around half the time it normally takes to pull on two ratcheting shipping straps and secure them tight.

Advantages
Secure, tamper-proof and individually numbered, the locks ensure complete protection for the contents of the carton as well as end-to-end traceability. They also provide a tighter seal than strapping, maintaining more rigorous temperature control.

The Sofigram Locking System meets all the quality requirements and logistical constraints of pharmaceutical laboratories. It provides them with a locking solution optimised for temperature-controlled consignments. This is a solution that simultaneously speeds shipping while increasing security during transport.

For more information or to discuss the locking system for insulated packaging please contact Sofrigam directly.

Isothermal Packaging

Product – Sofrigam S.A
Isothermal Packaging

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: Isothermal Packaging
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Isothermal Packaging

Frizbox 1143 iso

Until recently the main problems associated with cold chain logistics have been related to the transport of +2 and +8°C pharmaceutical products. However with the foreseeable introduction of the temperature range +15 and +25°C into the Best Practices for the Distribution of Medicines guidance, this range is now becoming the new challenge. Quantities of temperature-sensitive pharmaceutical products to be transported between +15 and +25°C are increasing and mainly include ambient products.

Sofrigam are able to offer three isothermal packaging solutions to fulfil this need. The configuration depends on the temperature profile and the thermal inertia of the products.

Insulated box without cold source
This is the simplest and cheapest solution to utilize, maintaining products between +15 and +25°C for moderate temperature profiles or for profiles alternating hot segments above +30°C and cold segments below +15°C.

Sofribox

Insulated box with eutectic gel packs 0°C
By combining frozen and non frozen eutectic gel packs for very hot profiles and non frozen gel packs for cold or moderate profile maintains the product temperature between +15 and +25°C.

Insulated box with positive PCM
This solution uses phase change materials (PCM) with a melting temperature between +18 and +22°C. These PCMs are best suited to keep products between +15 and +25°C for hot and cold temperature profiles using their latent heat in both directions (melting and freezing). However this is a costly solution.

Depending on your logistic requirements and your budget Sofrigam offer three options allowing you to find a solution that best suits individual needs.

For more information or to discuss isothermal packaging please contact Sofrigam directly.

Sofrigam Official Sponsors of The Cold Chain Days

Press Release – Sofrigam S.A
Sofrigam Official Sponsors of The Cold Chain Days

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Sofrigam Official Sponsors of The Cold Chain Days
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

MARCH 26, 2013

Sofrigam Official Sponsors of The Cold Chain Days

Sofrigam, the specialist designer and manufacturer of insulated and refrigerated packaging for the pharmaceutical industry was official sponsor of The Association Française du Froid (AFF) and the Société française des sciences et techniques pharmaceutiques (SFSTP) organised Cold Chain Days event held at the Ecole Normale Supérieure of Lyon in November.

The 3rd edition of the event, hosted official organizations alongside professionals from the pharmaceutical, refrigeration, transport, logistics and packaging worlds and allowed open discussions on the work carried out on the cold chain dynamics as applied to health products and on new outlooks for this field.

Sofrigam’s CEO, member of the AFF/SFSTP scientific community and chairman of the Health Product Sustainable Development and cold chain committee, Gilles Labranque co-presented the morning of the 22nd November dedicated to sustainable development and the carbon footprint of heat-sensitive health products.

Speaking regarding the success of the event, Gilles Labranque commented: “This event was very successful it allowed us to showcase our new insulated packaging solutions for the cold chain transport of your pharmaceutical products.”

About Sofrigam
French company, Sofrigam was founded in 1979 by an industrial pharmacist. The company developed a range of eutectic painkiller doses before specializing in the design and manufacture of insulated and refrigerated packaging. Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customized services designed to achieve a secure, cost effective and ecological cold chain logistic.

For more information or to discuss the Cold Chain Days exhibition please contact us directly.

Sofrigam’s Brand New Innovation Shortlisted by the Grands Prix du Froid

Press Release – Sofrigam S.A
Sofrigam’s Brand New Innovation Shortlisted by the Grands Prix du Froid

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Sofrigam’s Brand New Innovation Shortlisted by the Grands Prix du Froid
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

MARCH 22, 2013

Sofrigam’s Brand New Innovation Shortlisted by the Grands Prix du Froid

Sofrigam, the European leader in refrigerant packaging has participated in the prestigious Grand Prix du Froid 2012. Competing in the ‘Best Packaging Innovation’ and Small Containers’ category, the awards recognise innovation within the refrigeration industry (manufacturers, fitters and users).

Sofrigam submitted innovation which involved 2 years of research by its R&D team was shortlisted from the 33 entries presented to the judging panel. The brand new concept consists of an innovation that closes off refrigerating packaging with a lock, speeding up packaging time and ensuring security in transit. This new closure system ensures packaging remains sealed and solves the many issues associated with cold chain transit, including security, productivity and temperature maintenance of sensitive products. The quick locking systems will optimise package fill while ensuring products are transported in total security.

About Sofrigam
French company, Sofrigam was founded in 1979 by an industrial pharmacist. The company developed a range of eutectic painkiller doses before specializing in the design and manufacture of insulated and refrigerated packaging. Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customized services designed to achieve a secure, cost effective and ecological cold chain logistic.

About Grands Prix du Froid
Held annually, the Grands Prix du Froid rewards the talent businesses and encourages innovation. The networking event unites those most influential in the cold chain transit industry. This year the awards attracted 33 applications, 12 jurors professional 17 nominees, 1050 votes, 10 winners and 200 guests.

After weeks of voting online on the website of Cold Chain Forum six categories were awarded and three special prizes were presented.

For more information or to discuss Sofrigam’s brand new innovation please contact us directly.

Sofrigam Make First Steps into US Market

Press Release – Sofrigam S.A
Sofrigam Make First Steps into US Market

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Sofrigam Make First Steps into US Market
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

OCTOBER 22, 2012

Sofrigam Make First Steps into US Market

Sofrigam, the specialist designer and manufacturer of insulated and refrigerated packaging for the pharmaceutical industry, has shown commitment to expanding into new territories by attending two of the largest trade shows across Europe and USA.

As part of its concerted effort to expand into new territories, Sofrigam was the offical sponsor at the Cold Chain & Temperature Management Global Forum. The 10th annual global event, organised by IQPC was held in Chicago on 26th-27th September. During the show, Sofrigam exhibited its top products; the Pallet Shipper XXL, its range of VIP cooling packs and its new packaging ranges; Clinbox, temperature-controlled containers designed for the transport of clinical trials and the Nomad and cooling bags for the transport health products and patients. In addition, Sofrigam’s US Vice President, Chris Day took to the stage and lead the conference on 26th September with a talk entitled, From Pallet Shipper to Logistics Tool: Total cost Analysis of Bulk Shippers.

In October, the company exhibited at the US organized conference, PDA Pharmaceutical Cold Chain Management & Good Distribution Practice in Berlin. During the two day event, Sofrigam welcomed visitors to its stand and presented its insulated packaging solutions for the transport of pharmaceutical products under temperature controlled conditions.

Both shows have proved a success for Sofrigam and they will look to take part in further events throughout the US. Christopher Day, vice president said “By taking part in these specialist trade shows, we are able to reach new markets and establish new relationships. We are currently amongst the leaders in the European packaging market, have a subsidiary in Canada and an established distribution network in Australia so, we see the US market as the next logical step in building on Sofrigam’s success. Our products were very well received at both events and we look forward to following up the contacts we made.”

About Sofrigam
French company, Sofrigam was founded in 1979 by an industrial pharmacist. The company developed a range of eutectic painkiller doses before specializing in the design and manufacture of insulated and refrigerated packaging. Sofrigam offer solutions for the cold chain consignment problems experienced by the pharmaceutical industry. It offers a range of standard and made-to-measure cooling packaging products as well as customized services designed to achieve a secure, cost effective and ecological cold chain logistic.

About IQPC Cold Chain & Temperature Management Global Forum
The 10th Annual Cold Chain & Temperature Control Global Forum will examine the modern cold chain – including all temperature range products and their regulatory requirements – as well as evolving sectors such as Medical Devices & Diagnostics, Generics, APIs, Clinical and Biologics and cell therapies.

About PDA Pharmaceutical Cold Chain Management & Good Distribution Practice Conference
The 2012 Pharmaceutical Cold Chain & Good Distribution Practice Conference will provide guidance on the handling and distribution of temperature-sensitive pharmaceuticals as it relates to patient safety and product integrity.

Contact:
Christopher Day
Vice-President US
Sofrigam S.A
Mobile: (847) 343-4936
E-mail: chris.day@sofrigam.com
www.sofrigam.com

For more information or to discuss Sofrigam in the US market please contact us directly.

A New Warehouse Storage Building for Sofrigam

Press Release – Sofrigam S.A
A New Warehouse Storage Building for Sofrigam

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: A New Warehouse Storage Building for Sofrigam
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

22 AUGUST 2012

A New Warehouse Storage Building for Sofrigam

Sofrigam have built a new 3,000m² warehouse for the storage of finished products and raw materials. The new building is located at their current site in the Artoiple industrial estate at Monchy-le-Preux in the north of France.

The new building will allow Sofrigam to develop its just-in-time delivery service to manage the ever increasing safety stocks for its customers.

In compliance with Sofrigam’s environmental policies, this warehouse is fitted with a wind turbine which will supply the equivalent of the office electricity consumption for 8 to 9 months, low consumption lighting and a tank for the collection of rainwater for the toilets. Resolutely green, the cladding of this new building was built exclusively using wood, and the building was equipped with high performance insulation, the same that we use in our packing: polyurethane.

About Sofrigam
Sofrigam designs and qualifies industrial insulated and refrigerated packaging solutions enabling the transport of heat sensitive products (chilled or frozen) in non-refrigerated vehicles. We offer our clients a range of standard and made-to-measure cooling packaging products as well as customised services designed to achieve a secure, cost-effective and ecological cold chain logistic which meets your requirements.

For more information or to discuss the new warehouse storage building for Sofrigam please contact us directly.

Sofrigam Partner with ModusLink for Warehousing, Fulfilment and Transportation Services

Press Release – Sofrigam S.A
Sofrigam Partner with ModusLink for Warehousing, Fulfilment and Transportation Services

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Sofrigam Partner with ModusLink for Warehousing, Fulfilment and Transportation Services
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

21 AUGUST 2012

Sofrigam Partner with ModusLink for Warehousing, Fulfilment and Transportation Services

Sofrigam have completed an agreement with ModusLink Global Solutions™ Inc. (MLINK) to provide key warehousing, fulfilment and transportation services for Sofrigam’s world-class pharmaceutical cold chain packaging products.

This new venture means Sofrigam’s insulated boxes will be in a total of 30 warehouses and fulfilment sites in 15 countries. Sofrigam can now locate their refrigerant packaging closer to key customer operation and manage more frequent inventory call offs in line with customer demand. Refrigerant containers and packaging materials are manufactured and tested to ISO quality standards in Sofrigam’s facilities in Europe and North America.

Christopher Day, vice president, North America, Sofrigam said “In our industry, value is added through sophisticated design and manufacturing. Global distribution is a must, but it doesn’t make economic sense for us to do it ourselves. This partnership will give us flexibility to position inventory to best serve our customers throughout the world and will quickly enable the global expansion of our business as the market for temperature-sensitive shipping materials continues to grow.”

“Sofrigam needed a highly reliable supply chain provider to manage complex international distribution and logistics for their pharmaceutical customers,” said Thomas Nightingale, president, sales and marketing, ModusLink. “Our worldwide operations network is unified with a strong systems infrastructure and Lean Sigma-based operations that ensure the consistency and efficiency of our distribution services and is a perfect match for Sofrigam and other clients looking to expand their business globally.”

Through its network of carriers, ModusLink delivers to 140 countries from 30 solution centers worldwide, all connected by a single technology infrastructure.

“In our industry, value is added through sophisticated design and manufacturing. Global distribution is a must, but it doesn’t make economic sense for us to do it ourselves” said Christopher Day.

About Sofrigam
Founded in 1979, Sofrigam is the oldest and largest pharmaceutical cold chain packaging company in Europe. Headquartered outside Paris, France, and manufacturing on multiple continents, Sofrigam provides a full range of custom and pre-qualified temperature controlled packaging solutions to the biopharmaceutical and premium food markets. Known for its technical expertise and new product innovations, Sofrigam’s products range from individual pouches and bags for patients to transport their life-saving medications to full pallet systems used by global biopharmaceutical companies for exporting their products around the world. The new Frizbox® XXL is the only pallet shipper whose payload fits one full US-size pallet of product loaded by forklift, while its exterior footprint fits exactly four to an airline pallet. With its recently completed expansion, Sofrigam’s laboratory, design and manufacturing facility in Monchy-le-Preux, France is the largest facility in the world dedicated solely to temperature controlled packaging.

About ModusLink Global Solutions
ModusLink Global Solutions Inc. designs and executes global supply chain strategies to solve clients’ cost, time-to-market, customer satisfaction and revenue objectives. Our supply chain, aftermarket, e-Business and entitlement management solutions support the end-to-end product lifecycles of the world’s leading companies. ModusLink has more than 25 years of experience executing complex supply chain processes such as sourcing, configuration and fulfilment. We can manage these critical functions seamlessly with a client’s global e-Business initiative or an integrated aftermarket program, including alternative channel recovery for at-risk inventory. Backed by a footprint of more than 30 Solution Centers in 15 countries, ModusLink clients can react quickly to shifting market dynamics impacting value chain performance and revenues.

For more information or to discuss Sofrigam partner with ModusLink for warehousing, fulfilment and transportation services please contact us directly.

Insulin Transportation – Cooler Bags

Press Release – Sofrigam S.A
Insulin Transportation – Cooler Bags

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Insulin Transportation – Cooler Bags
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

02 AUGUST 2012

Insulin Transportation – Cooler Bags

Sofrigam fully understands the importance of the preservation of insulin and therefore provides solutions to protect insulin in transportation. The preservation of insulin is one of the major preoccupations for patients, as it is for the distributors and dispensing chemists.

Insulin Cooler Bags
Sofrigam offers insulin travel bags for safe insulin transportation from laboratories to distributors, wholesalers or chemists. Sofrigam supplies various ranges of heat insulated packaging to accommodate the volume of products to be shipped and the travel time.

Insulin Cooler Pouch – Coolvax
Sofrigam also offers the Coolvax which is a cooler pouch that can be purchased directly from us and is for use by diabetics to preserve their insulin at between +2°C and +8°C on transportation from the chemists to home or for short travel trips. The cooler pouches are available in various sizes and preserve the insulin from 30 minutes to 2 hours. For larger volumes of insulin or for longer travel times, then the Thermotousse or Sofribag packaging should be used. These bags are reusable and just need to be disinfected after each use, no further maintenance is required.

Insulin must be stored and transported with care as it is susceptible to factors such as excessive heat and freezing. As insulin is a heat sensitive product it needs to kept within in a safe and controlled range of temperatures. Therefore there should be no temperature variations in order to guarantee the effectiveness of the treatment. Insulin must not reach the critical +8°C or drop below +2°C, if this occurs the insulin deteriorates it is therefore critical to ensure the insulin is kept at the same temperature throughout transportation.

From the moment the insulin is prepared in the injector pen, it can be kept at room temperature for a short time before use (up to about +20°C). However it must never be subjected to major temperature fluctuations or be exposed to heat. In summer it may be necessary to use heat insulated packaging with a gel pack to maintain the correct temperature.

To avoid freezing, the gel must be used correctly for example, it is better to keep it in the refrigerator before use rather than the freezer.

Sofrigam’s insulin cooler bags have two pouches which are used for gel packs which are quite slim and do not come into direct contact with the product. This keeps the insulin cool when outside temperatures are high, without the risk of freezing.

The incorrect preservation of insulin can make the treatment ineffective. It is strongly recommended not to use an insulin injector pen that has been exposed to heat or been frozen (through incorrect use of a refrigerating gel for example). Insulated or refrigerant packing is essential for preserving all the therapeutic properties of the treatment.

For more information or to discuss insulin transportation cooler bags please contact us directly.

Temperature Sensitive Reusable and Flexible Cool Bags – Sofribag®

Product – Sofrigam S.A
Temperature Sensitive Reusable and Flexible Cool Bags – Sofribag®

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: Temperature Sensitive Reusable and Flexible Cool Bags – Sofribag®
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Temperature Sensitive Reusable and Flexible Cool Bags – Sofribag®

The Sofribag® are temperature sensitive reusable and flexible cool bags. Designed for the transportation of medicinal products in the hospital environment. They are suitable for short-duration transport of products in the biotechnological, pharmaceutical, chemical and agri-food fields.

Using the refrigerated Sofribag in conjunction with cold accumulators, they store heat sensitive products, chilled or frozen, in the required temperature range.

Temperature Sensitive Reusable and Flexible Cool Bags - Sofribag®

Sofribag® Technical Specification:
• Duration: from 1 to 24 hours
• Temperature range: +2/+8°C and -18 °C
• Volume: from 1 to over 35 litres
• Insulation: polyurethane foam
• Exterior in washable nylon or fabric
• Interior in washable PVC
• Zip closure
• External pocket
• Side grip straps
• Cold source: Gel packs using a high performing eutectic gel
• Qualification: bags tested and qualified in accordance with standard NF S 99-700, in ISTA certified metrology laboratory

Cool Bag Advantages:
• Ease of use: simple method of operation and easy handling
• Washable
• Reusable many times
• Ability to secure the closure (depending on model)
• Customization (on request)

For more information or to discuss the temperature sensitive reusable and flexible cool bags – Sofribag® please contact us directly.

All Purpose Icebox – Plasibox®

Product – Sofrigam S.A
All Purpose Icebox – Plasibox®

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: All Purpose Icebox – Plasibox®
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

All Purpose Icebox – Plasibox®

The all purpose icebox Plasibox® is a rigid, robust and reusable isothermal box. Used in conjunction with cold accumulators, the flagship Plasibox® insulated box can be used to transport chilled or frozen products safely. It is also suitable for short duration transportation (maximum 48hrs) of pharmaceutical, biotechnological, chemical and agri-food products.

All Purpose Icebox - Plasibox®

Icebox Advantages:
• Thermal performances: excellent overall coefficient of heat transfer K
• Solidity: resistance to mechanical impacts, the rigid icebox safeguards your transportation
• Reusable and washable: polyester covering washable with alchol, chlorinated water or any other disinfectant
• Ease of use: simple method of operation with side handles making it is easy to handle
• Compatible with all methods of transport, no dry ice
• Standard or specific qualification in accordance with standard NF S 99-700 and according to ISTA
• Option to fit a tamper proof system

Plasibox® Technical Specifications:
• Duration: from 1 to 48 hrs
• Temperature range +2/8°C, +2/25°C and <-5°C
• Volume: from 4 to 45 litres
• Insulation: high density rigid polyurethane panels (λ= 0,023 W/m.k, density 32 kg/m3), with strategic coating
• External overwrapping: rigid plastic case
• Cold source: eutectic briquettes using a high performing eutectic gel
• Qualification: packaging tested and qualified in accordance with standard NF S 99-700, in ISTA certified metrology laboratory

For more information or to discuss the all purpose icebox – Plasibox® please contact us directly.

Leanbox Refrigerated Box

Product – Sofrigam S.A
Leanbox Refrigerated Box

Leanbox Refrigerated Box

Contact Supplier: Sofrigam S.A
Supplier Product: Leanbox Refrigerated Box
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Leanbox Refrigerated Box

Sofrigam have developed the Leanbox refrigerated box a refrigerated box which will enable the user to pick their order rapidly and easily in preparation for its dispatch.

The Leanbox refrigerated box is designed to keep pharmaceutical products cool during the transportation process. The Leanbox refrigerated box can be reused and is effective for most of the year. Products can be kept at a temperature of +2/+8°C when the outside temperature ranges from +15°C to +25°C using the same packaging, the same number of eutectic packs and the same process.
Leanbox Refrigerated Box
With the Leanbox refrigerated box the user can pick their orders within 30 seconds. Work has gone into the design process of the Leanbox in order to make it as simple to use as possible. The Leanbox is superb for carrying small quantities of medicines in accordance with the cold chain.

The Leanbox has a high-quality temperature performance with a minimum amount of cold storage medium (1kg of eutectic gel) irrespective of outside temperatures.
Polyurethane panels are used in the assembly of the Leanbox refrigerated box. The Leanbox contains 2 eutectic packs to be installed easily on the top of the tub and plastic overwrapping.

The Leanbox refrigerated box also has the capacity to incorporate a temperature recorder for analyzing cold chain traceability.

For more information or to discuss the Leanbox refrigerated box please contact us directly.

Insulated and Refrigerated Boxes

Press Release – Sofrigam S.A
Insulated and Refrigerated Boxes

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Insulated and Refrigerated Boxes
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

26 OCTOBER 2011

Insulated and Refrigerated Boxes

The objective of the following article is to show the advantages of utilising a well-defined set of specifications determined by the customer who is looking for an insulated or refrigerated box. Firstly, the article will explain the disadvantages of not having a complete set of specifications. The article will then set out the minimum information required in regards to developing a refrigerated box.

Advantages of Specifications
The lack of certain features can dissuade a customer from making the purchase of a new piece of equipment. When it comes to consumer goods, research is carried out in respect to what is expected of a target product, then a set of specifications are drawn up which set out the necessary features the new product must have. This will enable the product to reach the broadest possible public target.

When developing a insulated or refrigerated box specifically for a customer the situation alters. Before the initiation of design work on the actual product, the customer must first specify what is required. The two main advantages of using a defined set of specifications established by the customer are:

• It shows that the requirements have been described and eluciated internally prior to contacting the supplier. Incorporating different departments such as logistics, quality and purchasing is highly advocated. This will enable the requirements of each department to identified and discussed in the event of non-compatibility.

• It will provide direction to the supplier. Delays and questions will be avoided because the requirements will have been deliberated beforehand.

In the case of insulated and refrigerated boxes, these products are occasionally a new concept to customers. By drawing up a set of specifications the customer can be established a link with the supplier thus initiating a partnership. The supplier can draw on their experience to help set out the requirements of the customer and identify any specific features which are unachievable, since either they are not technically feasible or because certain criteria are not compatible i.e. cost and deadline, compliance with quality.

Subject to the reactivity of each party, the amount of time required could vary. However, it is necessary to agree on the definitive set of specifications and initiate the development of the final product.

A product will not satisfy expectations if the set of specifications is inadequate. Further to this, it could result in a failure to meet the initial deadline and provisional cost if the requirements are altered during the development phase of the product.

Inadequately Defined Specifications
The supplier is best placed in regards to whether the expected specific criteria are attainable. The most frequent causes of problems are:
• Technical incompatibility: the product did not meet expectations due to the desired technical specifications.

• Inconsistency between criteria: the desire to have a multi-functional product which is highly efficient even under tough conditions at the same time, or an innovative product made available in short period of time.

The above cases require an agreement between the supplier and the customer to identify which criteria are non-negotiable. This will put the supplier on the right track in terms of product development and will make sure that they fully comprehend the client’s requirements. Alternative solutions can be found in many cases in regards to cost, deadlines and quality.

In reality, these three concepts are closely related: altering the details for one of the criteria indicates altering direction on the other two as well. Many times when the customers requests for an increase in ‘quality’ they will also request for a reduction in the ‘deadline’ and ‘cost’.
Even though new designs originate from existing products, time for development will still be required so that they can be adapted. Tests are necessary in order to check that the solution is reliable. The tests have monetary costs and will add additional time.

Minimum Specification for Developing a Refrigerated Box
With the purpose of assisting both regular and occasional customers, the following list of minimum information to be supplied in order to produce the best solution from a performance perspective:
• The temperature range for products to be transported
• The number of products to be placed inside the box and the unit dimensions
• The temperature profile(s) to which the box will be exposed and the period of use

Examples for the latter criterion already exist in various guides (ISTA, C3, and so on) or standards (Afnor NF S 99-700). Although validation of the actual box in question is advocated because the examples do not mirror the logistical chain of the customers.

The minimum information is not sufficient to ensure that the optimum solution will be achieved for a given customer. Actually it is possible to develop various types of boxes that meet all three criteria. The most appropriate will be the one that achieves the requirements of the following departments:
• Quality – the requirement for a solution that is efficient under all conditions
• Order preparation – the requirement for a box that is ergonomic and simple for employees to prepare
• Logistics – the requirement for a box which is characterised by an optimum volume and weight
• Purchasing – the requirement for a cost-effective box in order to achieve a given budget

The above list is not exhaustive. When the specifications are not properly clarified, the supplier can often find themselves asking: which criteria have first priority? The decision of the supplier will no longer match the requirements of the customer. Therefore, the risk of presenting a noncompliant solution can result in a misunderstanding between the customer and supplier.

For instance it is a common request for a single set-up refrigerated box that is able to provide efficiency all year round. This provides a solution to the problem of changing box preparation inaccordance with the season. These types of criterion often come from the validation or quality department. This type of option however is more difficult to implement from the perspective of the order preparation or logistics departments. This option requires thorough organisation and involves approximating the set-up casts at an early stage: space required for storing packages, chilling and freezing equipment, forecasting peak times etc. Further to this, supplying larger packages involves additional costs that need to be considered at the beginning of the project.

A single set-up option is more costly from a purchasing perspective because it involves additional inner elements compared to a multi set-up option. The purchasing product is restricted to a budget. Consequently, to meet a given criterion it is possible that less priority is given to another one. Which criterion should be give less/more priority and why? The customer is accountable in regards to prioritising.

At this point the initial request formulated and authorized in the form of specification, can be utilised to re-instate a dialogue between the two parties and confirm that the original goal is being adhered to.

Conclusion
The specifications are particular to each individual customer. The specifications emerge from the preparations of a specific strategy individual to each customer. When a strategy is created in advance alongside the various departments involved (purchasing, logistics, quality etc.), the need of all parties can be prioritised. The specifications are vital and can be employed to aid the supplier in regards to developing the solution that is most appropriate. The supplier can draw from their experience in the field to provide support and assistance in drawing up the specifications if needed. Discussions from the start can be advantageous in terms of forging a partnership and determining the requirements of both sides so as to build up confidence between both sides. To form a suitable set of specifications, discussions both internally and with the supplier are required. Prioritising discussions before the commencement of the project will not only save time but also build a stronger relationship between the supplier and customer. To discuss our insulated and refrigerated boxes or any other refrigerated solution contact us directly.

Refrigerated Vehicles and Refrigerated Packaging

Press Release – Sofrigam S.A
Refrigerated Vehicles and Refrigerated Packaging

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Press Release: Refrigerated Vehicles and Refrigerated Packaging
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

26 OCTOBER 2011

Refrigerated Vehicles and Refrigerated Packaging

Refrigerated vehicles and refrigerated packaging requirements in respect to the logistics and transport of health products under controlled temperature are continually rising. The escalation of requirements is caused by the increasingly stricter regulations and continuous controls of refrigerated vehicles and refrigerated packaging upon cool chain quality. Suppliers of equipment, distributors, service providers and pharmaceutical companies are motivated to constantly improve and to work hard in order to meet the expectations and statutory requirements in addition to safeguarding patient safety within refrigerated vehicles and with actual refrigerated packaging.

Two solutions have been put forward to transport health products, both refrigerated and frozen under controlled temperature – refrigerated vehicles or insulated packaging. The user, presented with above two solutions will have to decide which one is most compatible to transport temperature-sensitive products. The main factors that come into play when determining the correct option are:

• Cost
• Impact on environment
• Temperature profile
• Distribution and logistics circuit
• Volume of products to be sent
• Temperature range of products
• Qualification and validation of the solution

The above parameters will now be examined to determine their importance in the selection of a solution in regards to the requirements of the cool chain for transporting temperature-controlled products.

Distribution & Logistics Circuit of Medicines
Two types of distribution circuit for human medicines can be identified. To start with, the medicines are transported from the manufacturer’s laboratory to a distribution site belonging to the laboratory or a pharmaceutical agent. Within the hospital circuit, the medicines are then distributed to public or private hospitals. They are sent directly or through a trading group or a wholesale distributor. For the official circuit, the medicines are allocated to retail pharmacies through a wholesale distributor or occasionally directly.

Temperature-controlled transportation or refrigerated vehicles can be arranged from the shipper’s site to the consignees’, directly or using hubs, where sorting is carried out by the grouping and grouping packs. In this situation, packs are transported from the shipper’s site the nearest sorting hubs, from where they are arranged by cosignees’ to geographical zones. The packs are then transported to the ungrouping hubs.

If the transportation process involves refrigerated packaging to be transported by air, packs pass through sorting hubs at airports. Although if transportation is done using static refrigerated packaging, the hubs are not refrigerated – they remain at ambient temperatures (as is the case in international shipping and national distribution over long distances). The hubs must be refrigerated if the transportation is carried out under refrigerated conditions. The distribution and logistics circuit enables an initial choice between both solutions. The use of refrigerated vehicles (generally complete or incomplete) can be modified in the following cases:

• From the manufacturer’s laboratory to the distribution site (normally by full truck)
• In the case of group transport (by full are almost full vehicle), loading and unloading zones and hubs must also be refrigerated to circumvent any break in the cool chain.

Insulated refrigerated packaging for very low temperature shipping, refrigerated by eutectic gel packs or by dry ice to preserve an environment below 30°C, are employed in specific cases, including logistics circuits that include an air transport leg (international shipping and national shipping for long distances), or in the situation where hubs and zones of loading and unloading are not refrigerated. In markedly complex cases, both solutions are combined to ensure the consistency of the cool chain.

Volume to be Sent
Once both solutions can safeguard the necessary temperature range of the products for the specified logistics circuit, the volume of products to be shipped will be the pivotal parameter employed to select the shipping method. The volume parameter has the largest influence in terms of the cost of temperature-controlled transportation than any other.

If the quantity of products does not justify the utilisation of a refrigerated vehicle then refrigerated packaging will be vital. The relocation of heat-sensitive pharmaceutical products from the manufacturer’s laboratory to storage or the distribution site is usually made by a refrigerated vehicle since several temperature sensitive products for several final consignees can be grouped together easily.

Temperature Range
The priority of a particular solution can change in accordance with the temperature range of products. Insulated boxes refrigerated by dry ice are employed for very low temperatures (below -30°C). Refrigerated boxes with specific configuration or air-conditioned vehicles are required for products between 15 and 25°C. The accepted tolerances (excursions) outside the temperature range of the transported product can play a pivotal factor when selecting the solution. The manufacturer laboratory stipulates the tolerances subsequent to carrying out stability tests on the product. Accepted tolerances enable the selection of a solution with excursions, for simplicity or for decreased cost. This way, a complex or costly solution without excursions can be averted.

For instance, for temperatures between 2 and 8°C, if the lowest and highest tolerated temperature limits for the product are 1 and 9°C respectively, the user will have to make the decision between refrigerated packaging qualified between 1 and 9°C, with a simple configuration, or alternative refrigerated packaging qualified between 2 and 8°C, with a complicated configuration (weightier, bigger and more costly). The tolerances specified enable the choice of the former option which is easier and less costly.

Temperature Profile
The temperature profile conveys the sections of the logistics circuit in the form of couples (duration, temperature), from the shipper’s site (removal of products) to the consignees site (delivery of products). The temperature profile is subject to the logistics circuit. Open from closed segments can be differentiated as follows:

• For a closed logistics segment, the temperature is controlled or relatively stable, and doesn’t follow the climatic temperature directly. Cold chambers, temperature controlled rooms, storage warehouses, closed vehicles or work are some examples.
• For an open logistics segment, the temperature is not controllable and is not stable since it follows the climatic temperature directly. Open loading, delivery zones and tarmac of an airport are some examples.

In the case of a temperature profile involving open segments that the refrigerated vehicle is unable to reach, refrigerated packaging will be essential due to its autonomy. In specific cases, it can be used in association with air-controlled vehicles.

In the case of a temperature profile that involves both warm and cold segments i.e. below 0°C, the combination of an air-controlled vehicle and refrigerated packaging could be the most effective solution.

Qualification and Validation
The qualification of the methods used to respect the cool chain is essential. This qualification must be done in accordance with current standards. Various guidelines (recommendations, guidelines and standards) have been determined for the qualification of thermal performances of refrigerated packaging for health products:

• NFS 99-700: Isothermal and refrigerating containers for health products – Thermal performance qualification method. This approved French standard is the most complete reference point
• ASTM D3103-07: Standard Test Method for Thermal Insulation Performance of Distribution Packages, the US standard
• ISTA 7D Procedure: Thermal Controlled Transport Packaging for Parcel Delivery System Shipment
• WHO/IVB/05.23: Guidelines on the international packaging and shipping of vaccines

During the period of time for the establishment of a qualification for refrigerated vehicles for health products, transport companies apply for the ‘Agreement on the transport of perishables and special vehicles to be used for this transport’, which is the ATP agreement in relation to food.

The companies in the cool chain field are aware of the significance of establishing a particular standard, allowing the qualification of refrigerated vehicles for health products, and taking into consideration pharmaceutical requirements. The process for refrigerated vehicle transport is tough to manage since the parameters to be substantiated are numerous and complex. The process will require risk analysis because this process identifies critical points and possible failures. Further to this, analysis will be needed to take corrective actions or preventive measures.

Once the performance qualification of the solution is done then the validation of the overall transport process will take place. The destinations that are chosen for validation of the transport process by refrigerated packaging must be relevant. It is essential that the transport by refrigerated vehicles is continuously controlled in real time.

Costs Involved
An important parameter when selecting the best solution is cost. When two solutions meet the required specifications, the solution with the lowest cost will be chosen. The cost of the solution will be related to the global logistics cost for the service provided. The cost will incorporate the price of transport by refrigerated vehicle or the price of refrigerated packaging, in addition to all the costs produced by the preparation and the employment of the solution (sundry expenses, equipment, energy consumption and salaries of the staffs).

The cost of the solution is also subject to the required safety level. The safety margin, must be determined without overestimation, to avert the wasteful requirements which confound the solution and inflate the cost. Good specifications incorporate an optimised solution and decreased cost.

Environmental Impact
Another factor that should to be analysed in relation to the evaluation of the solution is the impact on the environment. The lifecycle analysis for the same provided service (equivalent result) enables the comparison of the impact on the environment for every solution. This analysis incorporates all systems, all the energy and materials necessary for a certain solution throughout its lifecycle, from the extraction of raw materials through to the treatment at the end of life.

Good Use Practice

For every transport process (static or dynamic), to safeguard the efficiency of the temperature-controlled concept, rules of good practice must be utilised. The main rules in relation to each solution are as follows:

For refrigerated vehicle:

• It is important to stabilise the insulated body of the vehicle at the necessary temperature prior to loading
• If the loading and unloading zones of the vehicle are notrefrigerated the refrigerating unit must be turned during loading and unloading
• Do not place products in the cold air flow of the refrigerating
• When employing a multi-temperature vehicle, products must not touch the separation wall of the compartments unit.

For refrigerated packaging:

• Insulated packaging refrigerated by frozen gel packs should not be stored in a cold room, especially during transit and on arrival. Frozen gel packs must be removed before storage
• The exposure time of the insulated packaging in the open segment must be reduced to the minimum possible
• The validated operating instructions for the preparation and loading must be respected
• For refrigerated packaging, which has two different configurations for summer and for winter, one must make sure of weather forecasts before changing the configuration.

Conclusion
Refrigerated packaging and refrigerated vehicles are resources that complement each other. Individual solutions are adapted for specific cases and for specific stages of the distribution process of medicines. The solution employed must be qualified and need precautions and good use practices to safeguard its efficiency. Refrigerated vehicles are employed for the national distribution of health products in the shape of groupage transport or transport batches. For very low temperatures (below -30°C) insulated boxes (packaging) refrigerated by eutectic gel packs or by dry ice are utilised for international shipping and for long distances in national distribution, since the logistics circuit includes an air transport leg and for the distribution of various volumes (not mastered) of products which do not validate the mobilisation of a refrigerated vehicle. Both methods can be associated in particular cases to safeguard the cool chain environment. Insulated boxes (packaging) minus cold source are joined with refrigerated vehicles to avert a break in cool chain in the transfer and delivery zones or to safeguard the products from the cold air flow (below 2°C) from the refrigerating unit. For more information or to discuss our refrigerated vehicles and refrigerated packaging solutions please contact us directly.

The Pallet Shipper XXL

Video – Sofrigam S.A
The Pallet Shipper XXL

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Video: The Pallet Shipper XXL
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

The Pallet Shipper XXL

Sofribox An Insulated Box to Safeguard the Cold Chain

Product – Sofrigam S.A
Sofribox – An Insulated Box to Safeguard the Cold Chain

Sofribox - An Insulated Box to Safeguard the Cold Chain

Contact Supplier: Sofrigam S.A
Supplier Product: Sofribox – An Insulated Box to Safeguard the Cold Chain
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Sofribox – An Insulated Box to Safeguard the Cold Chain

The Sofribox® is a insulated box to safeguard the cold chain process. The Sofribox® is a sturdy and high performance refrigerated box designed for transporting your temperature sensitive products.

Sofribox An insulated box to safeguard the cold chain

Your products remain safe and the cold chain maintained.

The Sofribox® is constructed of high density rigid polyurethane panels (λ = 0.025 W/m.K, density 32 kg/m3) with external cardboard overwrapping. With the inclusion of a cold source, your insulated box can be used to transport chilled or frozen products. It is very resistant to thermal shocks and enables you to cover an extremely extensive geographic zone.

We can fit out your refrigerating box internally to meet your requirements. Its design has deliberately been kept simple in order to limit the danger of theft but we can also customise your refrigerating box.

Duration : 1 to 4 days
Temperature : +2/+8°C (36°F/46°F), +2/+25°C (36°F/77°F), and down to -18°C (0°F)
Capacity : 1L to 500 L and over

The Sofribox® is also available as a VIP version for extreme conditions. With our VIP range, your temperature sensitive products will remain quite safe for 240 hours. The performance levels of our VIP panels will enable you to comply with the rigorous and fundamental demands of your business.

In Sofribox® packaging with VIP panels, your products will keep for up to 10 days even under the highest external temperatures. For more information or to discuss our Sofribox An Insulated Box to Safeguard the Cold Chain range please contact us directly.

VIP Refrigerated Packaging

Product – Sofrigam S.A
VIP Refrigerated Packaging

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: VIP Refrigerated Packaging
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

VIP Refrigerated Packaging

Our VIP Refrigerated Packaging and all VIP containers are calibrated for transporting your temperature sensitive products throughout the world. The cold chain is maintained in extreme conditions and for up to 10 days.

VIP Refrigerated Packaging

The VIP (Vacuum Insulated Panel) panel is the outcome of ten years of research work. Refrigerated packaging equipped with VIP panels will safeguard the cold chain in extreme conditions and for up to 10 days. In fact, VIP heat conductivity is three times better than that of other insulated products and polyurethane has already been recognised for its performance. Its shelf life varies from 7 to 10 days within the target temperature range. This time is 2 to 3 times better than that offered by the best classic insulated materials.

By using VIP, wall thickness can be reduced and, therefore, the box capacity or the coolant mass increased.

A VIP refrigerated container is made of rigid, high density polyurethane panels (λ=0.023W/mK, density 32kg/m3), of very high density VIP panels (λ=0.003W/mK, density 165 Kg/m3) and includes cooler gel packs. The outer casing is made of single or double corrugation cardboard,
Among our product ranges, Frizbox® and Sofribox® boxes can incorporate VIP panels. They ensure that the cold chain is maintained when logistic circuits require a high level of thermal performance. Our VIP range is ideally suited to prolonged transit times, to areas that are difficult to access and in high temperature conditions.

Duration : up to 240 h
Temperature : +2/+8°C (36°F/46°F), -18°(0°F)
Capacity : 1L to 500 L

The Advantages of VIP Packaging:
• VIP heat conductivity (5 MW/m.K) is three times better than that of other insulated products and polyurethane has already been recognised for its performance.
• Shelf life varies from 7 to 10 days within the target temperature range. This time is 2 to 3 times better than that offered by the best classic insulated materials.
• By using VIP, wall thickness can be reduced and, therefore, the box capacity or the coolant mass increased.
To learn more about our VIP Refrigerated Packaging or VIP containers please contact us directly.

The Pallet Shipper Frizbox

Product – Sofrigam S.A
The Pallet Shipper Frizbox

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Product: The Pallet Shipper Frizbox
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

The Pallet Shipper Frizbox

The Pallet Shipper Frizbox is the ideal packaging solution for large quantities and long transit times (up to 120 hours).

The Pallet Shipper Frizbox

The Pallet Shipper Frizbox® allows you to send your products throughout the world, by air, sea or non refrigerated lorry.

Frizbox® refrigerated packaging is sturdy, efficient and ergonomic. Its external and internal dimensions have been fully optimised. It can have a top or front opening.

We can adapt the Frizbox® container to your requirements (internal layout, size, options). Your insulated or refrigerated packaging will be designed to ensure ease of product loading.

Duration : 1 to 5 days
Temperature : +2/+8°C (36°F/46°F), +2/+25°C (36°F/77°F) and down to -45°C (-49°F)
Capacity : 100 L to 3,000 L

The Pallet Shipper Frizbox exists in an XXL size to optimise air freighting. The Pallet Shipper Frizbox® XXL is a box that can transport 1,500l of health products for more than 96 hours at a controlled temperature (2°C-8°C). The dimensions of our standard XXL version match those of a quarter aircraft platform: therefore, this packaging product is ideally suited to air freighting.

The Pallet Shipper Frizbox is also available as a VIP range for a greater temperature resistance. If you are required to transport large quantities of pharmaceutical, biotechnological or food products in extreme conditions: major temperature fluctuations, areas that are not easily accessible, extremely long transit times etc. Our VIP range has been designed with these constraints in mind.

We have designed the Vacuum Insulated Panel (VIP) that can be incorporated into Frizbox® insulated packaging products. Using the same source of cold as another packaging product, this insulation provides greater autonomy than polyurethane. For more information about The Pallet Shipper Frizbox or other services contact us directly.

Cold Chain Storage and Solutions

Video – Sofrigam S.A
Cold Chain Storage and Solutions

Sofrigam SA Logo

Contact Supplier: Sofrigam S.A
Supplier Video: Cold Chain Storage and Solutions
Address: 212 avenue Paul Doumer, 92508 Rueil Malmaison, Cedex, France
Tel: +33 (1) 46 69 85 00
Fax: +33 (1) 47 25 98 44
Website: www.sofrigam.com

Cold Chain Storage and Solutions

“>